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VEGF and Cancer

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ISBN-10:: 0306479885
ISBN-13:: 9780306479885
Pub. Date:: 05/26/2004
Publisher:: Springer-Verlag New York, LLC

ISBN-10:: 0306479885
ISBN-13:: 9780306479885
Pub. Date:: 05/26/2004
Publisher:: Springer-Verlag New York, LLC

VEGF and Cancer

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$165.00

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Overview

VEGF and Cancer is a comprehensive and up to date review of current knowledge on the role of vascular endothelial growth factor (VEGF) in cancer.

Key Features:

-Discussion of VEGF as potent angiogenic factor and its role in tumor angiogenesis,

-Review of the biology, molecular properties and regulation of VEGF,

-Discussion of the role of VEGF in a range of different tumor types, both solid tumors and haematological cancers,

-Review of the therapeutic potential of different approaches to block VEGF,

-Review of recent evidence that in addition to its role as an endothelial cell mitogen, VEGF may also be an aurine growth factor for tumor cells, regulating survival and invasion.

This book is aimed at scientists new to angiogenesis and VEGF biology and provides new information for established researchers and scientists. It will also be a useful text for clinicians interested in anti-angiogenic therapy for treatment of human cancers.

Product Details
Table of Contents

Product Details

ISBN-13:	9780306479885
Publisher:	Springer-Verlag New York, LLC
Publication date:	05/26/2004
Series:	Medical Intelligence Unit Series
Edition description:	2004. Corr 2nd Printing ed.
Pages:	188
Product dimensions:	6.20(w) x 9.38(h) x 0.69(d)

