Abnormal Cortical Development and Epilepsy / Edition 1

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Thanks to advanced imaging techniques, it is now possible to recognize 'in vivo' structural alterations of the cortex leading in many patien ts to epileptic syndromes, frequently resistent to pharmacological tre atment. In order to face this problem this book brings together specia lists who have contributed in the last few years to the study of norma l and pathological development, and on the basic and clinical issues r elated with cortical development and epilepsy. Areas analysed in this book are: mechanisms of cortical development; animal models of neurona l migration disorders mimicking human pathology; electroclinical, neur oradiological and neuropathological studies of the different forms of cortical dysplasia. Further discussions include the genetic aspects an d neurosurgical strategies for epilepsies secondary to cortical dyspla sia.

The book contains predominantly black-and-white illustrations, with some color illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: Carol Macmillan, MD, FRCP (C)(University of Illinois at Chicago College of Medicine)
Description: This book provides the proceedings of the seventh of a series of Pediatric Neurology meetings sponsored by the Italian-based Mariani Foundation. A series editor ensures continuity between publications and this volume has its own three editors.
Purpose: This book is intended to underscore the interaction between clinical and basic sciences methodologies in order to optimize patient care and to deepen knowledge of the neurobiology of cerebral dysplasia. That a wide knowledge base in understanding cerebral dysplasia is of major importance does not need to be underscored; the book addresses this issue exhaustively.
Audience: The multiple authors, many of whom are recognized authorities in their respective fields, target this book to basic and clinical neuroscientists. It would be most relevant to adult and pediatric neurologists, especially epileptologists, and to basic scientists working in the field of cerebral dysplasia.
Features: The book presents a contemporary statement of what is known about the neurobiology, epileptology, neuroimaging, neuropathology, and neurogenetics of cerebral dysplasia in six parts. Available animal models are discussed, and surgical approaches to seizure management are discussed. Dr. Dobyns' chapter on the genetic basis of malformations of neuronal migration is especially exciting, and the reproduction of MRI films and multiple well-chosen gross and light microscopy figures are outstanding. The use of some color plates would have added to the visual impact of the book.
Assessment: This is a book of excellent quality that fills a unique niche. It is very thorough but nonetheless readable, and would be a helpful addition to the teaching libraries of neurology, child neurology, and epilepsy programs.

4 Stars! from Doody
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Product Details

  • ISBN-13: 9780861965793
  • Publisher: Libbey, John & Company, Limited
  • Publication date: 1/1/1999
  • Edition number: 1
  • Pages: 324

Table of Contents

Synopsis: Epilepsies and cerebral dysplasia
Pt. I Introduction
Ch. 1 The cortical dysplasias and epilepsy: where have we been, where are we and where are we going? 3
Pt. II Cortical development
Ch. 2 The pioneering studies on neuronal migration in the developing cerebral cortex 23
Ch. 3 Acquired neonatal encephalopathies: cortical vasculature, postinjury reorganization, and neurological sequelae 35
Ch. 4 Some principles in the organisation and development of cortical connections 55
Ch. 5 Maturation of cortical physiological properties relevant to epileptogenesis 63
Ch. 6 Mechanisms of corticogenesis: cell proliferation and death in the developing human central nervous system 77
Ch. 7 Preferential impairment of motor and somatosensory cortices in two murine models of human diseases: the ethanol-exposed rat and the dystrophic mdx mouse 91
Pt. III Animal models
Ch. 8 The methylazoxymethanol MAM treated rat as an animal model for human development brain dysgeneses: morphological features 109
Ch. 9 The methylazoxymethanol MAM treated rat as an animal model for the neuronal migration disorders: electrophysiological findings in identified pyramidal neurones 121
Ch. 10 Epileptogenesis in the freeze model of cortical microgyria 133
Ch. 11 Neuronal development in an epileptic rat with cortical heterotopia 145
Pt. IV Electroclinical, imaging and neuropathological studies
Ch. 12 Neuroradiology of malformations of cortical development: band heterotopia, hemimegalencephaly, and polymicrogyria 161
Ch. 13 Neuroradiology of malformations of cortical development: schizencephaly, periventricular heterotopia 171
Ch. 14 Neuronal migration disorders and epilepsy in infancy 177
Ch. 15 Schizencephaly: clinical and genetic findings in a case series 181
Ch. 16 Polymicrogyria and epilepsy 191
Ch. 17 Periventricular nodular heterotopia: further delineation of the clinical syndromes 203
Ch. 18 The clinical and pathophysiological relevance of evoked potentials study in neuronal migration disorders 219
Ch. 19 Surgical pathology of cortical dysplasia, tuberous sclerosis and dysembryoplastic neuroepithelial tumours: experience with 55 cases in a recent series of 230 patients with chronic epilepsy 227
Ch. 20 Immunocytochemical studies in epileptogenic dysplastic tissue 241
Pt. V Genetic studies in neuronal migration disorders
Ch. 21 The role of homeobox genes in NMDs 253
Ch. 22 The genetic basis of malformations of neuronal migration: molecular mechanisms and clinical correlation 261
Pt. VI Surgical approaches - how, why, when?
Ch. 23 Surgical treatment of cortical dysplasias and migration disorders 275
Ch. 24 Surgical management of severe partial epilepsy symptomatic of neuronal migration disorders: physiopathological considerations and perspectives of research 303
Index 319
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