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Accurate Results in the Clinical Laboratory: A Guide to Error Detection and Correction

Overview

This practical, easy-to-use guide, named to Doody’s Core Titles 2013, addresses interference issues in all laboratory tests, including patient epigenetics, process of specimen collection, enzymes, biomarkers. Clinicians and laboratory scientists can therefore rely on one reference which speaks to both their needs of accurate specimen analysis and optimal patient care.

Erroneous hospital and pathology laboratory results can be confusing and problematic, especially in acute care ...

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Accurate Results in the Clinical Laboratory: A Guide to Error Detection and Correction

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Overview

This practical, easy-to-use guide, named to Doody’s Core Titles 2013, addresses interference issues in all laboratory tests, including patient epigenetics, process of specimen collection, enzymes, biomarkers. Clinicians and laboratory scientists can therefore rely on one reference which speaks to both their needs of accurate specimen analysis and optimal patient care.

Erroneous hospital and pathology laboratory results can be confusing and problematic, especially in acute care situations. While some factors creating interference, can be identified in the laboratory, detecting many others is often dependent on clinical details unavailable to the laboratory scientists or pathologists. Therefore, clinicians must become proficient in identifying such erroneous reports, and working with pathologists and laboratory scientists so that they can understand the source of such interferences, correct the results, and then decide what course of action must be followed for proper patient management.

  • Named to Doody’s Core Titles 2013, a collection development tool for health sciences libraries of all sizes, by Doody Enterprises
  • Practical information for both clinicians and laboratory scientists, presented in the form of tables and charts for easy reference
  • Focus on range and sources of interferences rather than details of toxicologic mechanisms which are well covered in toxicology textbooks
  • Covers interferences across endocrine, oncology, hematology, immunohistochemistry, immunology, serology, microbiology, and molecular testing
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Editorial Reviews

From the Publisher
"Dasgupta and Sepulveda offer clinicians and laboratory scientists a guide to error detection and correction in the clinical laboratory that addresses sources of errors in analytical methods and sources of pre-analytical variation."—Reference and Research Book News, August 2013 "This is a very helpful book correlating nonanalytical measurement errors or disease states with anticipated effects on laboratory test results. This would be a must for the laboratory medicine resident who has to explain why results don't correlate with clinical disease."—Doody.com, August 9, 2013
Doody's Review Service
Reviewer: Valerie L. Ng, PhD MD(Alameda County Medical Center/Highland Hospital)
Description: If you've ever pondered why laboratory results don't correlate with clinical disease, you probably want this book. The foreword is written by the inimitable Donald Young, famous for his many authoritative editions of Effects Of Disease On Clinical Laboratory Tests. While Dr. Young's books tabulated the original references for known measurement errors/interferents, this book instead discusses sources of errors holistically.
Purpose: The purpose is to provide a comprehensive guide to sources of errors in laboratory testing, how to identify them, and how to resolve them.
Audience: The book is intended for "laboratory professionals and clinicians who deal with erroneous results on a regular basis." This is pretty much the entire field of healthcare. It would be most helpful to laboratory medicine residents or fellows, or laboratory directors in practice, as they are typically the first to be contacted to explain results discrepant with clinical symptoms. The editors are well respected authorities in this area.
Features: The 22 chapters begin with population effects on laboratory testing (gender, ethnicity, diet, age), specimen collection and processing sources of error, and then move into errors encountered in the various laboratory medicine subspecialties — chemistry, immunology, toxicology, transfusion medicine, hematology, etc. To be very clear, the errors discussed in this book are not analytical measurement errors. They are, instead, errors related to specimen problems (lipemia, hemolysis) or interferents. The two editors specialize in chemistry and toxicology, and the book is heavily weighted toward these disciplines. While the chapters do not follow a standard format, the few that follow the errors through the total test process (preanalytical, analytical, and postanalytical phases) are especially helpful. Similarly, the case studies in many chapters are quite illuminating. For a real eye-opener on how a specimen error can result in death, read the first blood bank case study where the error was a mislabeled specimen (i.e., "wrong blood in tube" or WBIT — it even has its own standard acronym!).
Assessment: This is a very helpful book correlating nonanalytical measurement errors or disease states with anticipated effects on laboratory test results. This would be a must for the laboratory medicine resident who has to explain why results don't correlate with clinical disease.
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Product Details

