3-D Conformal Radiotherapy: A New Era in the Irradiation of Cancer

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Computer applications in radiotherapy have multiplied enormously over the past three decades. This guidebook explores critical issues in the design and delivery of computerized radiotherapy, including CT simulation, CT/MRI integration, 3-D treatment planning, plan optimization, on-line portal imaging, multileaf collimation, dose intensity modulation and computerized treatment delivery. A comprehensive overview of these techniques is presented by an outstanding faculty. Contributors discuss the latest developments...

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Overview

Computer applications in radiotherapy have multiplied enormously over the past three decades. This guidebook explores critical issues in the design and delivery of computerized radiotherapy, including CT simulation, CT/MRI integration, 3-D treatment planning, plan optimization, on-line portal imaging, multileaf collimation, dose intensity modulation and computerized treatment delivery. A comprehensive overview of these techniques is presented by an outstanding faculty. Contributors discuss the latest developments in clinical treatment with irradiation, for brain, head and neck, lung, gastrointestinal, prostate and other major cancer sites. This practical and clinically-oriented volume is especially intended for radiotherapy clinical and technical practitioners - physicans, physicists, radiation technology therapists, and dosimetrists - as well as for all oncologists interested in recent major advances in radiation oncology.

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Product Details

Table of Contents

Preface
3-D Radiation Treatment Planning: A New Era 1
Assessment of the Impact of Local Control on Clinical Outcome 17
Defining Our Goals: Volume and Dose Specification for 3-D Conformal Radiation Therapy 24
Imaging: The Basis for Effective Therapy 31
The CT-Simulation 3-D Treatment Planning Process 43
Clinical Interpretation of Dose-Volume Histograms: The Basis for Normal Tissue Preservation and Tumor Dose Escalation 57
Quantitative Plan Evaluation: TCP/NTCP Models 67
Objective Plan Evaluation Using a Score Function Tool 81
Optimization of 3-D Conformal Radiation Treatment Plans 86
Quality Assurance in 3-D Treatment Planning 104
Patient Positioning Devices: Innovations for Set-Up Precision, Speed, and Patient Comfort 115
Computer-Controlled Radiation Therapy and Multileaf Collimation 123
3-D Conformal Therapy Using Beam Intensity Modulation 139
On-Line Portal Imaging: Contributions and Limitations in Clinical Practice 156
Radiation Oncology Picture Archiving and Communications System: The Electronic Viewbox 168
Tissue Inhomogeneity in the Thorax: Implications for 3-D Treatment Planning 180
3-D Conformal Radiotherapy for Lung Cancer. The Washington University Experience 188
3-D Conformal Radiation Therapy for Non-Small Cell Lung Carcinoma. Clinical Experience at the Memorial Sloan-Kettering Cancer Center 199
3-D Conformal Radiotherapy in Head and Neck Cancer. The Washington University Experience 207
3-D Conformal Radiation Therapy in Upper Gastrointestinal Cancer. The University of Michigan Experience 221
3-D Conformal Radiotherapy for Carcinoma of the Prostate. Clinical Experience at the Memorial Sloan-Kettering Cancer Center 229
3-D Conformal Radiotherapy for Prostate Cancer. The University of Michigan Experience 238
3-D Treatment Planning for Brain Tumors 244
3-D Conformal Radiotherapy for Brain Tumors. The University of Michigan Experience 250
Multi-Institutional Clinical Trials: 3-D Conformal Radiotherapy Quality Assurance. Guidelines in an NCI/RTOG Study Evaluating Dose Escalation in Prostate Cancer Radiotherapy 255
Where Will 3-D Conformal Radiation Therapy Be at the End of the Decade? 261
Subject Index 273
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