A Network-Based Approach to Cell Metabolism: From Structure to Flux Balances

by Oriol Güell

Overview

This thesis uses a systems-level approach to study the cellular metabolism, unveiling new mechanisms and responses that were impossible to reach with traditional reductionists procedures.

The results reported here have a potential application in areas like metabolic engineering and disease treatment. They could also be used in determining the accuracy of the gene essentiality of new genome-scale reconstructions.

Different methods and techniques, within the contexts of Systems Biology and the field known as Complex Networks Analysis have been applied in this work to show different features of the robustness of metabolic networks. The specific issues addressed here range from pure topological aspec

ts of the networks themselves to the balance of biochemical fluxes.

Product Details

ISBN-13:	9783319639994
Publisher:	Springer International Publishing
Publication date:	08/17/2017
Series:	Springer Theses
Edition description:	1st ed. 2017
Pages:	151
Product dimensions:	6.10(w) x 9.25(h) x (d)

About the Author

Oriol Güell holds a Ph.D. in Physical Chemistry from the University of Barcelona, Spain, and has broad experience in the theoretical modelling and the experimental applications of magnetic colloidal dispersions and in the computer modelling of metabolic networks. Currently, his main research focuses on obtaining and applying bio-based polymers and plasticisers and studying their associated physicochemical properties.

Table of Contents

Cellular Metabolism at the Systems Level.- Methods and Data.- Structural Knockout Cascades in Metabolic Networks.- Effects of Reaction Knockouts on Steady States of Metabolism.- Detection of Evolution and Adaptation Fingerprints in Metabolic Networks.- Assessing FBA Optimal States in the Feasible Flux Phenotypic Space.- Conclusions.