Biology of Humans: Concepts, Applications, and Issues / Edition 4 available in Paperback
Biology of Humans: Concepts, Applications, and Issues / Edition 4
- ISBN-10:
- 0321707028
- ISBN-13:
- 9780321707024
- Pub. Date:
- 01/20/2011
- Publisher:
- Benjamin Cummings
- ISBN-10:
- 0321707028
- ISBN-13:
- 9780321707024
- Pub. Date:
- 01/20/2011
- Publisher:
- Benjamin Cummings
Biology of Humans: Concepts, Applications, and Issues / Edition 4
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Overview
Product Details
ISBN-13: | 9780321707024 |
---|---|
Publisher: | Benjamin Cummings |
Publication date: | 01/20/2011 |
Pages: | 624 |
Product dimensions: | 8.90(w) x 10.70(h) x 0.80(d) |
Lexile: | 1210L (what's this?) |
About the Author
Judith Goodenough
Judith received her B.S. in biology from Wagner College (Staten Island, NY) and her doctorate in biology from New York University. She has more than 35 years of teaching experience at the University of Massachusetts, Amherst, until recently specializing in introductory level courses. In 2009, she was selected as a College of Natural Sciences Fellow for Blended Learning and developed a hybrid course in introductory physiology. The insights into student concerns and problems—gained from more than 30 years of teaching Human Biology and 20 years of team-teaching the Biology of Social Issues—have helped shape this book. In 1986, Judith was honored with a Distinguished Teaching Award from UMass. In addition to teaching, she has written articles in peer-reviewed journals, contributed chapters to several introductory biology texts, and written numerous laboratory manuals. With the author team of McGuire and Jakob, she wrote Perspectives on Animal Behavior, Third Edition.
Betty McGuire
Betty received her B.S. in biology from Pennsylvania State University, where she also played varsity basketball. She went on to receive an M.S. and Ph.D. in zoology from the University of Massachusetts, Amherst, and then spent 2 happy years as a postdoctoral researcher at the University of Illinois, Champaign-Urbana. Her field and laboratory research emphasize the social behavior and reproduction of small mammals. She has published more than 50 research papers, coauthored the text Perspectives on Animal Behavior as well as several introductory biology study guides and instructor manuals, and served as an associate editor for Mammalian Species, a publication of the American Society of Mammalogists. Betty taught Human Biology, Introductory Biology, Vertebrate Biology, and Animal Behavior at Smith College. She now teaches Mammalogy and Vertebrates: Structure, Function, and Evolution at Cornell University.
Table of Contents
Special-Interest Essays xliii
The Organization of the Body
Humans in the World of Biology 1
All Living Things Share Basic Characteristics 2
Living Organisms are Classified by Evolutionary Relationships 4
Life has many Levels of Organization 5
The Scientific Method Gathers Information for Drawing Logical Conclusions 6
Inductive and deductive reasoning help solve problems 9
Clinical trials follow strict guidelines 10
Epidemiological studies look for patterns in populations 10
Critical Thinking Helps Us Make Informed Decisions 11
Environmental Issue: Medicinal Plants and the Shrinking Rain Forest 7
Social Issue: Scientific Misconduct 11
Chemistry Comes to Life 14
Basic Chemistry Helps Us Understand Human Biology 15
Atoms contain protons, neutrons, and electrons 15
Elements combine to form compounds 17
The atoms or ions of a compound are held together by chemical bonds 17
Water is essential to life 20
Carbohydrates, Lipids, Proteins, and Nucleic Acids Are the Major Molecules of Life 23
Carbohydrates supply energy to cells 25
Lipids store energy and form cellmembranes 26
Proteins provide structure and speed up chemical reactions 28
The nucleic acids are DNA and RNA 31
ATP is a nucleotide that releases energy 32
Social Issue: The Ethics of Radiation Research on Humans 18
Environmental Issue: What Is Happening to the Rain? 24
The Cell 37
Our Cells Are Highly Structured 38
Eukaryotic cells are structurally more complex than prokaryotic cells 38
Cells are very small 39
The plasma membrane has diverse functions 39
Organelles are specialized compartments within cells 45
The cytoskeleton provides support and movement 50
Our Cells Use Cellular Respiration and Fermentation to Generate ATP 53
Cellular respiration requires oxygen 54
Fermentation does not require oxygen 59
Environmental Issue: Asbestos: The Deadly Miracle Material 50
Body Organization and Homeotasis 62
The Organization of the Human Body Increases in Complexity from Cells to Organ Systems 63
Groups of similar cells form tissues 63
Many tissues have specialized junctions between the cells 68
Tissues combine to form organs that in turn form organ systems 68
Most organs are housed in body cavities that are lined with membranes 68
The Skin Is an Organ System 71
Skin protects, regulates body temperature, and excretes 71
The skin has two layers 71
Skin color is determined by pigment and blood flow 73
Hair, nails, and glands are skin derivatives 74
Homeostasis Is a State of Relative Internal Constancy 76
Homeostasis is maintained by negative feedback mechanisms 76
The hypothalamus regulates body temperature 76
Health Issue: Fun in the Sun? Sunlight and Skin Cancer 75
Health Issue: Acne: The Misery, the Myths, and the Medications 79
Control and Coordination of the Body
The Skeletal System 82
Bones Function in Support, Movement, Protection, Storage, and Blood Cell Production 83
Bones Have a Hard Outer Layer of Compact Bone Surrounding Spongy Bone 83
Bone Is Living Tissue 84
Most of the skeleton begins as a cartilage model 84
Hormones regulate bone growth 85
Bone Fractures Are Healed by Fibroblasts and Osteoblasts 85
Bones are Continuously Remodeled 86
