Table of Contents

Introduction - Stephen Neidle Foreword - Hilary Calvert Part I. Basic Principles and methodology Modern cancer drug discovery: integrating targets, technologies and treatments — Paul Workman andIan Collins Pharmacogenomics and personalised medicines in cancer treatment — Wei-Peng Yong, Ross Soo andFederico Innocenti Structural biology and anticancer drug design — Puja Pathuri, David Norton, Henriette Willems,Dominic Tisi and Harren Jhoti Part II. Drugs in the laboratory and clinic Temozolomide: from cytotoxic to molecularly-targeted agent — Malcolm Stevens Temozolomide: patents and the perils of invention — Malcolm Stevens A new generation of cell-targeted drugs for cancer treatment — Paola B. Arimondo, Nicolas Guilbaudand Christian Bailly Inhibition of DNA repair as a therapeutic target — Stephany Veuger and Nicola J CurtinInhibitors of tumour angiogenesis — Adrian L. Harris and Daniele G Generali The Renaissance of CYP17 Inhibitors for the Treatment of Prostate Cancer — Qingzhong Hu and RolfW. Hartmann Apoptosis in Cancer: Mechanisms, Deregulation and Therapeutic Targeting — Zahid H Siddik Targeting the MDM2-p53 protein-protein interaction: design, discovery and development of novelanticancer agents — Ian R Hardcastle Targeting altered metabolism – emerging cancer therapeutic strategy — Minsuh Seo, Robert BlakeCrochet and Yong-Hwan Lee Inhibitors of the Phosphatidylinositol 3-kinase (PI3K) Pathway — William A Denny and Gordon W.Rewcastle Antibody-drug conjugates delivering DNA cytotoxics — John A Hartley Inhibition of telomerase: promise, progress and potential pitfalls — Christopher G. Tomlinson, Scott B.Cohen and Tracy M. Bryan Targeting B-RAF: the discovery and development of B-RAF inhibitors — Phillip A Harris Part III. The reality of cancer drugs in the clinic Failure Modes in Anticancer Drug Discovery and Development — Richard A. Walgren andChristopher. A. Slapak Anticancer drug registration and regulation: current challenges and possible solutions — DavidTaylor, Erling Donnelly and Silvia Chioato