Scientists are now recognizing the value of employing compounds already produced by the body as therapeutic agents. SAMe is such a compound. Its use for detoxification, depression, osteoarthritis, Parkinson's disease, Alzheimer Disease, liver disease and fibromyalgia is gaining credibility as more and more clinical studies emerge. In this booklet, Rita Elkins, MH, provides a comprehensive outline of the amazing capabilities of SAMe, as well as its history and safety.