Table of Contents

Foreword
Preface
Part I: PRINCIPLES OF GERONTOLOGY
1. Biology of Aging and Longevity, Richard A. Miller
2. Genetics of Age-Dependent Human Disease, Thomas B.L. Kirkwood
3. Immunology and Aging, Birgit Weinberger, Daniela Weiskopf, and Beatrix Grubeck-Loebenstein
4. Inflammation and Aging, Jeremy D. Wilson
5. Demography and Epidemiology, Jack M. Guralnik and Luigi Ferrucci
6. International Gerontology, Roberto Bernabei, Len Gray, John Hirdes, Xiaomei Pei, Jean Claude Henrard, Palmi V. Jonsson, Graziano Onder, Giovanni Gambassi, Naoki Ikegami, Annette Hylen Ranhoff, Iain G. Carpenter, Rowan H. Harwood, Brant E. Fries, John N. Morris, and Knight Steel
7. Psychosocial Aspects of Aging, Richard Schulz and Steven M. Albert
8. General Principles of Pharmacology, Sarah N. Hilmer and Gary A. Ford
9. Preventive Gerontology: Strategies for Optimizing Health Across the Life Span, Elizabeth A. Phelan, Miguel A. Paniagua, and William R. Hazzard
Part II: PRINCIPLES OF GERIATRICS
10. Evaluation, Management, and Decision Making with the Older Patient, Sharon E. Straus and Mary E. Tinetti
Section A: Assessment
11. Principles of Geriatric Assessment, David B. Reuben and Sonja Rosen
12. Mental Status and Neurological Examination in Older Adults, James E. Galvin
13. Assessment of Decisional Capacity and Competencies, Margaret A. Drickamer and James M. Lai
14. Principles of Screening in Older Adults, Louise C. Walter
Section B: Organization of Care
15. Health Care System, Chad Boult
16.Transitions, William L. Lyons and Eric A. Coleman
17. Acute Hospital Care, Scott A. Flanders, Paula M. Podrazik, Chad Whelan, and Caroline Blaum
18. Emergency Department Care, Scott T. Wilber and Lowell W. Gerson
19. Critical Care in the Elderly, Eric B. Milbrandt and Derek C. Angus
20. Subacute Care, Edward R. Marcantonio and Mark Yurkofsky
21. Nursing Facility Care, Mary Pat Rapp and Keith L. Rapp
22. Community-Based Long-Term Care and Home Care, Jennifer Hayashi and Bruce Leff
23. Rural Aging, Kenneth Brummel-Smith
Section C: Special Management Issues
24. Appropriate Approach to Prescribing, Paula A. Rochon, Jennifer Tjia, Sudeep S. Gill, and Jerry H. Gurwitz
25. Complementary and Alternative Medicine in Aging, Joseph T. Hanlon, Marc R. Blackman, and Ronald M. Glick
26. Team Care, Ellen Flaherty, Kathryn Hyer, and Terry Fulmer
27. Social Work, Ruth E. Dunkle and Mary Catherine Dennis
28. Self-Management of Health Behavior in Geriatric Medicine, W. Jack Rejeski, Lawrence R. Brawley, and Mary E. Jung
29. Rehabilitation of the Older Adult, Cynthia J. Brown and Claire Peel
30. Pain Management, Bruce A. Ferrell and Susan I. Charette
31. Palliative Care, Audrey Chun and R. Sean Morrison
32. Legal Issues, Marshall B. Kapp
33. Spirituality, Timothy P. Daaleman
34. Ethical Issues in Geriatric Medicine, Jason H. T. Karlawish and Bryan D. James
Section D: Surgical Management
35. Perioperative Evaluation and Management, Preeti N. Malani, Peter V. Vaitkevicius, and Mark B. Orringer
36. Anesthesia for Elderly Patients, Jeffrey H. Silverstein and G. Alec Rooke
37. Surgical Outcomes, Emily Finlayson and John D. Birkmeyer
Section E: Nutrition
38. Nutrition and Aging, Dennis H. Sullivan and Larry E. Johnson
39. Weight and Age: Paradoxes and Conundrums, Tamara B. Harris
40. Malnutrition and Enteral/Parenteral Alimentation, Jeffrey I. Wallace
41. Disorders of Swallowing, JoAnne Robbins, Jacqueline Hind, and Steven Barczi
42. Oral Cavity, Jonathan A. Ship
Section F: Sensory Function
43. Assessment and Rehabilitation of Older Adults with Low Vision, Gale R. Watson
44. Age-Related Changes in the Auditory System, Su-Hua Sha, Andra E. Talaska, and Jochen Schacht
Section G: Gender and Sexuality
45. Sex and Gender Across the Human Life Span, William R. Hazzard
46. Menopause and Midlife Health Changes, MaryFran R. Sowers
47. Sexuality, Sexual Function, and the Aging Woman, Stacy Tessler Lindau
48. Gynecologic Disorders, Karen L. Miller and Tomas L. Griebling
49. Sexuality, Sexual Function, Androgen Therapy, and the Aging Male, J. Lisa Tenover
50. Benign Prostate Disorders, Catherine E. DuBeau
Part III: GERIATRIC SYMPTOMS
51. Aging and Hemeostatic Regulation, George A. Kuchel
52. Frailty, Linda P. Fried, Jeremy D. Walston, and Luigi Ferrucci
53. Delirium, Sharon K. Inouye, Michael A. Fearing, and Edward R. Marcantonio
54. Falls, Mary B. King
55. Sleep Disorders, Mairav Cohen-Zion and Sonia Ancoli-Israel
56. Dizziness, Aman Nanda and Richard W. Besdine
57. Syncope, Rose Anne Kenny
58. Pressure Ulcers, Barbara M. Bates-Jensen
59. Incontinence, Theodore M. Johnson, II, and Joseph G. Ouslander
60. Elder Mistreatment, Mark S. Lachs
Part IV: ORGAN SYSTEMS AND DISEASES
Section A: Human Brain
61. Cellular and Neurochemical Aspects of the Aging Human Brain, Mark P. Mattson
62. Cognitive Changes Associated with Normal and Pathological Aging, Suzanne Craft, Brenna Cholerton, and Mark Reger
63. Psychoactive Drug Therapy, Bruce G. Pollock, Todd P. Semla, and Christina E. Forsyth