We Divide the Human Skeleton into Two Parts 86
The axial skeleton protects our internal organs 86
The appendicular skeleton makes locomotion possible 90
Joints Are Junctures between Bones 92
Synovial joints permit flexibility 92
Health Issue: Osteoporosis: Fragility and Aging 89
The Muscular System 97
The Muscular System Moves Our Body Parts and Maintains Our Posture 98
Most Skeletal Muscles Work in Pairs 98
Sarcomeres Are the Contractile Units of Muscles 100
Skeletal muscle contracts when actin filaments slide across myosin filaments 100
Calcium ions and regulatory proteins control contraction 102
Nerves stimulate muscle contraction 102
Muscular dystrophy causes progressive muscle deterioration 102
The Strength of Muscle Contraction Depends on the Number of Motor Units Stimulated 102
The Strength of Contraction Increases If a Muscle Is Stimulated before It Has Relaxed 104
ATP for Muscle Contraction Comes from Many Sources 104
Slow-Twitch and Fast-Twitch Muscle Cells Differ in Contraction Speed and Duration 105
Aerobic Exercise Increases Endurance; Resistance Exercise Builds Muscle 106
Social Issue: Building Muscle Fair and Square? Anabolic Steroid Abuse 107
Neurons: The Matter of the Mind 110
Neurons and Neuroglial Cells Are the Cells of the Nervous System 111
Neuroglial cells support, protect, insulate, and nurture neurons 111
Neurons can be sensory, motor, or associative 111
Neurons Have Dendrites, a Cell Body, and an Axon 112
Axons and dendrites are bundled together to form nerves 112
The myelin sheath increases the rate of conduction and helps in repair 113
The Nerve Impulse Is an Electrochemical Signal 114
Ions move passively through ion channels 114
The sodium-potassium pump uses ATP to transport sodium ions out and potassium ions in 114
The inside of a resting neuron has a negative charge relative to the outside 114
An action potential is a reversal and restoration of the charge difference across the membrane 114
The sodium-potassium pump restores the original distribution of ions 115
Action potentials are all-or-nothing events 115
A neuron cannot fire during the refractory period 117
Synaptic Transmission Is Communication between Neurons 117
Synaptic transmission involves the release of neurotransmitter and the opening of ion channels 117
Neurons "sum up" input from excitatory and inhibitory synapses 118
The neurotransmitter is quickly removed from the synapse 118
Different neurotransmitters play different roles 119
Environmental Issue: Environmental Toxins and the Nervous System 120
The Nervous System 124
The Nervous System Consists of the Central and Peripheral Nervous Systems 125
Bone, Membranes, and Cerebrospinal Fluid Protect the Central Nervous System 126
The Brain Is the Central Command Center 127
The cerebrum is the conscious part of the brain 128
The thalamus allows messages to pass to the cerebral cortex 130
The hypothalamus is essential to homeostasis 130
The cerebellum is an area of sensory-motor coordination 131
The brain stem controls many of life's basic processes and connects the brain and spinal cord 131
The limbic system is involved in emotions and memory 132
The reticular activating system filters sensory input 132
The Spinal Cord Transmits Messages to and from the Brain and Is a Reflex Center 133
The Peripheral Nervous System Consists of the Somatic and Autonomic Nervous Systems 134
The somatic nervous system controls conscious functions 134
The autonomic nervous system controls internal organs 134
Disorders of the Nervous System Vary in Health Significance 135
Headaches have several possible causes 135
Strokes occur when the brain is deprived of blood 138
Coma is a lack of response to all sensory input 138
Spinal cord injury results in impaired function below the site of injury 138
Health Issue: Meningitis: Bacterial-Type and West Nile Virus 126
Health Issue: To Sleep, Perchance to Dream 137
Special Topic: Drugs and the Mind 142
Psychoactive Drugs Alter Communication between Neurons 143
Drug Dependence Causes Continued Drug Use 143
Alcohol Depresses the Central Nervous System 144
The rate of alcohol absorption depends on its concentration 144
Alcohol is distributed to all body tissues 144
The rate of elimination of alcohol from the body cannot be increased 145
Alcohol has many health-related effects 146
Marijuana's Psychoactive Ingredient Is THC 147
Marijuana binds to THC receptors in the brain 148
Long-term marijuana use has many effects on the body 148
Legalization of medical marijuana is controversial 148
Stimulants Excite the Central Nervous System 149
Cocaine augments the neurotransmitters dopamine and norepinephrine 149
Amphetamines augment the neurotransmitters dopamine and norepinephrine 150
Hallucinogenic Drugs Alter Sensory Perception 150
Sedatives Depress the Central Nervous System 151
Opiates Reduce Pain 151
Sensory Systems 152
Sensory Receptors Generate Electrochemical Messages in Response to Stimuli 153
Receptors Are Classified by the Type of Stimulus to Which They Respond 153
Receptors for the General Senses Are Distributed throughout the Body 154
Mechanoreceptors detect touch and pressure 154
Cold and heat receptors detect temperature change 154
Muscle spindles and Golgi tendon organs detect body and limb position 154
Pain is caused by any sufficiently strong stimulus 155
Vision Depends on the Eye 156
The wall of the eyeball has three layers 156
The eye has two fluid-filled chambers 156
Sharp vision requires the image to be focused on the retina 157
Light changes the shape of pigment molecules, which generate neural messages 159
Vision in dim light depends on rods 160
Color vision depends on cones 161
Hearing Depends on the Ear 162
The ear collects and amplifies sound waves and converts them to neural messages 163
