20Th Century Microbe Hunters / Edition 1

20Th Century Microbe Hunters / Edition 1

by Robert I Krasner

binding type PBSee more details below


binding type PB

Product Details

Jones & Bartlett Learning
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0.46(w) x 6.00(h) x 9.00(d)

Table of Contents

Preface xiii

Chapter 1 Chagas Disease-A Kiss of Death Carlos Chagas 1

Microbe Hunter Carlos Justiniano Ribeiro Chagas 1

The Life Cycle of T. Cruzi and Direct Transmission of Chagas Disease 4

Cycle of Chagas Disease 6

Indirect Transmission of Chagas Disease 8

Pathology and Epidemiology 9

Treatment and Prevention of Chagas Disease 11

Progress in the Fight Against Chagas Disease 12

The Legacy of Carlos Chagas 13

Chapter 2 The Mold That Changed the World Alexander Fleming 15

A Brief History of Antimicrobials 16

Microbe Hunter Alexander Fleming 17

The Discovery of Penicillin 21

Florey and Chain: The Development of Penicillin 22

Microbes and War 25

Scaling Up Penicillin Production 26

Controversy Over Therapeutic Significance 28

The Legacy of Alexander Fleming 29

Chapter 3 The Cause and Transmission of Epidemic Typhus Fever Charles Nicolle 35

Rickettsia: An Oddball Group of Bacteria 37

The Human Body Louse: Vector of Epidemic Typhus Fever 38

Microbe Hunter Charles Nicolle 39

The Pathology of Epidemic Typhus Fever 42

A History of Human Misery 43

Epidemic Typhus Today 46

The Legacy of Charles Nicolle 47

Chapter 4 Discovery of the Influenza Virus Richard E. Shope 49

Microbe Hunter Richard Edwin Shope 50

Viruses as the Cause of Swine Influenza 51

Viruses as the Cause of Human Influenza 52

Connecting the 1918 Human and Swine Influenza Viruses 53

The Nature of the Influenza Virus 55

Antigenic Shift and Antigenic Drift 57

Influenza Transmission and Epidemiology 58

The Influenza Vaccine 59

1918: The Mother of All Pandemics 61

The Mystery of the 1918 Influenza Pandemic 67

Avian Influenza 67

The Legacy of RichardEdwin Shope 68

Chapter 5 Development of the First Polio Vaccine Jonas Salk 69

Polio in History 70

Polio: The Virus and the Disease 71

Societal Effects of Polio 72

Microbe Hunter Jonas Salk 75

Inactivated Versus Live Attenuated Polio Vaccines 77

Polio on the Road to Eradication 81

The Legacy of Jonas Salk 83

Postscript: Author's Visit With Peter Salk 86

Chapter 6 Eradication of Smallpox Donald A. Henderson 89

Microbe Hunter Donald A. Henderson 91

The Nature of the Smallpox Virus 93

Transmission and Pathology of Smallpox 94

Smallpox in History 97

Smallpox Vaccination Edward Jenner 98

The Eradication of Smallpox 102

Smallpox as a Biological Weapon 106

The Legacy of Donald A. Henderson 109

Postscript: Personal Reflections of Donald A. Henderson 110

Chapter 7 Prions-All But the Moo D. Carleton Gajdusek Stanley Prusiner 111

History and Nature of Transmissible Spongiform Encephalopathies 113

Microbe Hunter D. Carleton Gajdusek 115

Microbe Hunter Stanley Prusiner 122

Mad Cow Disease and Variant Creutzfeldt-Jakob Disease 126

The Species Leap 127

Countering Mad Cow Disease 130

How Safe Are We? 133

The Legacy of D. Carleton Gadjusek Stanley Prusiner 134

Chapter 8 Acquired Immunodeficiency Syndrome-A 20th Century Ongoing Plague Robert C. Gallo Luc Montagnier 137

The History of AIDS 138

The Societal Impact of AIDS 140

Discovery of the Human Immunodeficiency Virus 142

Microbe Hunter Robert C. Gallo 143

Microbe Hunter Luc Montagnier 145

The Controversy Over the Discovery of HIV 147

Replication of HIV 148

Pathology of AIDS 151

Origin and Spread of HIV/AIDS 152

Transmission of HIV 153

Does HIV Really Cause AIDS? 155

Treatment of HIV/AIDS and the Search for a Vaccine 156

The Legacy of Robert Gallo Luc Montagnier 160

Postscript: Author's Visit With Luc Montagnier 160

Chapter 9 Ulcers-A Bacterial Infection Barry Marshall J. Robin Warren 163

Microbe Hunters J. Robin Warren Barry Marshall and the Discovery of Helicobacter pylori 167

Pathology of Ulcers 170

Biology of Helicobacter pylori 173

The Legacy of J. Robin Warren Barry Marshall 176

Chapter 10 Eradication of Guinea Worm Disease Donald R. Hopkins 179

Microbe Hunter Donald R. Hopkins 180

Biology of Dracunculus medinensis 182

Working to Eradicate Guinea Worm Disease 186

Breaking the Cycle of Transmission 192

The Legacy of Donald R. Hopkins 196

Postscript: Author's Visit with Dr. Hopkins 197

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