64. Cerebrovascular Disease, Eric Edward Smith, Ferdinand Buonanno, Aneesh Bhim Singhal, and J. Philip Kistler
65. Dementia Including Alzheimer's Disease, Cynthia M. Carlson, Carey E. Gleason, Luigi Puglielli, and Sanjay Asthana
66. Parkinson's Disease and Related Disorders, Stanley Fahn
67. Other Neurodegenerative Disorders, Victor Valcour and Bruce Miller
68. Traumatic Brain Injury, Sterling C. Johnson
69. Epilepsy, Ilo E. Leppik
70. Late-Life Mood Disorders, Dan G. Blazer
71. Schizophrenia, Danielle I. Anderson and Peter V. Rabins
72. General Topics in Geriatric Psychiatry, Mustafa M. Husain, Shawn M. McClintock, Kip E. Queenan, Aaron Van Wright, and Rajbir Bakshi
73. Management of Agitation in Dementia, Marcella Pascualy, Eric Petrie, Lucy Y. Wang, Suzanne B. Murray, and Elaine Peskind
Section B: Cardiology
74. Effects of Aging on Cardiovascular Structure and Function, Dalane W. Kitzma and George Taffet
75. Aging and Atherosclerosis, Susan Cheng, Susan M. Bell, and Susan J. Zieman
76. Coronary Heart Disease, Eric D. Peterson and Shahyar M. Gharacholou
77. Valvular Heart Disease, Nikhila Deo and Niloo M. Edwards
78. Heart Failure, Michael W. Rich
79. Cardiac Arrhythmias, Ziao-Ke Liu, Arshad Jahangir, and Win-Kuang Shen
80. Peripheral Vascular Disease, Andrew W. Gardner, John D. Sorkin, and Azhar Afaq
81. Hypertension, Mark A. Supiano
Section C: Respiratory System
82. Aging of the Respiratory System, Paul L. Enright
83. Chronic Obstructive Pulmonary Disease, Sachin Yende, Anne B. Newman, and don Sin
84. Diffuse Parenchymal Lung Disease, Victor J. Thannickal and Galen B. Toews
Section D: Nephrology
85. Changes in Kidney Function, Jocelyn Wiggins and Sanjeevkumar R. Patel
86. Renal Disease, Lynn Schlanger, Jeff M. Sands, and James L. Bailey
87. End-Stage Renal Disease, Mark L. Unruh
88. Disorders of Fluid Balance, Myron Miller
Section E: Gastroentorology
89. Effect of Aging on Gastrointestinal Function, Karen E. Hall
90. Hepatic, Biliary, and Pancreatic Disease, Justin C. Rice, Courtney Barancin, Mark Benson, and Michael Lucey
91. Upper Gastrointestinal Disorders, Alberto Pilotto and Marilisa Franceschi
92. Common Large Intestinal Disorders, Leon S. Maratchi and David A. Greenwald
93. Constipation, Danielle Harari
Section F: Onology
94. Oncology and Aging: General Principles, Arati V. Rao and Harvey Jay Cohen
95. Breast Disease, Gretchen G. Kimmick and Hyman B. Muss
96. Prostate Cancer, Kenneth J. Pienta
97. Lung Cancer, Daniel Morgensztern, Ramaswamy Govindan, and Michael C. Perry
98. Gastrointestinal Malignancies, Nadine A. Jackson and Peter C. Enzinger
99. Intracranial Neoplasms, Noelle K. LoConte, Julie E. Chang, and H. Ian Robins
100. Skin Cancer, Mathew W. Ludgate, Timothy M. Johnson, and Timothy S. Wang
Section G: Hematology
101. Aging of the Hematopoietic System, Gurkamal S. Chatta and Daniel A. Lipschitz
102. Anemia, Paulo H.M. Chaves
103. White Cell Disorders, Heidi D. Klepin and Bayard L. Powell
104. Non-Hodgkin's and Hodgkin's Lymphomas and Myeloma, William Ershler and Dan L. Longo
105. Thrombosis, Martin O'Donnell, Jeffrey S. Ginsberg, adn Clive Kearon
106. Hemorrhagic Disorders, Julia A.M. Anderson and Agnes Y.Y. Lee
Section H: Endocrinology and Metabolism
107. Aging and the Endocrine System and Selected Endocrine Disorders, David A. Gruenewald and Alvin M. Matsumoto
108. Thyroid Diseases, Jerome M. Hershman, Sima Hassani, and Mary J. Samuels
109. Diabetes Mellitus, Annette M. Chang and Jeffrey B. Halter
110. Dyslipoproteinemia, Leslie I. Katzel, Jacob Blumenthal, John D. Sorkin, and Andrew P. Goldberg
111. Hyperparathyroidism and Paget's Disease of Bone, Kenneth W. Lyles
Section I: Mobility and Musculoskeletal System
112. Aging of the Muscles and Joints, Richard F. Loeser, Jr., and Osvaldo Delbono
113. Biomechanics of Mobility, James A. Ashton-Miller and Neil B. Alexander
114. Exercise: Physiologic and Functional Effects, Robert S. Schwartz and Wendy M. Kohrt
115. Mobility, Jennifer Brach, Caterina Rosano, and Stephanie Studenski
116. Osteoarthritis, Shari M. Lang and Yvette L. Ju
117. Osteoporosis, Gustavo Duque and Bruce R. Troen
118. Hip Fractures, Ram R. Miller, Colleen Christmas, and Jay Magaziner
119. Myopathy, Polymyalgia Rheumatics, and Temporal Arthritis, Yuri R. Nakasato and Bruce A. Carnes
120. Rheumatoid Arthritis and Other Autoimmune Diseases, Raymond Yung
121. Back Pain and Spinal Stenosis, Leo M. Cooney, Jr.
122. Primary Considerations in Managing the Older Patient with Foot Problems, Arthur E. Helfand
123. Fibromyalgia and Myofascial Pain Syndromes, Cheryl D. Bernstein and Debra K. Weiner
Section J: Infectious Diseases and Immunology
124. Infection in the Elderly, Kevin P. High
125. General Principles of Antimicrobial Selection, Maureen Bolon and Stephen G. Weber
126. Pneumonia, Thomas J. Marrie
127. Urinary Tract Infections, Lindsay E. Nicolle
128. Human Immunodeficiency Virus Infection, Amy C. Justice129. Herpes Zoster, Jack I. Twersky and Kenneth Schmader
130. Influenza and Respiratory Syncytial Virus, Mark B. Loeb
Index

