FRONTIERS IN AUTISM RESEARCH: New Horizons for Diagnosis and Treatment
This book focuses on the emerging and expanding areas of research on ASD and their potential to lead to better diagnosis and more effective therapies. These areas include innovative and integrative approaches to genetic/genomic analyses and investigations of epigenetic contributions, including the role of noncoding RNAs, DNA methylation, alternative splicing, RNA editing, and faulty translation in gene regulation and expression, metabolic and immune dysfunction, co-morbidities, as well as hormonal and gene-environment interactions that may increase risk for ASD.Within each chapter, experts review cutting-edge research as well as provide their perspective on the future of research in their respective areas, including the challenges involved and the types of studies or advances that are necessary to move the field forward to achieve predicted translational goals.Contributors: Argel Aguilar-Valles, Evdokia Anagnostou, Emma Ashwin, Bonnie Auyeung, Kelly M Bakulski, Simon Baron-Cohen, Margaret L Bauman, Donna Betts, Chad A Bousman, Daniel B Campbell, Manuel F Casanova, Bhismadev Chakrabarti, Gursharan Chana, Abha Chauhan, Ved Chauhan, Jessica DeWitt, Keith W Dunaway, Alal Eran, Ian P Everall, M Daniele Fallin, Richard E Frye, Piers Gillett, Matthew Ginsberg, Christos G Gkogkas, Rhonda J Greenhaw, Simon G Gregory, Elena L Grigorenko, Feng Gu, Rebecca Harmer, Martha Herbert, Valerie W Hu, Karen L Jones, Petra Kern, Arkady Khoutorsky, Rebecca Knickmeyer, Isaac S Kohane, Louis M Kunkel, Janine M LaSalle, Michael V Lombardo, Deepali Mankad, Marvin Natowicz, Laura Nicholls, Christos Pantelis, Natalia Rakhlin, Radhika Ramadas, Daniel A Rossignol, Tewarit Sarachana, Stephen W Scherer, Gabriela Schmulevich, Ayten Shah, Frank R Sharp, Alison B Singer, Efstratios Skafidas, Estate M Sokhadze, Nahum Sonenberg, Boryana Stamova, Zohreh Talebizadeh, Renee Testa, Judy Van de Water, Irina Voineagu, Daniel Williams, Ryan K C Yuen, Daniela Zantomio.
1133103278
FRONTIERS IN AUTISM RESEARCH: New Horizons for Diagnosis and Treatment
This book focuses on the emerging and expanding areas of research on ASD and their potential to lead to better diagnosis and more effective therapies. These areas include innovative and integrative approaches to genetic/genomic analyses and investigations of epigenetic contributions, including the role of noncoding RNAs, DNA methylation, alternative splicing, RNA editing, and faulty translation in gene regulation and expression, metabolic and immune dysfunction, co-morbidities, as well as hormonal and gene-environment interactions that may increase risk for ASD.Within each chapter, experts review cutting-edge research as well as provide their perspective on the future of research in their respective areas, including the challenges involved and the types of studies or advances that are necessary to move the field forward to achieve predicted translational goals.Contributors: Argel Aguilar-Valles, Evdokia Anagnostou, Emma Ashwin, Bonnie Auyeung, Kelly M Bakulski, Simon Baron-Cohen, Margaret L Bauman, Donna Betts, Chad A Bousman, Daniel B Campbell, Manuel F Casanova, Bhismadev Chakrabarti, Gursharan Chana, Abha Chauhan, Ved Chauhan, Jessica DeWitt, Keith W Dunaway, Alal Eran, Ian P Everall, M Daniele Fallin, Richard E Frye, Piers Gillett, Matthew Ginsberg, Christos G Gkogkas, Rhonda J Greenhaw, Simon G Gregory, Elena L Grigorenko, Feng Gu, Rebecca Harmer, Martha Herbert, Valerie W Hu, Karen L Jones, Petra Kern, Arkady Khoutorsky, Rebecca Knickmeyer, Isaac S Kohane, Louis M Kunkel, Janine M LaSalle, Michael V Lombardo, Deepali Mankad, Marvin Natowicz, Laura Nicholls, Christos Pantelis, Natalia Rakhlin, Radhika Ramadas, Daniel A Rossignol, Tewarit Sarachana, Stephen W Scherer, Gabriela Schmulevich, Ayten Shah, Frank R Sharp, Alison B Singer, Efstratios Skafidas, Estate M Sokhadze, Nahum Sonenberg, Boryana Stamova, Zohreh Talebizadeh, Renee Testa, Judy Van de Water, Irina Voineagu, Daniel Williams, Ryan K C Yuen, Daniela Zantomio.
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FRONTIERS IN AUTISM RESEARCH: New Horizons for Diagnosis and Treatment

