Post-Genomic Cardiology

by José Marín-García

Overview

Recent advances in molecular and cellular biology have markedly changed our understanding of the heart. In the post-genomic era, molecular medicine provides the clinician with a large collection of resources of effective techniques to improve diagnostic and therapeutic options and offers significant insights into the pathophysiology and etiology of an array of cardiovascular diseases. Post-Genomic Cardiology presents the first comprehensive and critical evaluation the field of cardiovascular molecular medicine. Notably, this book will provide the reader with sense of new directions in which molecular medicine may be applied.

A detailed primer presented in the beginning of the book outlines recent molecular, genetic, and cellular techniques. This is aimed at a broad audience that includes not only internists and clinical cardiologists, but also the medical school student, and the graduate/undergraduate student with limited knowledge of this molecular information. This is followed by critical and comprehensive discussions on the use of molecular, genetic, and cellular techniques used to identify the etiology and pathophysiology of specific cardiac diseases, as well as the diagnostic and therapeutic options available for infants, children, adults, and the aging population.

Key Features: Includes up-to-date discussions on aging and pediatric cardiology from a molecular perspective. Explains cutting-edge molecular techniques, including analysis of mitochondria and their role in cardiac dysfunction, and analysis of cardioprotection and metabolic syndrome. Surveys important cardiac abnormalities, such as, myocarditis and endocarditis. Discusses relevant genes, pathways, and expressionpatterns involved in each cardiovascular disease. Presents recent translational studies for the treatment of cardiovascular diseases including gene therapy, pharmacological treatments, and stem cell transplantation.

Product Details

ISBN-13:	9780124046429
Publisher:	Elsevier Science & Technology Books
Publication date:	05/09/2014
Sold by:	Barnes & Noble
Format:	eBook
Pages:	944
File size:	26 MB
Note:	This product may take a few minutes to download.

About the Author

Dr.José Marín-García, highly respected cardiologist, is the current Director of Molecular Cardiology and Neuromuscular Institute in Highland Park, NJ. He has 189 listed publications and an H-index of 30. He has written and edited Mitochondria and the heart (2005), Aging and the Heart (2008), Signaling in the Heart (2008). Heart Failure (2010), Post-Genomic Cardiology (2007), and Mitochondria and Their Role in Cardiovascular Disease (2012).

Table of Contents

Section I: Post-Genomic Cardiology 1. Introduction to the Molecular Biology of the Cell2. Methodologies in the Era of Cardiovascular "Omics 3. Post-Genomics Cardiovascular Signaling Pathways Section II: Pediatric Cardiology in the Post-Genomic Era 4. Molecular Determinants of Cardiac Development 5. Molecular Determinants of Congenital Heart Disease Section III: Post-Genomic Assessment of Coronary Artery Disease, Angiogenesis, and Hypertension 6. Molecular Determinants of Atherosclerosis7. Molecular Genetics of Coronary Artery Disease and Myocardial Infarction 8. Cellular and Molecular Aspects of Cardioprotection 9. Molecular Determinants of Cardiac Neovascularization 10. Post-Genomics Appraisal of Systemic and Pulmonary Hypertension Section IV: Post-Genomic Analysis of the Myocardium 11. Post-Genomic Appraisal of Myocarditis 12. Cardiomyopathies: A Comparative Analysis of Phenotypes and Genotypes Section V: Heart Failure, Cell Death, and Mitochondria Dynamics 13. Gene Profiling, Energy Metabolism, and Remodeling of the Failing Heart14. Oxidative Stress and Cell Death in Cardiovascular Disease: A Post-Genomic Appraisal 15. The Emerging Role of Mitochondrial Dynamics in Cardiovascular Disease Section VI: Molecular and Genetic Analysis of Metabolic Disorders 16. Post-Genomic Analysis of Fatty Acid and Glucose Metabolism in Cardiovascular Disease Section VII: Molecular Genetics of Dysrhythmias 17. Post-Genomic Analysis of Dysrhythmias and Sudden Death Section VIII: Genes, Gender, and Epigenetics 18. Gender and Cardiovascular Disease in the Post-Genomic Era Section IX: Aging and the Cardiovascular System 19. The Aging Heart: A Post-Genomic Appraisal 20. Targeted Strategies to Fight Cardiac Aging21. Aging and the Cardiovascular System: The Road Ahead Section X: Genetics, Epigenetics, and New Approaches to Treatment 22. Epigenetics and Cardiovascular Disease23. Gene- and Cell-Based Therapy for Cardiovascular Disease Section XI: Looking to the Future24. The Path to Personalized Cardiovascular Medicine

What People are Saying About This

From the Publisher

A comprehensive and critical evaluation of the multiple roles that molecular medicine plays in cardiology, aiding researchers and physicians addressing the genetic etiology and therapy of CVD

Editorial Reviews

"This Second edition of Post-Genomic Cardiology (PCG) deals with what promises to be the cardiology of the future. As the role of genetic screening in cardiology is strengthened, and as research on the multiple signaling pathways involved in cardiac organogenesis and pathology progresses, this 2nd edition of PCG further attempts to integrate known facts with what is still developing and with what is slowly becoming known. New areas of interest to cardiologists and researchers include systems biology, the constructive cycle of computational model building, and experimental verification. These are capable of providing the input necessary for exciting new discoveries, including the management of diseases in a “personalized” way. The book is fascinating because it introduces a field that no one with a minimum amount of scientific interest will be able to avoid in the very near future. Extensively referenced, and thoroughly researched, this book presents well-written and organized chapters, each with a summary of the important points discussed, followed by exhaustive bibliographies. A detailed glossary clearly defines the many acronyms used throughout the book. Unquestionably, this volume will be of great interest and use to clinical and research cardiologists, pharmacologists and genetics investigators; and to students of basic sciences. Dr. Marin-Garcia - author and editor of this 2nd edition of PGC has done an outstanding job of completing this challenging task." —Dr. Daniel Shindler

"This is a great book." —Dr. A. Bayes de Luna

From the Publisher