Jeffrey B. Halter, MD

Professor of Internal Medicine

Chief, Division of Geriatric Medicine

Director, Geriatrics Center and Institute of Gerontology

University of Michigan

Ann Arbor, MI

Joseph G. Ouslander, MD

Professor and Associate Dean for Geriatric Programs

Charles E. Schmidt College of Biomedical Science

Professor (Courtesy), Christine E. Lyon College of Nursing

Florida Atlantic University

Professor of Medicine (Voluntary)

Division of Gerontology and Geriatric Medicine

University of Miami Miller School of Medicine

Boca Raton, FL

Mary E. Tinetti, MD

Gladys Phillips Crofoot Professor of Medicine, Epidemiology, and Public Health

Director, Program on Aging

Yale University School of Medicine

New Haven, CT

Stephanie Studenski, MD, MPH

Professor, Department of Medicine (Geriatrics)

University of Pittsburgh

Staff Physician, VA Pittsburgh GRECC

Pittsburgh, PA

Kevin P. High, MD, MS

Chief, Section on Infectious Diseases

Professor of Medicine, Sections on Infectious Diseases,

Hematology/Oncology, and Molecular Medicine

Wake Forest University Health Sciences

Winston-Salem, NC

Sanjay Asthana, MD

Duncan G. and Lottie H. Ballantine Chair in Geriatrics

Professor and Head, Section of Geriatrics & Gerontology

University of Wisconsin School of Medicine and Public Health

Director, Geriatric Research, Education and Clinical Center (GRECC)

William S. Middleton Memorial Veterans Hospital

Associate Director, Wisconsin Alzheimer's Institute

Madison, WI

EDITOR EMERITUS AND SENIOR ADVISOR:

William R. Hazzard, MD

Professor of Medicine

University of Washington

Director, Geriatrics and Extended Care

VA Puget Sound Health Care System

Seattle, WA

Senior Editorial Assistant:

Nancy Woolard, MD

Wake Forest University Health Sciences

Winston-Salem, NC