Variations in the movements of the basilar membrane determine loudness and pitch 165
Hearing loss can be conductive or sensorineural 165
Ear infections can occur in the ear canal or in the middle ear 168
Balance Depends on the Vestibular Apparatus of the Inner Ear 168
Smell and Taste Are the Chemical Senses 170
Health Issue: Correcting Vision Problems 160
Environmental Issue: Noise Pollution 167
The Endocrine System 174
The Endocrine System Communicates Using Chemical Messages 175
Hormones are the messengers of the endocrine system 175
Feedback mechanisms regulate the secretion of hormones 176
Hormones Influence Growth, Development, Metabolism, and Behavior 178
Pituitary hormones often prompt other glands to release hormones 178
Thyroid hormones regulate metabolism and decrease blood calcium 182
Parathyroid hormones increase blood calcium 185
The adrenal glands secrete stress hormones 185
Hormones of the pancreas regulate blood glucose 188
Hormones of the thymus gland promote maturation of white blood cells 192
The pineal gland secretes melatonin 192
Other Chemical Messengers Act Locally 193
Health Issue: Is It Hot in Here, or Is It Me? Hormone Replacement Therapy and Menopause 188
Health Issue: Hormones and Our Response to Stress 191
Health Issue: Melatonin: Miracle Supplement or Potent Drug Misused by Millions? 193
Maintenance of the Body
Blood 197
Blood Functions in Transportation, Protection, and Regulation 198
Blood Consists of Plasma and Formed Elements 198
Plasma is the liquid portion of blood 198
Stem cells give rise to the formed elements 199
Platelets are cell fragments essential to blood clotting 199
White blood cells help defend the body against disease 199
Red blood cells transport oxygen 201
The effects of blood cell disorders depend on the type of blood cell affected 203
Blood Types Are Determined by Antigens on the Surface of Red Blood Cells 205
Blood Clotting Occurs in a Regulated Sequence of Events 208
Environmental Issue: Lead Poisoning 204
The Circulatory System 211
The Cardiovascular System Consists of the Blood Vessels and the Heart 212
The Blood Vessels Conduct Blood in Continuous Loops 212
Arteries carry blood away from the heart 212
Capillaries are sites of exchange with body cells 215
Veins return blood to the heart 216
The Heart Is a Muscular Pump 218
Blood flows through the heart in two circuits 218
Coronary circulation serves the heart muscle 220
The cardiac cycle is the sequence of heart muscle contraction and relaxation 220
The rhythmic contraction of the heart is due to its internal conduction system 221
An electrocardiogram is a recording of the electrical activities of the heart 222
Blood pressure is the force blood exerts against blood vessel walls 223
Cardiovascular Disease Is a Major Killer in the United States 225
High blood pressure can kill without producing symptoms 225
Atherosclerosis is a buildup of lipids in the artery walls 225
Coronary artery disease is atherosclerosis in the coronary arteries 227
Heart attack is the death of heart muscle 228
The Lymphatic System Functions in the Circulatory and Immune Systems 229
Health Issue: The Cardiovascular Benefits of Exercise 226
Body Defense Mechanisms 234
The Body's Defense System Targets Pathogens and Cancerous Cells 235
The Body Has Three Lines of Defense 235
The first line of defense consists of physical and chemical barriers that prevent entry of pathogens 235
The second line of defense includes defensive cells and proteins, inflammation, and fever 236
The third line of defense, the immune response, has specific targets and memory 240
The Immune System Distinguishes Self from Nonself 240
The Immune System Mounts Antibody-Mediated Responses and Cell-Mediated Responses 241
The Cell-Mediated Immune Response and the Antibody-Mediated Immune Response Have the Same Steps 242
B cells mount an antibody-mediated immune response against antigens free in the blood or bound to a cell surface 245
Cytotoxic T cells mount a cell-mediated defense against antigen-bearing cells 246
Immunological memory permits a more rapid response on subsequent exposure to the antigen 247
Suppressor T cells turn off the immune response 248
Immunity Can Be Active or Passive 248
Monoclonal Antibodies Are Used in Research, Clinical Diagnosis, and Disease Treatment 248
The Immune System Can Cause Problems 249
Autoimmune disorders occur when the immune system attacks the body's own cells 249
Allergies are immune responses to harmless substances 250
Health Issue: The Fear That Vaccines Cause Autism 249
Health Issue: Rejection of Organ Transplants 250
Special Topic: Infectious Disease 256
Pathogens Are Disease-Causing Organisms 257
Certain bacteria produce toxins that cause disease 257
Viruses can damage the host cell when they leave the cell after replication or when they are incorporated into the cell's chromosomes 259
Protozoans cause disease by producing toxins and enzymes 261
Fungi often cause disease by secreting enzymes that digest cells 262
Parasitic worms cause disease by releasing toxins, feeding off blood, or competing with the host for food 262
Prions induce disease by causing normal proteins to become misfolded and clump together 262
Disease Is Spread When a Pathogen Enters the Body through Contact, Consumption, or a Vector 263
Infectious Diseases Remain a Cause for Concern 265
New diseases are emerging, and some old diseases are reappearing 265
Epidemiologists track diseases 267
The Respiratory System 268
In the Respiratory System, Oxygen and Carbon Dioxide Are Exchanged across a Moist Body Surface 269
The nose filters and conditions incoming air and has receptors for the sense of smell 270
The sinuses lighten the head and condition inhaled air 271
The pharynx is a passageway for food and air 272
The larynx is an adjustable entryway that produces the voice 272
The trachea is the windpipe 273