FRONTIERS IN AUTISM RESEARCH: New Horizons for Diagnosis and Treatment

FRONTIERS IN AUTISM RESEARCH: New Horizons for Diagnosis and Treatment

FRONTIERS IN AUTISM RESEARCH: New Horizons for Diagnosis and Treatment

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Overview

This book focuses on the emerging and expanding areas of research on ASD and their potential to lead to better diagnosis and more effective therapies. These areas include innovative and integrative approaches to genetic/genomic analyses and investigations of epigenetic contributions, including the role of noncoding RNAs, DNA methylation, alternative splicing, RNA editing, and faulty translation in gene regulation and expression, metabolic and immune dysfunction, co-morbidities, as well as hormonal and gene-environment interactions that may increase risk for ASD.Within each chapter, experts review cutting-edge research as well as provide their perspective on the future of research in their respective areas, including the challenges involved and the types of studies or advances that are necessary to move the field forward to achieve predicted translational goals.Contributors: Argel Aguilar-Valles, Evdokia Anagnostou, Emma Ashwin, Bonnie Auyeung, Kelly M Bakulski, Simon Baron-Cohen, Margaret L Bauman, Donna Betts, Chad A Bousman, Daniel B Campbell, Manuel F Casanova, Bhismadev Chakrabarti, Gursharan Chana, Abha Chauhan, Ved Chauhan, Jessica DeWitt, Keith W Dunaway, Alal Eran, Ian P Everall, M Daniele Fallin, Richard E Frye, Piers Gillett, Matthew Ginsberg, Christos G Gkogkas, Rhonda J Greenhaw, Simon G Gregory, Elena L Grigorenko, Feng Gu, Rebecca Harmer, Martha Herbert, Valerie W Hu, Karen L Jones, Petra Kern, Arkady Khoutorsky, Rebecca Knickmeyer, Isaac S Kohane, Louis M Kunkel, Janine M LaSalle, Michael V Lombardo, Deepali Mankad, Marvin Natowicz, Laura Nicholls, Christos Pantelis, Natalia Rakhlin, Radhika Ramadas, Daniel A Rossignol, Tewarit Sarachana, Stephen W Scherer, Gabriela Schmulevich, Ayten Shah, Frank R Sharp, Alison B Singer, Efstratios Skafidas, Estate M Sokhadze, Nahum Sonenberg, Boryana Stamova, Zohreh Talebizadeh, Renee Testa, Judy Van de Water, Irina Voineagu, Daniel Williams, Ryan K C Yuen, Daniela Zantomio.

Product Details

ISBN-13: 9789814602174
Publisher: World Scientific Publishing Company, Incorporated
Publication date: 05/09/2014
Sold by: Barnes & Noble
Format: eBook
Pages: 724
File size: 5 MB

Table of Contents

Preface xi

About the Editor xv

List of Contributors xvii

Dissecting the Genetic Architecture of ASD 1

Chapter 1 Phenotype Definition A Cornerstone of Autism Research, Diagnosis and Therapy Valerie W. Hu 3

Chapter 2 From Molecular Pathways to ASD Therapy: Insights from Syndromic Forms of Autism Laura Nicholls Radhika Ramadas Irina Voineagu 23

Chapter 3 Language Impairment in Autism Spectrum Disorders Natalia Rakhlin Elena L. Grigorenko 47

