Table of Contents

Epidemiology The metabolic syndrome: definitions, controversies, and clinical utility. Lewis W Johnson MD, Ruth S Weinsk MD, PhD Epidemiology of the Metabolic syndrome and related disorders in children and adolescents – Jennifer L Foltz MD, Stephen R Cook MD, MPH Metabolic syndrome in children and adolescents worldwide – Orit Pinhas-Hamiel MD Maternal-fetal contributors to the insulin resistance syndrome in youth – Dana Dabelea MD, PhD Early childhood contributions to insulin resistance – David B Dunger MD, FRCP, FRCPCH, Burak Salgin, Ken K Ong MRCPCH PhD Pathophysiology Molecular Mechanisms of insulin resistance - Boris Draznin MD, PhD Techniques used to assess insulin action – Michael J Pagliassotti PhD, Kyle T. Pfaffenbach MS, Tracy J. Horton Adiposity is the enemy: body composition and insulin sensitivity – J Higgins PhD, William T Donahoo MD Ectopic fat deposition: adiponectin and insulin resistance in obese adolescents – Anna MG Cali MD, Sonia Caprio MD Mediators of insulin resistance - Rocio Periera MD, David Maahs MD Insulin resistance and the pathogenesis of cardiovascular disease. – Ramzi Ajjan MRCP, MMed.Sci, PhD, Mark T Kearn FRCP, PhD, Peter T Grant FRCP, MD Insulin Resistance and Cardiovascular disease: Cecilia C Low Wang MD The liver and insulin resistance: the important convergence of endocrinology and hepatology – Charissa Y Chang, MD , Kerry Whitt MD, Zhenqi Liu MD, Stephen H Caldwell MD Polycystic Ovarian Syndrome and metabolic syndrome: Marie-Helene. Pesant MD, Jean-Patrice BaillargeonMD Treatment Effects of Exercise in Metabolic Syndrome and Diabetes: A Central Role for Insulin Sensitivity – Irene E Schauer MD, PhD, Judith.G. Regensteiner PhD, Jane EB. Reusch MD Weight loss medications and the metabolic syndrome – Linda Buckley MD, Daniel Bessessen MD.