The bronchial tree is a system of air tubules that conducts air 273
The alveoli of the lungs are surfaces for gas exchange 274
Pressure Changes within the Lungs Cause Breathing 275
Inhalation occurs when the pressure in the lungs decreases 275
Exhalation occurs when the pressure in the lungs increases 275
The volume of air moved into and out of the lungs is an indication of health 276
Blood Transports Gases between the Lungs and the Cells 277
Most oxygen is carried by hemoglobin 277
Most carbon dioxide is transported as bicarbonate ions 277
Breathing Is Controlled Primarily by Respiratory Centers in the Brain 278
Brain centers control the basic breathing pattern 278
Depth and rate of breathing are affected by chemoreceptors 278
Respiratory Disorders Have Many Causes 280
The common cold is caused by many types of viruses 280
The flu is caused by three types of viruses 280
Pneumonia is an inflammation of the lungs 280
Strep throat can have serious consequences 280
Tuberculosis causes tubercles to form in the lungs 283
Bronchitis is an inflammation of the bronchi 283
Emphysema is caused by the destruction of alveoli 283
Social Issue: Bird Flu, Will It Become a Pandemic? 281
Health Issue: Surviving a Common Cold 282
Environmental Issue: Air Pollution and Human Health 284
Special Topic: Smoking and Disease 287
Smoking Is the Leading Cause of Death in the United States 288
Cigarette Smoke Contains Poisons and Cancer-Causing Substances 288
Smoking Causes Several Deadly Diseases 289
Smoking causes lung disease 289
Smoking causes cancer 290
Smoking causes heart disease 292
Smoking causes other health problems 292
Smoking Poses Additional Health Risks for Women 292
Passive Smoking Causes Serious Health Problems 293
No Cigarette Is Safe 294
The Health Benefits of Quitting Smoking Are Numerous 294
The Digestive System 296
The Digestive System Consists of a Long Tube That Runs through the Body, Along with Accessory Glands 297
The Digestive System is Divided into Specialized Compartments for Food Processing 297
The mouth begins mechanical digestion and the chemical digestion of starch 297
The pharynx is shared by the digestive and respiratory systems 300
The esophagus conducts food from the pharynx to the stomach 300
The stomach stores and liquefies food and begins protein digestion 300
The small intestine is the primary site of digestion and absorption 302
The pancreas, liver, and gallbladder are accessory organs that aid the processes of digestion and absorption within the small intestine 304
The large intestine absorbs water and other useful substances 308
Nerves and Hormones Control Digestive Activities 310
Health Issue: Heartburn and Peptic Ulcers-Those Burning Sensations 307
Special Topic: Nutrition and Weight Control 313
MyPyramid Is a Food Guide for Planning a Healthy Diet 314
Nutrients Provide Energy or Have a Structural or Functional Role in the Body 314
Lipids include fats, oils, and cholesterol 314
Carbohydrates include sugars, starches, and dietary fiber 317
Proteins are chains of amino acids 319
Vitamins are needed in small amounts to promote and regulate the body's chemical reactions 320
Minerals play structural and functional roles in the body 322
Water is critical and needed in large amounts 323
Food Labels Help Us Make Wise Food Choices 323
For Body Energy Balance, Calories Gained in Food Must Equal Calories Used 323
Obesity is Body Weight 20% or More above the Body Weight Standard 325
Successful Weight-Loss Programs Usually Involve Reducing Calorie Intake, Increasing Calorie Use, and Changing Behavior 325
Anorexia Nervosa and Bulimia Are Eating Disorders That Create Calorie Deficits 327
The Urinary System 329
Organs from Several Body Systems Eliminate Waste 330
By Producing Urine, the Kidneys Maintain Homeostasis 331
Each kidney has three regions 331
Nephrons are the functional units of the kidneys 331
The kidneys help maintain acid-base balance 336
The kidneys help conserve water 336
Hormones influence kidney function 337
The kidneys help produce red blood cells and activate vitamin D 338
Dialysis and Transplant Surgery Help When Kidneys Fail 339
Dialysis cleanses the blood 339
Renal function can be restored with a kidney transplant 342
Urination Has Involuntary and Voluntary Components 343
Bacteria Can Enter the Urethra and Cause Urinary Tract Infections 345
Health Issue: Kidney Stones and Their Shocking Treatment 340
Health Issue: Urinalysis: What Your Urine Says about You 344
Reproduction
Reproductive Systems 349
The Gonads Produce Gametes and Sex Hormones 350
A Male's Reproductive Role Differs from a Female's 350
The Male Reproductive System Delivers Sperm to the Egg 350
The testes produce sperm and male hormones 351
The duct system stores and transports sperm 352
The accessory glands produce most of the volume of semen 352
The penis transfers sperm to the female 353
As sperm develop, changes occur in the number of chromosomes and the structure and function of cells 353
The interplay of hormones controls male reproductive processes 354
The Female Reproductive System Produces the Eggs and Nurtures the Embryo and Fetus 355
The ovaries produce eggs and female hormones 355
The oviducts transport the immature egg, zygote, and early embryo 355
The uterus supports the growth of the developing embryo 355
External genitalia lie outside the vagina 357
The breasts produce milk to nourish the baby 357
The events of the ovarian cycle lead to release of an egg 357
The interplay of hormones coordinates the ovarian and menstrual cycles 358
Menopause ends a woman's reproductive cycles 362
Problems with the Female Reproductive System Vary in the Severity of Health Consequences 362
The Human Sexual Response Has Four Stages 364
Birth Control Is the Prevention of Pregnancy 364
Abstinence is refraining from intercourse 364