  • ISBN-13: 9780124157835
  • Publisher: Elsevier Science
  • Publication date: 3/4/2013
  • Edition description: New Edition
  • Pages: 382
  • Sales rank: 1,053,376
  • Product dimensions: 8.60 (w) x 11.00 (h) x 0.90 (d)

Meet the Author

Amitava Dasgupta received his Ph.D degree in Chemistry from the Stanford University and his fellowship training in Clinical Chemistry from the Laboratory Medicine Department of the University of Washington School of Medicine at Seattle. He is a tenured Full Professor of Pathology and Laboratory Medicine at the University of Texas Health Sciences Center located at the Texas Medical Center at Houston. Dr. Dasgupta has published 196 scientific papers, wrote many invited review articles, and edited, co-edited or wrote 15 books. He is on the Editorial Board of five major medical journals including American Journal of Clinical Pathology, Archives of Pathology and Laboratory Medicine, Therapeutic Drug Monitoring, Clinica Chimica Acta and Journal of Clinical Laboratory Analysis.

Jorge Sepulveda received his M.D. from the University of Lisbon, Portugal, and his residency training in Laboratory Medicine and Ph.D. degree in Cell and Molecular Biology from Baylor College of Medicine, Houston, Texas. He is board certified by the American Board of Pathology in Clinical Pathology and Transfusion Medicine. He has published over 35 research articles, review papers and book chapters, and serves as Associate Editor for the Archives of Pathology and Laboratory Medicine. Dr. Sepulveda has broad experience in laboratory medicine as medical director of various clinical laboratories, including at the Houston and Philadelphia Veterans Affairs Medical Centers and at the University of Pittsburgh Presbyterian and Shadyside Hospitals, and currently serves as Associate Medical Director of the Clinical Laboratories at the Columbia University Medical Center Campus of New York-Presbyterian Hospital.

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Table of Contents

Chapter 1. Variation, Errors, and Quality in the Clinical Laboratory

Chapter 2. Effect of Age, Gender, Diet, Exercise and Ethnicity on Laboratory Test Results

Chapter 3. Effect of patient preparation, specimen collection, anticoagulants and preservatives on laboratory tests

Chapter 4. Sample processing and specimen misidentification issues

Chapter 5. Hemolysis, lipemia and high bilirubin: effect on laboratory tests

Chapter 6. Immunoassay design and mechanism of interferences

Chapter 7. Effect of herbal remedies on clinical laboratory tests

Chapter 8. Challenges in routine clinical chemistry: analysis of small molecules

Chapter 9. Challenges in routine clinical chemistry: proteins and enzymes

Chapter 10. Sources of inaccuracy in biochemical genetics analysis

Chapter 11. Challenges in endocrinology testing

Chapter 12. Pitfalls in tumor marker testing

Chapter 13. Issues of interferences in therapeutic drug monitoring

Chapter 14. Limitations of drugs of abuse testing

Chapter 15. Challenges in confirmation testing for drugs of abuse

Chapter 16. Alcohol determination using automated analyzers: limitations and pitfalls

Chapter 17. Pre-analytical issues and interferences in transfusion medicine tests

Chapter 18. Critical issues in immunology and serology testing

Chapter 19. Sources of errors in hematology and coagulation testing

Chapter 20. Challenges in Clinical Microbiology Testing

Chapter 21. Sources of errors in molecular testing

Chapter 22. Problems in Pharmacogenomics Testing

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