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Detection Challenges in Clinical Diagnostics

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  • Anonymous

    Posted December 22, 2013

    The book "Detection Challenges in Clinical Diagnostics&qu

    The book "Detection Challenges in Clinical Diagnostics" edited by Vadgama & Peteu is the second volume in the "Detection Science" Series, edited by the Royal Society of Chemistry (RSC). Throughout this book, leading researchers from academia and clinical practitioners are bringing the reader up to date with the fast evolving technology. The focus is on the diagnostics needs and main bottlenecks or challenges when “dealing with the world of real biological measurement – especially from the perspective of a commonly neglected expert: the end user.”

    Following a logical progression, this book looks at the big picture of the clinical diagnostics both in laboratory and bedside, continues with the blood glucose sensors, followed by the disease diagnostics biomarkers and next dives into more challenges form the different case studies of: the implanted sensor long-term biocompatibility, the quantification of peroxynitrite as an important nitro-oxidative species, the correct classification of patients at risk for myelodysplastic syndrome, the early cancer diagnosis via fibre-optic Raman interrogation, and the complex signal handling with arrays.

    More specifically, the Chapter 1 (Thompson et al) and Chapter 2 (Vadgama et al) outline the Clinical Diagnostics, both in the laboratory and at the bedside. The progress and challenges of the blood glucose biosensors is illustrated in Chapter 3 (Wang and Hu). Chapter 4 (Gaspar et al) offers a critical overview of the recent progress and many challenges in electrochemical detection of disease-related diagnostic biomarkers. Chapter 5 (Meyerhoff et al) is focusing on the challenges of long-term biocompatibility for the implanted sensors. The case of more exotic, short-lived radical species such as peroxynitrite is featured in Chapter 6 (by Peteu and Szunerits) with the significant difficulties of measurement in vivo. The myelodysplastic syndromes is illustrated in Chapter 7 (by McNamara et al) with its major challenge: how to correctly classify and “risk stratify” the patients. Chapter 8 (by Barr et al) reports on Raman for non-invasive early cancer diagnosis with fibre-optic interrogation as an in situ potential surgical adjunct. Signal handling with arrays is well exemplified in Chapter 9 (by Kendall et al).

    I found this to be very good and quite a thought-provoking book, with each chapter offering a fresh view of the state of the art and related future challenges for the future of specific chemical sensors and clinical diagnostics.

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