Ageless Quest: One Scientist's Search for Genes That Prolong Youth

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ISBN-10:: 0879696524
ISBN-13:: 9780879696528
Pub. Date:: 12/03/2002
Publisher:: Cold Spring Harbor Laboratory Press

ISBN-10:: 0879696524
ISBN-13:: 9780879696528
Pub. Date:: 12/03/2002
Publisher:: Cold Spring Harbor Laboratory Press

Ageless Quest: One Scientist's Search for Genes That Prolong Youth

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Overview

Ageless Quest is a personal, sometimes controversial, account of the pursuit of a genetic 'cure' for aging by an expert in the field. The author is the Novartis Professor of Biology at the Massachusetts Institute of Technology. Aging has always been regarded as a highly complex process with many degenerative changes leading to the cessation of life. But recent research has identified a relatively simple mechanism that governs the pace of aging. Lenny Guarente's Ageless Quest is a scientific detective story for the baby boom generation. It offers an insider's view of an area of potentially astonishing high reward—and equally high risk.

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ISBN-13:	9780879696528
Publisher:	Cold Spring Harbor Laboratory Press
Publication date:	12/03/2002
Edition description:	New Edition
Pages:	168
Product dimensions:	8.34(w) x 5.70(h) x 0.76(d)

Preface
Chapter 1 Mid-life Crisis
Chapter 2 Getting Started in Aging
Chapter 3 First Genetic Insight
Chapter 4 Identification of the AGE Locus.
Chapter 5 The Rise and Fall of rDNA Circles and the Emergence of SIR2
Chapter 6 A Molecular Blueprint for Prolonging Life Span
Chapter 7 SIR2 as a Universal Regulator of Survival
Chapter 8 Nature Promotes Survival in the Face of Scarcity
Chapter 9 Theories of Aging: SIR2 Is More Evolutionary than Revolutionary
Chapter 10 Calorie Restriction and Life Span
Chapter 11 Aging and Cancer in Mammals
Chapter 12 Relevance to Human Aging
Chapter 13 Starting a Biotechnology Company: Drugs for Aging?
Chapter 14 Aging Gracefully in the 21st Century
Snapshots
Bibliography
Glossary
Index

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Editorial Reviews

Science can be like sausage-sure, you like it, but you're better off not knowing how it's made. But with the arrival this year of a number of tell-all science memoirs, readers can't help but take a peek, deriving a certain lurid thrill. Given the potentially explosive subject matter, one would expect Guarente's account of his pursuit of a genetic "cure" for aging to dish up controversy, but it doesn't. Rather, this slim book delivers pure work-a-day science, without any insider dramatics. Guarente, a biologist at MIT whose work on aging has been featured in the Wall Street Journal, the New York Times and the Boston Globe, does gripe now and again about such things as the hardships of the tenure track. But the balance of the book details the author's intellectual adventure, touching along the way on theories of aging and the workings of the biotech industry. At the heart of his story is a gene called SIR2, which has been found to slow aging in yeast in animals. Could it eventually be used on humans? Possibly. Guarente views aging as a disease that someday might be treatable with new drugs, which raises further provocative questions about the ripple effect treatment could have on population, economics and other social factors. But the author, who excels as a diarist but less as a popular-science pitchman, leaves these questions largely untapped. This, admittedly, makes for sedate though quite amiable, utilitarian reading. (Jan.) Copyright 2002 Cahners Business Information.

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