Actin-Binding Proteins and Disease / Edition 1

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Overview

There are scattered reports in the published literature citing relationships between actin, actin-binding proteins and disease. This volume brings this information together for the first time, with a focus on human disorders. The volume is relevant to a wide readership including cell biologists interested in understanding how structural and functional changes in proteins impact on the organism as a whole.

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Product Details

  • ISBN-13: 9780387717470
  • Publisher: Springer New York
  • Publication date: 10/28/2007
  • Series: Protein Reviews Series , #8
  • Edition description: 2008
  • Edition number: 1
  • Pages: 348
  • Product dimensions: 6.20 (w) x 9.30 (h) x 1.00 (d)

Table of Contents

Overview of actin.- Actin Genetic Diseases.- Actin-binding drugs.- Filamentous actin as an autoantigen.- Actin Binding Protein Function and its Relation to Disease Pathology.- ADF/cofilin, actin dynamics and disease.- Gelsolin and disease.- Profilin and disease.- The roles of thymosin beta4 in cell migration and cell-to-cell signalling in disease.- Actin and actin binding proteins in cancer progression and metastasis.- Defects in actin and actin-binding proteins in leukocytes.- The role of PIP2 in actin, actin-binding proteins and disease.- Intracellular pathogens and the actin cytoskeleton.- Actin and its binding proteins in heart failure.

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