Chapter 4 Whole Genome Sequencing in Autism: Clinical Translation Ryan K.C. Yuen Stephen W. Scherer 69

Chapter 5 The Impact of Integrative Unconventional Data Analysis Approaches on Advancing Autism Genetics Research Zohreh Talebizadeh Ayten Shah 99

Chapter 6 Construction of a Genetic Classifier for ASD Using Gene Pathway Analysis Gursharan Chana Renee Testa Piers Gillett Daniel Williams Chad A. Bousman Daniela Zantomio Ian P. Everall Christos Pantelis Efstratios Skafidas 119

Gene Dysregulation in ASD: From Transcription to Translation 145

Chapter 7 Genome-Wide Expression Studies of Blood and Lymphoblastoid Cell Lines in Autism Spectrum Disorders Boryana Stamova Frank R. Sharp 147

Chapter 8 Searching in the "Dark": Non-coding RNA as a New Avenue of Autism Research Tewarit Sarachana Valerie W. Hu 175

Chapter 9 Targeting Noncoding RNA for Treatment of Autism Spectrum Disorders Jessica DeWitt Daniel B. Campbell 203

Chapter 10 A-to-I RNA Editing in Autism Spectrum Disorder Alal Eran Isaac S. Kohane Louis M. Kunkel 229

Chapter 11 Translational Control of Autism and Fragile-X Syndrome Christos G. Gkogkas Argel Aguilar-Valles Arkady Khoutorsky Nahum Sonenberg 249

Epigenetic, Environmental, and Physiological Contributions to ASD 277

Chapter 12 Epigenetics in Autism Matthew Ginsberg Marvin Natowicz 279

Chapter 13 The Epigenetics of Autism ? Running Beyond the Bases Simon G. Gregory 303

Chapter 14 Genes and Environment in Autism Spectrum Disorders: An Integrated Perspective Kelly M. Bakulski Alison B. Singer M. Daniele Fallin 335

Chapter 15 The Potential Brain Drain from Environmental Exposures on the Methylome and Genome Across Generations Janine M. LaSalle Keith W. Dunaway 375

Chapter 16 Oxidative Stress and Mitochondrial Dysfunction in ASDs Feng Gu Ved Chauhan Abha Chauhan 407

Chapter 17 Maternal Autoantibodies in Autism Spectrum Disorder Karen L. Jones Judy Van de Water 429

Chapter 18 Why is Autism More Common in Males? Simon Baron-Cohen Michael V. Lornbardo Bonnie Auyeung Emma Ashwin Bhismadev Chakrabarti Rebecca Knickmeyer 451

Moving Towards Personalized Treatment of ASD and Lifespan Issues 471

Chapter 19 Future Directions in Psychopharmacology of Autism Spectrum Disorder Deepali Mankad Evdokia Anagnostou 473

Chapter 20 Medical Co-Morbidities in Autism: Clues to Underlying Biological Mechanisms and/or Diagnostic Subtypes? Margaret L. Bauman 497

Chapter 21 Translational Implications of a Whole-Body Approach to Brain Health in Autism: How Transduction between Metabolism and Electrophysiology Points to Mechanisms for Neuroplasticity Martha R. Herbert 515

Chapter 22 Achieving Optimal Outcomes in Autism: Treating Potentially Reversible Conditions Associated with Autism Spectrum Disorder Richard E. Frye Daniel A. Rossignol 557

Chapter 23 Transcranial Magnetic Stimulation: Application in Autism Treatment Manuel F. Casanova Estate M. Sokhadze 583

Chapter 24 Music Therapy: Personalized Interventions for Individuals with Autism Spectrum Disorder Petra Kern 607

Chapter 25 The Contributions of Art Therapy in Treatment, Assessment, and Research with People Who Have Autism Spectrum Disorders Donna Belts Rebecca Harmer Gabriela Schmulevich 627

Chapter 26 Shifting Paradigms: An Examination of Our Understanding of Adult Autism Rhonda J. Greenhaw 655

Index 683

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