This text offers the first comprehensive synthesis of the history of U.S.-Chinese relations from initial contact to the present. Balancing the modern (1784–1949) and contemporary (1949–) periods, Dong Wang tells the story of the interaction over the course of centuries between two of the world’s great powers from the perspective of both sides. The author explores key themes in each phase of the relationship and highlights important case studies for more in-depth treatment. She examines state-to-state diplomacy, as well as economic, social, military, religious, and cultural interplay within varying national and international contexts. In both form and content, these multi-faceted encounters have shaped one of the most significant bilateral relationships of our time. As China itself continue to grow in international importance, so does the U.S.–China relationship, and this book provides an essential grounding for understanding its past, present, and possible futures.