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Diversity and Functions of GABA Receptors: A Tribute to Hanns Möhler, Part A

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ISBN-10:: 012802660X
ISBN-13:: 9780128026601
Pub. Date:: 01/12/2015
Publisher:: Elsevier Science

ISBN-10:: 012802660X
ISBN-13:: 9780128026601
Pub. Date:: 01/12/2015
Publisher:: Elsevier Science

Diversity and Functions of GABA Receptors: A Tribute to Hanns Möhler, Part A

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Overview

This new volume of Advances in Pharmacology presents the diversity and functions of GABA Receptors. The volume looks at research performed in the past 20 years which has revealed specific physiological and pharmacological functions of individual GABA_A receptor subtypes, providing novel opportunities for drug development.

Product Details

ISBN-13:	9780128026601
Publisher:	Elsevier Science
Publication date:	01/12/2015
Series:	Advances in Pharmacology , #72
Pages:	282
Product dimensions:	6.10(w) x 9.00(h) x 0.70(d)

About the Author

Dr. Rudolph is Director of the Laboratory of Genetic Neuropharmacoloy at McLean Hospital and Professor of Psychiatry at Harvard Medical School. He studied medicine and completed a research thesis on G proteins at the Freie Universitat Berlin, Germany. After postdoctoral training at Baylor College of Medicine in Houston, Texas, where he developed a mouse model of inflammatory bowel disease and colon cancer, he moved to the Institute of Pharmacology and Toxicology of the University of Zurich to work on GABAA receptors. There, he developed different lines of knock-in mice in which diazepam-sensitive GABAA receptor subtypes were rendered insensitive to diazepam by a histidine to arginine point mutation. Studying these mice enables researchers to uncover unique functional roles of GABAA receptor subtypes. In 2005, he joined McLean Hospital in Belmont, MA, and Harvard Medical School, where his research group is elucidating the functions of GABAA receptor subtypes in defined neuronal populations.

1. The Legacy of the Benzodiazepine Receptor: From Flumazenil to Enhancing Cognition in Down Syndrome and Social Interaction in Autism
Hanns Möhler
2. Behavioral Functions of GABA_A Receptor Subtypes – the Zurich Experience
Florence Crestani and Uwe Rudolph
3. Allosteric Modulation of GABA_A Receptors via Multiple Drug Binding Sites
Werner Sieghart
4. Regulation of GABA_ARs by Phosphorylation
Yasuko Nakamura, Laura M. Darnieder, Tarek Z. Deeb and Stephen J. Moss
5. Endozepines
Zoya Farzampour, Richard J. Reimer and John Huguenard
6. Inhibitory Neurosteroids and the GABA_A Receptor
Sandra Seljeset, Duncan Laverty and Trevor G Smart
7. Interactions of Flavonoids with Ionotropic GABA_AReceptors
Jane R Hanrahan, Mary Chebib and Graham A R Johnston
8. GABA_A Receptor Partial Agonists and Antagonists: Structure, Binding Mode, and Pharmacology
Jacob Krall, Thomas Balle, Niels Krogsgaard-Larsen, Troels E. Sørensen, Povl Krogsgaard-Larsen, Uffe Kristiansen and Bente Frølund
9. Closing the Gap between the Molecular and Systemic Actions of Anesthetic Agents
Bernd Antkowiak

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This new volume of Advances in Pharmacology will highlight the role of GABA_A receptor diversity

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Diversity and Functions of GABA Receptors: A Tribute to Hanns Möhler, Part A

Diversity and Functions of GABA Receptors: A Tribute to Hanns Möhler, Part A

Hardcover

Overview

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About the Author

Table of Contents

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Overview

Product Details

About the Author

Table of Contents

What People are Saying About This

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Customer Reviews