Table of Contents

1. Introduction Part I: Scientific Foundations 2. Pathophysiology of Seizures and Epilepsy 3. Drug Resistance in Epilepsy and Status Epilepticus 4. Genetics of Human Epilepsy—Epilepsy as a Channelopathy Part II: Antiepileptic Drugs 5. Ontogeny of Molecular Targets of Antiepileptic Drugs: Impact on Drug Choice 6. Epilepsy and Disease Modification: Animal Models for Novel Drug Discovery 7. Nonsynaptic Mechanisms in Seizures and Epileptogenesis: Targets for Clinical Management? 8. A Mechanistic Approach to Antiepileptic Drug Interactions 9. Toxicology of Idiosyncratic Organ Toxicities of AEDs Part III: Epilepsy Surgery 10. Advances in Structural and Functional Neuroimaging: How Are These Guiding Epilepsy Surgery? 11. Magnetoencephalography in Clinical Epilepsy 12. Nonsurgical Ablation of Epileptic Tissue Part IV: Alternative Therapies 13. Special Treatments in Epilepsy 14. The Ketogenic Diet: Scientific Principles Underlying Its Use 15. Vagus Nerve Stimulation 16. Immunomodulation of Epilepsy 17 Neurosteroids: Endogenous Modulators of Seizure Susceptibility Part V: Other Modulators of the Epileptic State 18. Impact of Neuroendocrine Factors on Seizure Genesis and Treatment 19. Chronobiology and Sleep: Implications for Seizure Propensity 20. Psychopathology in Epilepsy: A Window to Brain Behavior Relationships Part VI: The Future of Epilepsy Therapy 21. Novel Mechanisms of Drug Delivery 22. Deep Brain Stimulation: Why Should This Work? 23. Intraoperative Optical Imaging of Epileptiform and Functional Activity 24. Early Seizure Detection: Theoretical and Applied 25. Arresting Epileptogenesis: The Current Challenge