Designing Clinical Research
Selected as a Doody's Core Title for 2022 and 2023!


For more than 30 years, Designing Clinical Research has set the standard as the most practical, authoritative guide for physicians, nurses, pharmacists, and other practitioners involved in all forms of clinical and public health research. Using a reader-friendly writing style, Drs. Warren S. Browner, Thomas B. Newman, Steven R. Cummings, Deborah G. Grady, Alison J. Huang, Alka M. Kanaya, and Mark J. Pletcher, all of the University of California, San Francisco, provide up-to-date, commonsense approaches to the challenging judgments involved in designing, funding, and implementing a study. This state-of-the-art fifth edition features new figures, tables, and design, as well as new editors, new content, and extensively updated references to keep you current.

  • Covers clinical research in its many forms, including clinical trials, observational studies, translational science, and patient-oriented research.

  • Presents epidemiologic terms and principles and advanced conceptual material in a practical and reader-friendly manner.

  • Discusses key changes in the field, including confounding and directed acyclic graphs, surrogate outcomes and biomarkers, instrumental variables and Mendelian randomization, regression discontinuity designs, alternative data sources, AI and machine learning, pilot studies, as well as an update on P values and Bayesian analysis..

  • Covers modifications of classic randomized trials, such as pre/post, interrupted time series, difference-in-differences, stepped wedge and cluster randomized designs, as well as randomized trials in health systems.

  • Adds new chapters on qualitative approaches to clinical research and on community-engaged research
     

    Enrich Your eBook Reading Experience

  • Read directly on your preferred device(s),such as computer, tablet, or smartphone

  • Easily convert to audiobook,powering your content with natural language text-to-speech

1140546702
Designing Clinical Research
Selected as a Doody's Core Title for 2022 and 2023!


For more than 30 years, Designing Clinical Research has set the standard as the most practical, authoritative guide for physicians, nurses, pharmacists, and other practitioners involved in all forms of clinical and public health research. Using a reader-friendly writing style, Drs. Warren S. Browner, Thomas B. Newman, Steven R. Cummings, Deborah G. Grady, Alison J. Huang, Alka M. Kanaya, and Mark J. Pletcher, all of the University of California, San Francisco, provide up-to-date, commonsense approaches to the challenging judgments involved in designing, funding, and implementing a study. This state-of-the-art fifth edition features new figures, tables, and design, as well as new editors, new content, and extensively updated references to keep you current.

  • Covers clinical research in its many forms, including clinical trials, observational studies, translational science, and patient-oriented research.

  • Presents epidemiologic terms and principles and advanced conceptual material in a practical and reader-friendly manner.

  • Discusses key changes in the field, including confounding and directed acyclic graphs, surrogate outcomes and biomarkers, instrumental variables and Mendelian randomization, regression discontinuity designs, alternative data sources, AI and machine learning, pilot studies, as well as an update on P values and Bayesian analysis..

  • Covers modifications of classic randomized trials, such as pre/post, interrupted time series, difference-in-differences, stepped wedge and cluster randomized designs, as well as randomized trials in health systems.

  • Adds new chapters on qualitative approaches to clinical research and on community-engaged research
     

    Enrich Your eBook Reading Experience

  • Read directly on your preferred device(s),such as computer, tablet, or smartphone

  • Easily convert to audiobook,powering your content with natural language text-to-speech

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Overview

Selected as a Doody's Core Title for 2022 and 2023!


For more than 30 years, Designing Clinical Research has set the standard as the most practical, authoritative guide for physicians, nurses, pharmacists, and other practitioners involved in all forms of clinical and public health research. Using a reader-friendly writing style, Drs. Warren S. Browner, Thomas B. Newman, Steven R. Cummings, Deborah G. Grady, Alison J. Huang, Alka M. Kanaya, and Mark J. Pletcher, all of the University of California, San Francisco, provide up-to-date, commonsense approaches to the challenging judgments involved in designing, funding, and implementing a study. This state-of-the-art fifth edition features new figures, tables, and design, as well as new editors, new content, and extensively updated references to keep you current.

  • Covers clinical research in its many forms, including clinical trials, observational studies, translational science, and patient-oriented research.

  • Presents epidemiologic terms and principles and advanced conceptual material in a practical and reader-friendly manner.

  • Discusses key changes in the field, including confounding and directed acyclic graphs, surrogate outcomes and biomarkers, instrumental variables and Mendelian randomization, regression discontinuity designs, alternative data sources, AI and machine learning, pilot studies, as well as an update on P values and Bayesian analysis..

  • Covers modifications of classic randomized trials, such as pre/post, interrupted time series, difference-in-differences, stepped wedge and cluster randomized designs, as well as randomized trials in health systems.

  • Adds new chapters on qualitative approaches to clinical research and on community-engaged research
     

    Enrich Your eBook Reading Experience

  • Read directly on your preferred device(s),such as computer, tablet, or smartphone

  • Easily convert to audiobook,powering your content with natural language text-to-speech


Product Details

ISBN-13: 9781975174408
Publisher: LWW
Publication date: 05/19/2022
Edition description: Fifth
Pages: 468
Sales rank: 1,058,276
Product dimensions: 7.00(w) x 10.00(h) x (d)

Table of Contents

Contributing Authors ix

Introduction xi

Acknowledgments xiii

Section I Basic Ingredients 1

1 Getting Started: The Anatomy and Physiology of Clinical Research Warren S. Browner Thomas B. Newman Mark J. Pletcher 2

2 Conceiving the Research Question and Developing the Study Plan Steven R. Cummings Alka M. Kanaya 17

3 Choosing the Study Participants: Specification, Sampling, and Recruitment Warren S. Browner Thomas B. Newman Mark J. Pletcher 26

4 Planning the Measurements: Precision, Accuracy, and Validity Steven R. Cummings Thomas B. Newman Alison J. Huang 39

5 Getting Ready to Estimate Sample Size: Hypotheses and Underlying Principles Warren S. Browner Thomas B. Newman Mark J. Pletcher 52

6 Estimating Sample Size: Applications and Examples Warren S. Browner Thomas B. Newman Mark J. Pletcher 65

7 Addressing Ethical Issues Bernard Lo Deborah G. Grady 95

Section II Study Designs 115

8 Designing Cross-Sectional and Cohort Studies Thomas B. Newman Warren S. Browner Steven R. Cummings 116

9 Designing Case-Control Studies Thomas B. Newman Warren S. Browner 138

10 Estimating Causal Effects Using Observational Studies Thomas B. Newman Warren S. Browner 157

11 Designing Randomized Blinded Trials Steven R. Cummings Deborah G. Grady Alison J. Huang 196

12 Alternate Interventional Study Designs Deborah G. Grady Steven R. Cummings Alison J. Huang 221

13 Designing Studies of Medical Tests Thomas B. Newman Michael A. Kohn Warren S. Browner Mark J. Pletcher 240

14 Qualitative Approaches in Clinical Research Daniel Dohan 263

Section III Approaches and Implementation 281

15 Community-Engaged Research Alka M. Kanaya 282

16 Research Using Existing Data or Specimens Mark J. Pletcher Deborah G. Grady Steven R. Cummings 291

17 Designing, Selecting, and Administering Self-Reported Measures Alison J. Huang Steven R. Cummings Michael A. Kohn 307

18 Study Implementation and Quality Control Deborah G. Grady Alison J. Huang 323

19 Data Management Michael A. Kohn Thomas B. Newman 340

20 Writing a Proposal for Funding a Research Study Steven R. Cummings Deborah G. Grady Alka M. Kanaya 353

Answers to the Exercises at the Ends of Chapters 369

Glossary 395

Index 437

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