A Pharmacology Primer: Theory, Application and Methods

Overview

Designed for scientists who need to know the basics, A Pharmacology Primer provides a complete overview -- from the study of dose-response relationships and interpretation of tissue responses to the mechanisms by which drugs can elicit and inhibit cellular function. Terry Kenakin has drawn on his valuable experience as a research pharmacologist to put together this indispensable resource on the theories, principles, and applications of pharmacology.

Each well-organized chapter ...

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2004 Trade paperback BRAND NEW(NEVER OPENED)! ! -No international shipping available[GL3] Trade paperback (US). Glued binding. 214 p. Contains: Illustrations. Audience: ... General/trade. Read more Show Less

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Overview

Designed for scientists who need to know the basics, A Pharmacology Primer provides a complete overview -- from the study of dose-response relationships and interpretation of tissue responses to the mechanisms by which drugs can elicit and inhibit cellular function. Terry Kenakin has drawn on his valuable experience as a research pharmacologist to put together this indispensable resource on the theories, principles, and applications of pharmacology.

Each well-organized chapter guides readers through levels of increasing detail -- beginning with general concepts before moving on to methods used to estimate drug parameters, and then finishing with quantitative derivations of models and methods.

Important topics include: Drug Receptor Theory; Drug Antagonism; The Drug Discovery Process; Pharmacological Assay Formats; Interpretation of Drug Phenotypical Behavior; and Statistics & Experimental Design.

A Pharmacology Primer is stocked with helpful tools that insure a broad level of comprehension:

Key Features:

• Derivations of all formulae in every chapter
• Step-by-step guides for the standard methods of measuring drug activity
• Scores of full-color illustrations
• Bulleted lists of each section's key points
• Comprehensive glossary of pharmacological terms

Audience: Biochemists, molecular biologists, chemists, pharmacologists.

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Editorial Reviews

Doody's Review Service
Reviewer: Gregory Reed, PhD (University of Kansas Medical Center)
Description: Kenakin pulls the chemist and the biologist towards the intersection of their disciplines, showing how complex biological systems and their responses to chemicals may be described using data from appropriate experimental approaches in conceptual and mathematical models.
Purpose: The author notes that the genotype is one of the factors defining the effects of chemicals on biological systems (pharmacology), but that these end effects (phenotype)are the result of additional factors and events beyond the genotype. He focuses on the fundamental concepts of dose-response and signal processing as more proximal factors in drug effects. The appreciation of these functional factors is essential to the understanding of drug effects and to the process of rational drug development.
Audience: The book seeks to unite chemists, biologists, and pharmacologists for the understanding and experimental study of receptor pharmacology. The level of presentation is appropriate for those who are advanced graduate students and beyond.
Features: The design of each chapter is noteworthy— definitions and concepts are introduced and developed, with the increasing mathematical input necessary to support the development. For those wishing a more rigorous mathematical treatment, more extensive derivations are provided as an appendix to each chapter. This separation provides the level of mathematics required for basic understanding, but without intimidating the more mathematically-averse readers.
Assessment: The book seems to work quite well from the perspective of applying fundamental concepts of chemical kinetics to complex biological systems, and thus facilitating the recruitment of chemists into pharmacology. I cannot judge how well it will function in bringing biologists into pharmacology.

4 Stars! from Doody
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Product Details

  • ISBN-13: 9780124041615
  • Publisher: Elsevier Science & Technology Books
  • Publication date: 11/28/2003
  • Edition description: Older Edition
  • Pages: 336
  • Product dimensions: 8.50 (w) x 10.90 (h) x 0.40 (d)

Read an Excerpt

A primer for professionals in industry and research who need to know the basics of pharmacology
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Table of Contents

Foreword
1 What Is Pharmacology? 1
2 How Different Tissues Process Drug Response 17
3 Drug Receptor Theory 37
4 Pharmacological Assay Formats: Binding 53
5 Agonists: The Measurement of Affinity and Efficacy in Functional Assays 73
6 Drug Antagonism 93
7 The Drug Discovery Process: System-Independent Scales of Drug Activity 123
8 Statistics and Experimental Design 147
9 Selected Pharmacological Methods 177
Glossary of Pharmacological Terms 195
Appendices 201
Index 211
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