	Preface	xi
	Abbreviations	xiii
1.	VEGF and Its Receptors	1
	Activities of VEGF	1
	VEGF Isoforms	2
	Regulation of VEGF Gene Expression	2
	The VEGF Receptors	3
	Role of VEGF in Physiological Angiogenesis	5
	Role of VEGF in Pathologic Conditions	6
	Therapeutic Implications and Perspectives	7
2.	Hypoxic Regulation of VEGF	12
	Transcriptional Regulation of VEGF	12
	Post Transcriptional Regulation of VEGF	13
	Abnormalities in the Hypoxic Regulation of VEGF	16
3.	Molecular Mechanisms of VEGF-Induced Angiogenesis	19
	Angiogenesis	19
	The Role of Vascular Endothelial Growth Factor in Angiogenesis	19
	The VEGF Signal Cascade in Angiogenesis	21
4.	Crosstalk between VEGF and Bcl-2 in Tumor Progression and Angiogenesis	26
	Angiogenic Potential of Tumor Cells Overexpressing Bcl-2	26
	Role of Bcl-2 in VEGF-Promoted Survival of Tumor Cells	29
	Role of Bcl-2 in Endothelial Cells	29
	Clinical Relevance of VEGF and Bcl-2 Expression	31
5.	Vascular Endothelial Growth Factor in Breast Cancer	40
	VEGF and Tumor Growth	41
	Serum VEGF and Breast Cancer	42
	VEGF and Clinical Consequences	43
	Future Strategies in Breast Cancer	44
6.	VEGF and Tumor Progression in Human Melanoma	48
	VEGF in Tumor Angiogenesis	48
	Angiogenesis and Human Melanoma	49
	VEGF in Human Melanoma	50
7.	VEGF in Esophageal Cancer	54
	VEGF in Squamous Cell Carcinoma of the Esophagus	54
	VEGF in Barrett's Disease and Adenocarcinoma of the Esophagus	55
	Circulating VEGF Levels in Esophageal Carcinoma	56
	VEGF and MVD during Neoadjuvant Treatment of Esophageal Carcinoma	57
	VEGF-C and Lymphangiogenesis in Esophageal Carcinoma	59
	Anti-VEGF Treatment of Esophageal Carcinoma	60
8.	VEGF in Colorectal Cancer	64
	Colon Cancer	64
	VEGF in Colorectal Cancer Progression	64
	Prognostic Value of VEGF in Colorectal Cancer Patients	66
	The Role of VEGF in Metastasis of Colorectal Cancer	66
	Anti-Angiogenic Therapy by Interference with the VEGF Pathway in Colorectal Cancer	68
9.	Vascular Endothelial Growth Factor in Malignant Disease of the Central Nervous System	72
	VEGF in the Normal Brain	72
	VEGF Is Upregulated in Malignant Disease of the CNS	72
	Angiogenesis in Glioma	74
	Factors Influencing VEGF Production	76
	C6 Glioma Is an Excellent Model for the Study of High Grade Human Glioma with Regard to VEGF	76
	VEGF Is Responsible for the Virulent Nature of High Grade Gliomas	77
	Interrupting VEGF-Receptor Signaling Inhibits Glioma Growth in Preclinical Models	77
	Current Therapy of Glioma: VEGF Contributes to Treatment Failure	78
10.	VEGF in Hematopoietic Malignancy	83
	The VEGF/VEGF Receptor Pathway	84
	Hematopoietic and Endothelial Cells Share a Common Hematopoietic/Endothelial Progenitor Cell	84
	VEGF Bone Marrow Interactions in Hematological Malignancy	85
	VEGF and Angiogenesis in Acute Leukemia and Myelodysplasia	88
	VEGF and Angiogenesis in Myeloproliferative Disorders	90
	VEGF and Angiogenesis in B-Cell Chronic Lymphocytic Leukemia	92
	VEGF and Angiogenesis in Lymphomas	93
	VEGF and Angiogenesis in Myeloma	94
	VEGF Signalling Pathways As a Therapeutic Target in Hematological Malignancies	95
11.	Targeting VEGF in Pancreatic Cancer	107
	Cancer Metastasis	107
	Tumor Angiogenesis	107
	Regulation of Angiogenesis by the Microenvironment	109
	VEGF/VPF: A Pro-Angiogenic Molecule	109
	Regulation of VEGF/VPF Expression in Tumors	110
	Development of a Human Pancreatic Adenocarcinoma Model	110
	Anti-VEGF Therapy in Pancreatic Cancer	111
	Anti-Angiogenic Therapy: Clinical Implications	112
12.	Effects of Fibrinogen and Associated Peptide Fragments on the Activation of Human Endothelial Cells by VEGF in Vitro	117
	Fibrinogen and Fibrin Formation	118
	Fibrinolysis	118
	Effects of Fibrinogen on Endothelial Cell Activation	118
	Fibrin, VEGF and Angiogenic Mechanisms	124
	Stimulation of VEGF Induced Angiogenesis by Fibrin E-Fragment	126
	Fibrinogen E-Fragment Inhibits VEGF Activation of Endothelial Cells	129
	The Effects of Other Fibrinogen/Fibrin Related Fragment on VEGF-Activation of Endothelial Cells	130
13.	Vascular Endothelial Growth Factor (VEGF) and Its Role in Non-Endothelial Cells: Autocrine Signalling by VEGF	133
	VEGF in the Cardiovascular System	133
	VEGF and the Central Nervous System (CNS)	134
	VEGF and Its Role in Bone	135
	VEGF in Hematopoietic Cells and Hematological Malignancies	135
	VEGF Signalling in Hematopoietic Cells	136
	Evidence for VEGF Autocrine Signalling in Solid Tumors	136
	Autocrine VEGF Signalling in Breast Cancer	137
	VEGF Stimulates Breast Cancer Invasion	137
	VEGF Signalling in Tumor Cells	138
	Anti-Angiogenic Therapy	139
14.	Vascular Endothelial Growth Factor C and Vascular Endothelial Growth Factor D: Biology, Functions and Role in Cancer	145
	Molecular Biology of VEGF-C and VEGF-D	145
	VEGF-C and VEGF-D Signalling and Function	149
	VEGF-C and VEGF-D in Human Malignancy	152
	Potential Therapeutic Roles	156
	Index	163

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