Sterilization may involve cutting and sealing gamete transport tubes 364
Hormonal contraception interferes with regulation of reproductive processes 365
Intrauterine devices prevent the union of sperm and egg and implantation 366
Barrier methods of contraception prevent the union of sperm and egg 366
Spermicidal preparations kill sperm 366
Fertility awareness is the avoidance of intercourse when fertilization could occur 367
The morning-after pill is emergency contraception 367
Health Issue: Breast Cancer 358
Environmental Issue: Environmental Estrogens 363
Special Topic: Sexually Transmitted Diseases and AIDS 370
STDs Are Extremely Common and Can Have Long-Lasting Effects 371
STDs Caused by Bacteria Can Be Cured with Antibiotics 371
Chlamydia can cause pain during urination, PID, or no symptoms 371
Gonorrhea can cause pain during urination, PIG, or no symptoms 372
Syphilis can progress though three stages when untreated 373
STDs Caused by Viruses Can Be Treated but Not Cured 373
Genital herpes can cause painful, fluid-filled blisters 374
Genital warts can lead to cervical, penile, or anal cancer 375
An HIV Infection Progresses to AIDS 376
HIV/AIDS is a global epidemic 377
HIV consists of RNA and enzymes encased in a protein coat 377
HIV enters the cells, rewrites its RNA as DNA, inserts DNA into the host chromosome, and replicates 377
Most HIV is transmitted through sexual contact, intravenous drug use, or from a pregnant woman to her fetus 377
Sites of HIV infection include the immune system and the brain 379
An HIV infection progresses through several stages as helper T cell numbers decline 379
Treatments for HIV infection are designed to block specific steps in HIV's replication cycle 381
Development throughout Life 382
Human Life Has Two Main Periods of Development 383
The Prenatal Period Begins at Fertilization and Ends at Birth 383
Fertilization, cleavage, and implantation characterize the pre-embryonic period 383
Tissues and organs form during the embryonic period 388
Rapid growth charactetizes the fetal period 393
Birth Is the Transition from Prenatal to Postnatal Development 396
True labor has three stages 396
The placenta may send the signal to initiate labor 397
Drugs and breathing techniques can relieve pain during childbirth 397
Environmental Disruptions during the Embryonic Period Cause Major Birth Defects 398
The Mother's Mammary Glands Produce Milk 398
The Postnatal Period Begins with Birth and Continues into Old Age 399
Possible causes of aging 400
Medical advances and a healthy lifestyle can help achieve a high-quality old age 401
Health Issue: Making Babies, but Not the Old-Fashioned Way 389
Genetics and Development
Chromosomes and Cell Division 405
The Human Life Cycle Has Two Types of Cell Division 406
Chromosomes Consist of DNA and Protein 406
Our Cells Divide in a Characteristic Cyclic Pattern 407
Interphase is a period of growth and preparation for cell division 407
Division of body cells entails division of the nucleus and the cytoplasm 408
Mitosis has four stages 408
Cytokinesis occurs toward the end of mitosis 412
Meiosis Forms Haploid Gametes 412
Meiosis keeps the chromosome number constant over generations and increases genetic variability in the population 412
Meiosis involves two cell divisions 412
Crossing over and independent assortment cause genetic recombination during meiosis 417
Failure of chromosomes to separate during meiosis creates cells with extra or missing chromosomes 417
Health Issue: Turner Syndrome and Klinefelter Syndrome 420
Special Topic: Stem Cells-The Body's Repair Kit 424
Stem Cells Are Unspecialized Cells That Divide Continually and Can Be Made to Develop into Different Tissue Types 425
There Are Several Sources of Human Stem Cells 425
Embryonic stem cells can be harvested from unused embryos created for in vitro fertilization 425
Adult stem cells exist in many tissues 425
Stem cells can be harvested from umbilical cord blood 426
Embryonic stem cells can be created by somatic cell nuclear transfer 427
Embryonic Stem Cell Research Raises Ethical and Political Controversy 429
Genetics and Human Inheritance 430
Principles of Inheritance Help Us Predict How Simple Traits Are Passed to the Next Generation 431
During gamete formation, alleles segregate and assort independently 432
Mendelian genetics considers patterns of inheritance 432
Pedigrees help us to ascertain genotype 435
A dominant allele often produces a protein that the recessive allele does not 437
Codominant alleles both produce functioning gene products 437
In incomplete dominance, the heterozygote has an intermediate phenotype 437
In pleiotropy, one gene has many effects 438
Certain genes have multiple alleles in a population 438
Most traits are controlled by many genes 438
Genes on the same chromosome are usually inherited together 440
Sex-linked genes are located on the sex chromosomes 440
Sex-influenced genes are autosomal genes whose expression is influenced by sex hormones 441
Breaks in Chromosomes Change Chromosomal Structure and Function 441
Certain Genetic Disorders Can Be Detected by Laboratory Tests 441
Social Issue: Gene Testing 443
DNA and Biotechnology 447
DNA Is a Double Helix Consisting of Two Strings of Nucleotides 448
During Replication of DNA, Each Original Strand Serves as a Template for a New Strand 448
DNA Codes for RNA, Which Codes for Protein 449
Transcription is RNA synthesis 450
Translation is protein synthesis 451
Mutations Result from Nucleotide Substitution, Insertion, or Deletion 453
Gene Activity Can Be Turned On or Off 455
Coiling and uncoiling of chromosomes regulate gene activity at the chromosome level 455
Certain genes regulate the activity of other genes 455
Chemical signals regulate gene activity 455
Genetic Engineering Is the Manipulation of DNA for Human Purposes 456
