Acetaldehyde-Related Pathology: Bridging the Trans-Disciplinary Divide / Edition 8

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Part of the prestigious Novartis Foundation, this is the first book to review the pathology associated with acetaldehyde, a known toxic agent found in cigarette smoke and other pollutants and derived from ingested alcohol, amongst other sources. In the body, acetaldehyde affects several tissues, particularly the brain and liver, causing various diseases, including cancer, alcoholic liver disease and Alzheimer's. Acetaldehyde-Related Pathology describes the toxic effects of acetaldehyde at the tissue and cellular levels, reviewing enzyme biochemistry, transgenic mouse models of alcohol dehydrogenase mutants, and the cell-signalling pathways implicated in alcohol-related pathology. It explores the mechanisms of acetaldehyde-induced damage to tissues, often a first step in carcinogenesis, including the oral cavity, the human airway, and the GI tract. The book considers pharmacological strategies and treatments for reducing oral and intestinal acetaldehyde. Acetaldehyde-Related Pathology features in-depth, round-table discussions by an international array of scientists from major laboratories worldwide involved in studies of acetaldehyde-related pathology. This book is essential reading for anyone interested in the effects of this compound - pathologists, biochemists, toxicologists, cell and molecular biologists.

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Editorial Reviews

Doody's Review Service
Reviewer: Ivan Damjanov, MD (University of Kansas Medical Center)
Description: This book, volume 285 in the well known Novartis Foundation Symposium series, deals with acetaldehyde and its effects on the body. These are the proceedings of the symposium held in London in September 2006.
Purpose: The main aim of this series is to keep the scientific community informed about the topics discussed at the Novartis Symposia. It also serves as a depository of the material that was presented at those meetings. These are worthy objectives and one can only hope that the Novartis Foundation, like its predecessor (Ciba Foundation), will continue publishing future volumes of this series in the years to come.
Audience: The book was written for scientists working in basic sciences, nutrition research, clinical laboratories, toxicology and clinics, and especially those who are interested in the effects of alcohol on the human body. The editors, Derek J Chadwick, who also served as the organizer, and Jamie Goode, as well as the Chair, Peter Emery, are well known scientists. The invited contributors who participated in the symposium are also well known authorities in their respective fields of endeavor.
Features: This book contains 16 articles, together with a general introduction and transcripts of discussions that followed after each presentation. The authors discuss how acetaldehyde gets into body, how it is metabolized, how it causes damage, which tissues are affected, and what can be done about it. The presentations, whenever needed, are illustrated with graphs and diagrams. The references are current and well chosen.
Assessment: Like the other volumes in the series, this one is a slender book. It was carefully planned, the presentations are well focused, and the volume is well produced. The presentations are concise, to the point, and quite informative. Primarily the book will be of interest to specialists. Like all other volumes in this series, this one also has archival value and will be found on the shelves of most scientific biomedical libraries.
From the Publisher
"…will be found on the shelves of most scientific biomedical libraries." (Doody's Book Reviews)
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Product Details

  • ISBN-13: 9780470057667
  • Publisher: Wiley
  • Publication date: 6/15/2007
  • Series: Novartis Foundation Symposia Series
  • Edition number: 8
  • Pages: 286
  • Product dimensions: 6.36 (w) x 9.49 (h) x 0.71 (d)

Meet the Author

The Novartis Foundation is an international scientific andeducational charity which promotes the study and general knowledgeof science and in particular encourages international co-operationin scientific research.
Chairman: Peter Emery

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Table of Contents

Symposium on Acetaldehyde-related pathology: bridging thetrans-disciplinary divide, held at the Novartis Foundation, London5–7th September.

Editors: Derek J. Chadwick (Organizer) and JamieGoode

This symposium is based on a proposal made by Victor Preedy,Peter Emery and Mikko Salaspuro

Peter Emery Chair’s introduction.

David W. Crabb and Suthat LiangpunsakulAcetaldehyde generating enzyme systems: roles of alcoholdehydrogenase, CYP2E1 and catalase, and speculations on the role ofother enzymes and processes.


Richard A. Deitrich, Dennis Petersen and VasilisVasiliou Removal of acetaldehyde from the body.


Shih-Jiun Yin and Giia-Sheun Peng Acetaldehyde,polymorphisms and the cardiovascular system.


Jun Ren Acetaldehyde and alcoholic cardiomyopathy:lessons from the ADH and ALDH2 transgenic models.


Mikko Salaspuro Interrelationship between alcohol,smoking, acetaldehyde and cancer.


Hiroto Matsuse, Chizu Fukushima, Terufumi Shimoda, SadahiroAsai and Shigeru Kohno Effects of acetaldehyde on humanairway constriction and infl ammation.


Helmut K. Seitz The role of acetaldehyde inalcohol-associated cancer of the gastrointestinal tract.


Robert Tardif The determination of acetaldehyde inexhaled breath.


Mostofa Jamal, Kiyoshi Ameno, Mitsuru Kumihashi, WeihuanWang, Ikuo Uekita and Iwao Ijiri Ethanol andacetaldehyde: in vivo quantitation and effects oncholinergic function in rat brain.


Ville Salaspuro Pharmacological treatments and strategiesfor reducing oral and intestinal acetaldehyde.


Victor R. Preedy, David W. Crabb, Jaume Farrés andPeter W. Emery Alcoholic myopathy and acetaldehyde.


Onni Niemelä Acetaldehyde adducts incirculation.


General discussion.

M. Apte, J. McCarroll, R. Pirola and J. WilsonPancreatic MAP kinase pathways and acetaldehyde.


Shivendra D. Shukla, Youn Ju Lee, Pil-hoon Park andAnnayya R. Aroor Acetaldehyde alters MAP kinase signallingand epigenetic histone modifi cations in hepatocytes.


Paul J. Thornalley Endogenous α-oxoaldehydes andformation of protein and nucleotide advanced glycation endproductsin tissue damage.


C. J. Peter Eriksson Measurement of acetaldehyde: whatlevels occur naturally and in response to alcohol?


Final discussion.

Contributors Index.

Subject Index.

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