5-Ht3 Antagonists; 5-Ht3 Antagonist, Ondansetron, Alosetron, Dazopride, Cilansetron, Granisetron, Tropisetron, Bemesetron, Zacopride

Overview

Purchase includes free access to book updates online and a free trial membership in the publisher's book club where you can select from more than a million books without charge. Chapters: 5-Ht3 Antagonist, Ondansetron, Alosetron, Dazopride, Cilansetron, Granisetron, Tropisetron, Bemesetron, Zacopride, Renzapride, Dolasetron, Zatosetron, Palonosetron, Ramosetron, As-8112, Lerisetron, Batanopride, Lurosetron, Azasetron. Excerpt: Skeletal formula of ondansetron , the prototypical 5-HT3 antagonist The 5-HT3 ...

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Overview

Purchase includes free access to book updates online and a free trial membership in the publisher's book club where you can select from more than a million books without charge. Chapters: 5-Ht3 Antagonist, Ondansetron, Alosetron, Dazopride, Cilansetron, Granisetron, Tropisetron, Bemesetron, Zacopride, Renzapride, Dolasetron, Zatosetron, Palonosetron, Ramosetron, As-8112, Lerisetron, Batanopride, Lurosetron, Azasetron. Excerpt: Skeletal formula of ondansetron , the prototypical 5-HT3 antagonist The 5-HT3 antagonists are a class of medications that act as receptor antagonists at the 5-hydroxytryptamine-3 receptor (5-HT3 receptor), a subtype of serotonin receptor found in terminals of the vagus nerve and in certain areas of the brain . With the notable exception of alosetron and cilansetron , which are used in the treatment of irritable bowel syndrome , all 5-HT3 antagonists are antiemetics , used in the prevention and treatment of nausea and vomiting . They are particularly effective in controlling the nausea and vomiting produced by cancer chemotherapy and are considered the gold standard for this purpose. The 5-HT3 antagonists may be identified by the suffix setron , and are classified under code A04AA of the WHO 's Anatomical Therapeutic Chemical Classification System . History The history of the 5-HT3 receptor antagonists began in 1957, when J.H. Gaddum and Zuleika P. Picarelli at the University of Edinburgh proposed the existence of two serotonin receptor subtypes, the M and D receptors (thus named because their function could be blocked by morphine and Dibenzyline respectively), in a landmark paper. The 5-HT3 receptor was later found to correspond to the M receptor. In the 1970s, John Fozard proved that metoclopramide and cocaine were weak antagonists at the 5-HT3 (5-HT-M) receptor. Fozard and Maurice Gittos later synthesized MDL 72222, the first potent and truly selective 5-HT3 receptor antagonist. The antiemetic effects of metoclopramide where found to be ...

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Product Details

  • ISBN-13: 9781155149622
  • Publisher: General Books LLC
  • Publication date: 4/30/2010
  • Pages: 74
  • Product dimensions: 9.00 (w) x 6.00 (h) x 0.18 (d)

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