The refinement of a chemical process to the point where it becomes both cost and time efficient can be seen as "art." In a competitive environment where pharmaceutical companies are under ever increasing pressure to bring new drugs more quickly to the market, ways need to be found to provide bulk supplies of drug candidates as quickly as possible and to design manufacturing routes, which are robust, economical and environmentally firendly. This monograph is divided into 9 chapters, each one concentrating on a single class of drug candidates of chemistry development and describing the routes explored and the optimizations made to each drug candidate, inluding the discovery of applicable new chemistry and the elucidation of reaction mechanism.
1100408509
From the contents:
- Efairenz®, a Non-Nucleoside Reverse Transciptase Inhibitor (NNRTI), and a Previous Structurally Related Development Candidate
- CCR5 Receptor Antagonist
- 5α-Reductase Inhibitors – The Finsteride Story
- Rizatriptan (Maxalt®): A 5-HT1D Receptor Agonist
- SERM: Selective Estrogen Receptor Modulator
- HIV Integrase Inhibitor: Raltegravir
- Cyclopentane-Based NK1 Receptor Antagonist
- Glucokinase Activator
- CB1R Inverse Agonist – Taranabant
The Art of Process Chemistry
The refinement of a chemical process to the point where it becomes both cost and time efficient can be seen as "art." In a competitive environment where pharmaceutical companies are under ever increasing pressure to bring new drugs more quickly to the market, ways need to be found to provide bulk supplies of drug candidates as quickly as possible and to design manufacturing routes, which are robust, economical and environmentally firendly. This monograph is divided into 9 chapters, each one concentrating on a single class of drug candidates of chemistry development and describing the routes explored and the optimizations made to each drug candidate, inluding the discovery of applicable new chemistry and the elucidation of reaction mechanism.
From the contents:
- Efairenz®, a Non-Nucleoside Reverse Transciptase Inhibitor (NNRTI), and a Previous Structurally Related Development Candidate
- CCR5 Receptor Antagonist
- 5α-Reductase Inhibitors – The Finsteride Story
- Rizatriptan (Maxalt®): A 5-HT1D Receptor Agonist
- SERM: Selective Estrogen Receptor Modulator
- HIV Integrase Inhibitor: Raltegravir
- Cyclopentane-Based NK1 Receptor Antagonist
- Glucokinase Activator
- CB1R Inverse Agonist – Taranabant
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The Art of Process Chemistry
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Product Details
ISBN-13: | 9783527633586 |
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Publisher: | Wiley |
Publication date: | 12/01/2010 |
Sold by: | JOHN WILEY & SONS |
Format: | eBook |
Pages: | 298 |
File size: | 11 MB |
Note: | This product may take a few minutes to download. |
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