Recombinant DNA is made of DNA from different sources 456
Genetic engineering produces proteins of interest or transgenic organisms with desirable traits 458
Gene therapy replaces faulty genes with functional genes 460
Genomics Can Be Used to Study How Genes Function and How Diseases Are Inherited 463
The Human Genome Project sequenced a representative human genome 463
Microarray analysis is a useful tool in genomics 464
Comparing genomes of different species can be useful 464
Health Issue: Genetically Modified Food 461
Social Issue: Forensic Science, DNA, and Personal Privacy 465
Special Topic: Cancer 468
Cancer Is Uncontrolled Cell Division 469
Tumors can be benign or malignant 469
Tumor development progresses through stages 469
Cancer Begins with a Single Cell That Escapes Normal Control Mechanisms 470
Cancer cells lose restraints on cell division 471
Cancer cells do not self-destruct when their DNA is damaged 472
Cancer cells divide indefinitely 473
Cancer cells attract a blood supply 473
Cancer cells do not adhere to neighboring cells 474
Body defense cells destroy cancer cells 474
Viruses, Certain Chemicals, and Radiation Can Cause Cancer 475
Certain viruses can disrupt genetic control of cell division 475
Some chemicals can cause mutations 475
Radiation can cause mutations 475
Certain Lifestyle Habits Reduce the Risk of Cancer 475
There Are Several Ways to Diagnose Cancer 477
Surgery, Radiation, and Chemotherapy Are Conventional Ways to Treat Cancer 478
Surgery is used to remove tumors 478
Radiation therapy is used to kill localized cancer cells 478
Chemotherapy is used to kill cancer cells throughout the body 478
Immunotherapy boosts immune responses against cancer cells 478
Inhibition of blood vessel formation may slow the spread of cancer cells 479
Gene therapy may someday help fight cancer in several ways 479
Evolution and Ecology
Evolution and Our Heritage 480
Life Evolved on the Earth about 3.8 Billion Years Ago 481
Inorganic molecules formed small organic molecules 481
Small organic molecules joined to form larger molecules 481
Macromolecules aggregated into droplets 482
The Scale of Evolutionary Change May Be Small or Large 483
Microevolution is small-scale evolutionary change over short periods of time 483
Macroevolution is large-scale evolutionary change over long periods of time 485
Evidence of Evolution Comes from Diverse Sources 486
The fossil record provides evidence of evolution 486
Geographic distributions reflect evolutionary history 488
Comparative anatomy and embryology reveal common descent 488
Comparative molecular biology also reveals evolutionary relationships 489
Human Roots Trace Back to the First Primates 489
Primates have distinct characteristics 490
Discussions of human origins often evoke controversy 493
Misconceptions distort the picture of human evolution 493
Walking on two feet was a critical step in hominid evolution 494
Social issue: Conducting Research on Our Relatives 492
Ecology, the Environment, and Us 501
The Earth Is a Closed Ecosystem with Energy as the Only Input 502
The Biosphere Is the Part of the Earth Where Life Exists 502
Ecological Succession Is the Change in Species Occupying a Given Location over Time 502
Energy Flows through Ecosystems from Producers to Consumers 503
Food chains and food webs depict feeding relationships 503
Energy is lost as it is transferred through trophic levels 505
Ecological pyramids depict energy or biomass at each trophic level 505
Ecological pyramids have health and environmental ramifications 505
Chemicals Cycle through Ecosystems 509
Water cycles between the atmosphere and land 509
Carbon cycles between the environment and living bodies 509
Nitrogen cycles through several nitrogenous compounds 511
Phosphorus cycles between rocks and living organisms 512
Humans Can Upset Biogeochemical Cycles 512
Humans sometimes cause shortage or pollution of water 513
Atmospheric levels of carbon dioxide affect global temperatures 514
Disruptions to the nitrogen and phosphorus cycles can cause eutrophication 515
Environmental Issue: Global Warming 516
Human Populations, Limited Resources, and Pollution 519
Populations Change in Size over Time 520
Rates of addition and subtraction determine population growth rate 520
The age structure of a population influences future growth 520
Immigration and emigration affect population size 521
The Human Population Is Increasing, but Its Rate of Growth Is Slowing 521
Environmental Factors Regulate Population Size 522
The Growing Human Population Has Altered the Earth's Carrying Capacity 523
The human population may be reaching the earth's carrying capacity 523
Human activities cause pollution 524
Human activities deplete the earth's resources 525
Human activities are reducing biodiversity 525
Our Future Depends on the Decisions We Make Today 527
Social Issue: Maintaining Our Remaining Biodiversity 526
Glossary G-1
Illustration Credits C-1
Metric-English System Conversions A-1
Selected Answers to Reviewing the Concepts Questions A-3
Hints for Applying the Concepts Questions A-5
Index I-1
Preface
Humans are, by nature, curious, and this book is intended to stimulate the curiosity of nonscience students toward gaining an appreciation for the intricacy of human life and our place in the ecosphere. Once piqued, curiosity must rely upon conceptual substance for understanding. We inform students by building a conceptual framework that allows them to better understand their everyday experiences with their bodies and with the world around them. Connections between biological concepts and social issues and the application of these concepts to familiar experiences will support you in your classroom instruction and discussion by helping students see the importanceand excitementof science in their lives.
