Table of Contents

Recent Advances in the Synthesis of Morphine and Related Alkaloids Noritaka Chida 1

Opioids in Preclinical and Clinical Trials Hiroshi Nagase Hideaki Fujii 29

Synthesis of 14-Alkoxymorphinan Derivatives and Their Pharmacological Actions Helmut Schmidharnmer Mariana Spetea 63

14-Amino-4,5-Epoxymorphinan Derivatives and Their Pharmacological Actions John W. Lewis Stephen M. Husbands 93

Nonpeptidic Delta (δ) Opioid Agonists and Antagonists of the Diarylmethylpiperazine Class: What Have We Learned? Silvia N. Calderon 121

Synthesis of Neoclerodane Diterpenes and Their Pharmacological Effects Kimberly M. Lovell Katherine M. Prevatt-Smith Anthony Lozama Thomas E. Prisinzano 141

Synthesis of Novel Basic Skeletons Derived from Naltrexone Hiroshi Nagase Hideaki Fujii 187

Twin and Triplet Drugs in Opioid Research Hideaki Fujii 239

3D-Pharmacophore Identification for K-Opioid Agonists Using Ligand-Based Drug-Design Techniques Noriyuki Yamaotsu Shuichi Hirono 277

Index 309