A Statistical Approach to Genetic Epidemiology: Concepts and Applications / Edition 2

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This is the second edition of the successful textbook written by the prize-winning scientist Andreas Ziegler, former President of the German Chapter of the International Biometric Society, and Inke K?nig, who has been teaching the subject over many years.
The book gives a comprehensive introduction into the relevant statistical methods in genetic epidemiology. The second edition is thoroughly revised, partly rewritten and includes now chapters on segregation analysis, twin studies and estimation of heritability. The book is ideally suited for advanced students in epidemiology, genetics, statistics, bioinformatics and biomathematics. Like in the first edition the book contains many problems and solutions.
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Editorial Reviews

From the Publisher
"This contribution fills a gap with a good selection of topics presented in a concise format that will be useful for biostatisticians starting in the field and geneticists or epidemiologists that want to master the specialized statistics used in genetics." (ISCB News, December 2008)

"…databases on genetic variation…are especially useful…the copious references and end-of-chapter links provide tools for readers and instructors to keep up with current developments." (The Quarterly Review of Biology, December 2006)

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Product Details

  • ISBN-13: 9783527324538
  • Publisher: Wiley, John & Sons, Incorporated
  • Publication date: 5/24/2010
  • Edition description: New Edition
  • Edition number: 2
  • Pages: 522
  • Product dimensions: 6.80 (w) x 9.60 (h) x 1.20 (d)

Meet the Author

After studying statistics and mathematics at the University of Munich and obtaining his doctoral degree from the University of Dortmund, Andreas Ziegler received the Johann-Peter-S??milch-Medal of the German Association for Medical Informatics, Biometry and Epidemiology for his post-doctoral work on "Model Free Linkage Analysis of Quantitative Traits" in 1999. In 2004, he was one of the recipients of the Fritz-Linder-Forum-Award from the German Association for Surgery. Andreas Ziegler is head of the Institute for Medical Biometry and Statistics at the University Clinic Schleswig-Holstein in L?beck, an acknowledged center of excellence for genetic epidemiological methods. Currently he is President of the German Region of the International Biometric Society.

Inke R. K?nig studied psychology at the universities of Marburg (Germany) as a scholar of the German National Academic Foundation and Dundee (Scotland) with a grant from the German Academic Exchange Service (DAAD). She has done research work at the Institute of Medical Biometry and Epidemiology in Marburg and since 2001 at the Institute of Medical Biometry and Statistics in L?beck. In 2004, she became vice director of the latter and also received the Fritz-Linder-Forum-Award from the German Association for Surgery. Besides holding the certificate "Biometrics in Medicine", she has collected teaching experience since 1998 as a lecturer for biomathematics, behavioural genetics, clinical epidemiology, genetic epidemiology, and evidence-based medicine.

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Table of Contents

Molecular Genetics
Formal Genetics
Genetic Markers
Data Quality
Genetic Map Distances
Model Based Linkage Analysis
Model Free Linkage Analysis for Binary Traits
Model Free Linkage Analysis for Quantitative Traits
Family Studies not Involving Genetic Markers
Fundamental Concepts of Association Analyses
Association Analysis with Unrelated Individuals
Family Based Association Analysis


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