The first goal of this textbook is to present the important concepts of human anatomy, physiology, development, genetics, evolution, and ecology. Then, after thoroughly explaining the basic concepts, we apply them in ways that will both interest and benefit the student. For example, a discussion of Alzheimer's disease, depression, and Parkinson's disease follows an explanation of neurotransmitters. When the content is relevant, it gives students a reason to want to learn the information. The chapters on organ systems explain how a healthy system functions, how that system might malfunction, measures to avoid a malfunction, and what current medicine can offer when systems are compromised or fail. Topics that students are likely to encounter in the media on an almost daily basissmoking, contraception, STDs, cancer, bioterrorism, antibiotic-resistant bacteriawill help students make connections between real-life and classroom activities. Connectionsbetween concepts and environmental issues will help students develop a global perspective about environmental issues.
This text answers some very practical questions, including: What type of exercise benefits the heart? How does someone cope with insomnia? How does one protect against unwanted pregnancy and prevent the spread of sexually transmitted diseases? Each of us enters this world with a most intricate machineour bodybut we do not come equipped with an owner's manual. In a sense, this book can be the student's owner's manual. Understanding the information in it and applying it to our own lifestyles and health choices can help each of us live longer, happier, and more productive lives.
The second goal is to help students develop reasoning skills, so they can use the information in situations they face every day in life. Woven throughout each chapter are "stop and think" questions that ask students to apply information to a new situation. When a topic or issue is controversial, the discussion presents both sides of the argument, together with the supporting evidence. Scattered throughout each chapter are "what would you do?" questions that ask the student's opinion or challenge the student to take a stand on a particular issue as well as to identify the criteria used in reaching that decision. These questions foster the practice of thinking through issues, examining the information available, and making; decisions based on that information. Additional critical-thinking; questions reside on the Companion Web Site.
The third goal is to help students understand how the choices they make can affect the quality of life for themselves, society, and the planet. The material learned in the textbook or during lecture often bears on social or environmental issues that are important to us all. This text will help you, as the instructor, heighten students' awareness of their impact on the biosphere and prepare students to be responsible citizens and voters. Society is currently grappling with many pressing biological issuesthe cloning of human cells, stem cell research, genetically modified foods, gene therapy, organ transplants, defining death, dealing with bioterrorism, and preventing and treating HIV infections, among othersand students need the tools to understand these issues and make informed decisions about them.
To reach these three goals, the text engages the student with applications that will interest them personally and discussions of critical issues facing society. The writing makes the information easily accessible. Each chapter begins with an outline of the major section headings to provide a preview and a framework upon which concepts are developed. These section headings are presented as complete sentences that clearly state the main concept of each section. Illustrated tables offer a way to organize and summarize information to help students see the big picture as well as the details.
The visual program stimulates learning with simple, beautiful illustrations that are supported and enhanced by effective pedagogy. Vibrant, three-dimensional figures show appropriate depth and detail and are clearly accessible and understandable for your students. The illustrationsincluding molecules and human tissues and organsare visually consistent in form and structure throughout the text. "Voice balloons" draw the student's attention to a particularly important process or teaching point in many of the figures. Key figures pull concepts together to present the big picture. For example, the chapters on organ systems include figures that show both the anatomical structure and the function of the components of each system. These figures, such as Figure 14.2 of the respiratory system, help students understand the important relationship between structure and function. Micrographs paired with illustrations help students more easily interpret the micrograph by comparing it with the coupled illustration. Reference figures help students locate a particular structure within the body. Figure 4.2, which illustrates types of connective tissue, is an example that pairs micrographs to illustrations and also shows the student where each type of connective tissue is found. Many illustrations provide surrounding context for the particular structure being examined. For example, Figure 8.3., a sagittal section through the brain, includes the surrounding facial features and an illustration of a head to indicate orientation and perspective. Flowcharts visually walk students h rough a process so they can follow the discussion step by step as it moves through a sequence of explanations. Difficult concepts are presented using step-by-step figures, with a brief explanation of each step. By breaking a difficult concept into smaller components, such figures help the student understand each step and see how the steps fit together. For example, Figure 9.13 guides the student through i4e sequence of events involved in hearing, from sound waves hitting the eardrum to the brain's interpretation of neural information from the ear.
