The $1,000 Genome: The Revolution in DNA Sequencing and the New Era of Personalized Medicine

Overview

Since the conclusion of the Human Genome Project in 2003, scientists have been racing towards a grand goal: offering individuals a decoding of their complete genetic makeup for just $1,000. As Kevin Davies reveals in this exquisitely reported account, the $1,000 genome will be a reality by 2011 and it will usher in a whole new era of personalized, genomic medicine. Capable of presenting much more advanced information than the current crop of cheek-swab services, the $1,000 complete genome raises some ...
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The $1,000 Genome: The Revolution in DNA Sequencing and the New Era of Personalized Medicine

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Overview

Since the conclusion of the Human Genome Project in 2003, scientists have been racing towards a grand goal: offering individuals a decoding of their complete genetic makeup for just $1,000. As Kevin Davies reveals in this exquisitely reported account, the $1,000 genome will be a reality by 2011 and it will usher in a whole new era of personalized, genomic medicine. Capable of presenting much more advanced information than the current crop of cheek-swab services, the $1,000 complete genome raises some extraordinary possibilities. We will be able to learn if we have genes that predispose us to a host of diseases, and to take a wide range of preventative measures. Drug companies may be able to create versions of drugs tailored specifically to our individual DNA. But we may also face the psychological burden of learning that we have the gene for an incurable disease, such as Parkinson’s.

Acclaimed author Kevin Davies introduces the pioneers of this medical revolution and probes deeply into both the medical benefits and ethical issues of personal genetic testing, also exploring the psychological complexities of learning one’s DNA results, based on both his own experience of being tested and that of a number of others. The $1,000 Genome is an indispensable guide to the new era of personalized medicine.

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Editorial Reviews

From the Publisher
"Johnny Heller reads with fluency and fluidly." —-Library Journal Audio Review
Matt Ridley
&'grave;The great impact of a new technology – from cotton underwear to the jet to the computer – comes not when it is invented, but when it becomes cheap enough to be within the reach of everybody. Gene sequencing has now reached that point. With unrivalled knowledge of the people who made this possible, Kevin Davies eloquently explains how it came about, and hints at what will come next.’’
Library Journal
How is it that less than a decade after the first human genome sequencing project was completed, anyone will shortly be able to purchase a personal genomic sequence for just $1000? Molecular biologist Davies (Cracking the Genome) discusses the path of human genomics from government project to commercial product, touching on ethical issues, medical uses, and the psychological implications of learning one's DNA results. The fascinating and clearly presented information is only slightly marred by frequent, unnecessary restatements of the text. Two-time Audie Award winner Johnny Heller reads with fluency and fluidly, even when faced with polysyllabic technical terms. For anyone interested in modern science, especially medical or ethical issues. ["An important overview," read the review of the Free Pr: S. & S. hc, LJ 9/1/10.—Ed.]—I. Pour-El, Des Moines Area Community Coll., Boone, IA
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Product Details

  • ISBN-13: 9781416569619
  • Publisher: Free Press
  • Publication date: 6/30/2015
  • Pages: 352

Meet the Author

Kevin Davies, Ph.D., is the author of The $1,000 Genome. His previous book Cracking the Genome was translated into 15 languages. He is currently Editor-in-Chief of Bio•IT World, a trade magazine covering the role of technology in the life sciences. He was the founding editor of Nature Genetics, the world's leading genetics journal, which he headed for its first five years. He has also written for the Times (London), Boston Globe, New England Journal of Medicine, and New Scientist, among others. His first book, Breakthrough (co-authored with Michael White) told the story of the race for the BRCA1 breast cancer gene. Davies holds an M.A. in biochemistry from the University of Oxford and a Ph.D in molecular genetics from the University of London. He held postdoctoral fellowships at MIT and Harvard Medical School before moving into science publishing as an editor with Nature magazine. He lives in Lexington, Massachusetts.
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Table of Contents

Introduction 1

Chapter 1 Jim and Craig's Excellent Adventure 15

Chapter 2 23 and You 30

Chapter 3 Everybody Wants to Change the World 54

Chapter 4 DNA Dreams 79

Chapter 5 The British Invasion 102

Chapter 6 Service Call 116

Chapter 7 My Genome and Me 137

Chapter 8 Consumer Reports 158

Chapter 9 Cease and Desist 180

Chapter 10 Another Week, Another Genome 206

Chapter 11 The 15-Minute Genome 231

Chapter 12 Personalized Response 248

Chapter 13 The Rest of Us 264

Notes 287

Acknowledgments 325

Index 327

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