Where Medicine Went Wrong: Rediscovering The Path To Complexity
Where Medicine Went Wrong explores how the idea of an average value has been misapplied to medical phenomena, distorted understanding and lead to flawed medical decisions. Through new insights into the science of complexity, traditional physiology is replaced with fractal physiology, in which variability is more indicative of health than is an average. The capricious nature of physiological systems is made conceptually manageable by smoothing over fluctuations and thinking in terms of averages. But these variations in such aspects as heart rate, breathing and walking are much more susceptible to the early influence of disease than are averages.It may be useful to quote from the late Stephen Jay Gould's book Full House on the errant nature of averages: “… our culture encodes a strong bias either to neglect or ignore variation. We tend to focus instead on measures of central tendency, and as a result we make some terrible mistakes, often with considerable practical import.” Dr West has quantified this observation and make it useful for the diagnosis of disease.
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Where Medicine Went Wrong: Rediscovering The Path To Complexity
Where Medicine Went Wrong explores how the idea of an average value has been misapplied to medical phenomena, distorted understanding and lead to flawed medical decisions. Through new insights into the science of complexity, traditional physiology is replaced with fractal physiology, in which variability is more indicative of health than is an average. The capricious nature of physiological systems is made conceptually manageable by smoothing over fluctuations and thinking in terms of averages. But these variations in such aspects as heart rate, breathing and walking are much more susceptible to the early influence of disease than are averages.It may be useful to quote from the late Stephen Jay Gould's book Full House on the errant nature of averages: “… our culture encodes a strong bias either to neglect or ignore variation. We tend to focus instead on measures of central tendency, and as a result we make some terrible mistakes, often with considerable practical import.” Dr West has quantified this observation and make it useful for the diagnosis of disease.
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Where Medicine Went Wrong: Rediscovering The Path To Complexity

Where Medicine Went Wrong: Rediscovering The Path To Complexity

by Bruce J West
Where Medicine Went Wrong: Rediscovering The Path To Complexity

Where Medicine Went Wrong: Rediscovering The Path To Complexity

by Bruce J West

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Overview

Where Medicine Went Wrong explores how the idea of an average value has been misapplied to medical phenomena, distorted understanding and lead to flawed medical decisions. Through new insights into the science of complexity, traditional physiology is replaced with fractal physiology, in which variability is more indicative of health than is an average. The capricious nature of physiological systems is made conceptually manageable by smoothing over fluctuations and thinking in terms of averages. But these variations in such aspects as heart rate, breathing and walking are much more susceptible to the early influence of disease than are averages.It may be useful to quote from the late Stephen Jay Gould's book Full House on the errant nature of averages: “… our culture encodes a strong bias either to neglect or ignore variation. We tend to focus instead on measures of central tendency, and as a result we make some terrible mistakes, often with considerable practical import.” Dr West has quantified this observation and make it useful for the diagnosis of disease.

Product Details

ISBN-13: 9789812568830
Publisher: World Scientific Publishing Company, Incorporated
Publication date: 10/09/2006
Series: Studies Of Nonlinear Phenomena In Life Science , #11
Pages: 352
Product dimensions: 6.00(w) x 8.90(h) x 0.70(d)

Table of Contents


Prologue     ix
Acknowledgments     xiii
Chance and Variation     1
The myth of equality     3
Slaughter's Cafe     10
What are the odds?     14
Odds against smallpox     22
Information and chance     33
The Expectation of Health     37
Control and cybernetics     40
Temperature regulation     46
Respiration regulation     50
Cardiac regulation     57
Averages are not sufficient     65
Even Uncertainty has Laws     69
Randomness and measurement     72
Chaos and determinism     87
Wisdom is not static     94
A new tradition     111
The Uncertainty of Health     119
The different kinds of scientists     124
The Emperor in exile     130
What is wrong with the law of errors     138
The inverse power-law distribution     144
How the physical and life sciences are different     156
Only the few matter     168
Fractal Physiology     173
Scaling in physiological data     176
Allometric relationships     182
Fractal heartbeats     191
Intermittent chaos and colored noise     198
Fractal breathing     204
Fractal gait     216
Fractal temperature     223
Fractal gut     228
Fractal neurons     231
Internetwork interactions     238
Complexity     241
Random networks     244
Scale-free networks     255
Controlling complexity     259
Allometric control     265
Disease as loss of control     273
Disease as Loss of Complexity     283
Pathological periodicities     285
Heart failure and fractal loss     289
Breakdown of gait     302
Summing up     310
Epilogue     315
References     317
Index     327
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