Finally, color is used in the visual program to effectively organize information. Where appropriate, color delineates the steps in a process. For example, in Figure 13.15, subtle differences in background shading distinguish different steps in the immune response. In Figure 12.13, a depiction of the electrical activity of the heart, color indicates the progress of a process.
How the Book Is Organized
The text begins with a discussion of the chemistry of life and then moves to cells, tissues, organs, organ systems, and finally to populations and ecosystems. Rarely is it possible to cover all the topics in a human biology text in one semester. Instructors must make difficult decisions about what to include and the order of presentation, and there are many excellent ways of presenting the material. For this reason, the chapters in this text do not depend heavily on material covered in earlier chapters. The independence of chapters allows you to tailor the use of this text to your course. Cross-references are given to direct students to relevant discussions in other chapters.
Features of the Book
CHAPTER OUTLINES
Each chapter begins with an outline that provides a framework upon which the student can organize the information presented. An outline identifies the important concepts and serves as a map of the relationships among these concepts.
SPECIAL TOPIC CHAPTERS
The Special Topic chapters (8a, Drugs and the Mind; 13a, Infectious Disease; 14a, Smoking and Disease; 15a, Nutrition and Weight Control; 17a, Sexually Transmitted Diseases and AIDS; and 21 a, Cancer) expand "pure biology" to cover issues that are likely to be of personal interest and therefore motivating to students. The topics address personal health issues and are more thoroughly developed than they could be in an essay. Even if you do not assign these special topics for students to read, we hope that the issues are so pertinent that they will read or at least refer to these chapters as guides to healthier lifestyles.
"STOP AND THINK" QUESTIONS
"Stop and think" questions are scattered throughout each chapter and are intended to engage students in the learning process and to promote active learning. They invite the student to pause, think about the concept explained, and apply that information to a new situation. They provide periodic checks for the student to determine whether he or she understands the basic concepts.
"WHAT WOULD YOU DO?" QUESTIONS
"What would you do?" questions are also scattered throughout each chapter and raise ethical questions about issues that society faces today. These help the student see the relevance of information learned in a biology classroom to real-life problems or decisions that society must make, including fluoridation of water, routine screening for prostate cancer, the use of animal organs to save human lives, the export of pesticides to developing countries, and the means of slowing the growth of human populations. There is no right answer to any of these questions. They simply point out to the student that there are broad implications to many of the topics discussed. You may choose to use these questions to begin a classroom presentation, to stimulate discussions, or as questions to leave students thinking about a topic outside the classroom.
ESSAYS
The essays apply information and focus on health, social, or environmental issues. Instructors might use these essays to engage students in the classroom or to provide them with information needed for informed in-class discussions. Health Issue essays deal primarily with personal health topics. They provide current information on certain health problems that they, their family, or their friends might encounter. Some of the topics discussed in Health Issue essays are acne, osteoporosis, treatments for the common cold, and heartburn. These essays will help students better understand what their physicians may be telling them. The Social Issue essays explore some of the ethical or social issues related to the topics under consideration. The topics of Social Issue essays include anabolic steroids, gene testing, stem cells, and cloning. Finally, the Environmental Issue essays deal with the ways in which human activities alter the environment or the ways in which the environment influences human health or well-being. Among the topics discussed in Environmental Issues essays are acid rain, asbestos, noise pollution, and global warming.
Pedagogical Features
When students are studying outside the classroom, this text will help them understand the concepts presented during lecture. Some of the features are designed to reinforce details and others to reinforce concepts that were presented in class.
Headings and Summaries. The headings are presented as sentences, which state the main point of the sections that follow. Thus, students see the big picture and focus on the explanations that follow. The Reviewing the Concepts summary sections are organized using the main headings of the chapter. Relevant page numbers are included to guide a student from the summary of a topic back to the hill text discussion of that topic.
Key Terms and Glossary. This text minimizes technical language because it is intended for students who are not science majors. 1'loneth~ss, some terms must be used even though they may not be familiar t~ students. The important terms are boldfaced throughout the chapter and are listed as key terms at the end of the chapter. This list also provides chapter page numbers, indicating where each term is defined. A glossary at the end of the book includes all key terms used in the book.
Questions. The questions posed at the end of each chapter have a variety of formats. Some are simply for content review; others require more critical thinking to apply the information to new situations. Review questions that require a written answer are followed by the page number of the relevant discussion. This practice will engage students in the learning process by encouraging them to review and understand the relevant material instead of memorizing the answer. Answers to the multiple-choice and fill-in questions are provided in an appendix. Hints for answering the Applying the Concepts questions are also included in an appendix. These hints help students identify the information needed to answer each question; instead of providing a quick answer, the hints guide a student's thinking process.
Icons. Icons in the book direct the student to Web tutorials on the Web Site for this text. The Web tutorials cover processes and difficult concepts with animations, interactive exercises, and a quiz to help students assess their understanding of the topic after viewing the animation or completing the exercise.
Relevant Web Sites. The front inside text cover lists 160 relevant and useful Web Sites for students who want to explore a topic in more detail. Because the text discusses many health issues that students or their families and friends may face, the list of Web Sites includes resources that can provide support for people with various health problems, including cancer, drug and alcohol abuse, and smoking.