Acute Liver Failure

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Overview

Acute liver failure (ALF) is a distinct clinical syndrome which crosses medical disciplines. A relatively rare condition, ALF remains a major focus of clinical and research attention and with the advent of transplantation, understanding ALF management has taken on new urgency.This volume, the first dedicated to ALF, describes the etiology, pathology and treatment of this imp ortant syndrome. Also covered are consensus techniques in liver transplantations, liver assist devices and future treatments.

The book contains predominantly black-and-white illustrations, with some color illustrations.

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Editorial Reviews

Elizabeth Ann Fagan
This slim book is the first to be dedicated to acute liver failure. The transatlantic editors have taken a refreshing approach by including contributions from newcomers alongside established authorities and highlighting diversities across different continents. The chapters read easily as individual essays; some are surprisingly personal. The focus is practical rather than on basic science. Cytokines and immunology take precedence over virology. The most obvious omission—advances in molecular pathogeneses of fulminant viral hepatitis, especially hepatitis B—probably reflects the paucity of references cited after 1994. This book is crafted to appeal at all levels and offers something for everyone involved in this complex, multidisciplinary field. Chapters 11 and 12 give erudite accounts of the pathophysiology of circulatory derangements and cerebral edema. The 35 color plates complement the chapter by Dr. Bernard Portmann and Dr. Romel Saxena, which becomes one of the most comprehensive treatises in pathology. Chapters 15 and 16 contrast clinical practice and epidemiologies between Europe and the U.S.; the many discordances should serve as a caution against direct extrapolation of data from transatlantic experiences. Surgical aspects are well represented. That six chapters address liver assist devices reflects rekindled trends in research rather than new approaches with proven efficacy and practical feasibility. Hepatectomy alone is out of favor. Instead, one chapter heralds auxiliary liver transplantation as a significant advance likely to gain credibility as a bridge to potential spontaneous regeneration of native liver while optimizing the supply of donor organs.This book is a landmark in the field and worthy of monograph status. Many citations pay homage to the pioneering work of King's College and other devotees. Future editions could be enriched by acknowledging the contributions of healthcare teams who have dedicated lives and careers to acute liver failure, as well as their ""significant others.""
From The Critics
Reviewer: Elizabeth Ann Fagan, MD, MRCP (Rush University Medical Center)
Description: This slim book is the first to be dedicated to acute liver failure. The transatlantic editors have taken a refreshing approach by including contributions from newcomers alongside established authorities and highlighting diversities across different continents.
Purpose: The chapters read easily as individual essays; some are surprisingly personal. The focus is practical rather than on basic science. Cytokines and immunology take precedence over virology. The most obvious omission — advances in molecular pathogeneses of fulminant viral hepatitis, especially hepatitis B — probably reflects the paucity of references cited after 1994.
Audience: This book is crafted to appeal at all levels and offers something for everyone involved in this complex, multidisciplinary field.
Features: Chapters 11 and 12 give erudite accounts of the pathophysiology of circulatory derangements and cerebral edema. The 35 color plates complement the chapter by Dr. Bernard Portmann and Dr. Romel Saxena, which becomes one of the most comprehensive treatises in pathology. Chapters 15 and 16 contrast clinical practice and epidemiologies between Europe and the U.S.; the many discordances should serve as a caution against direct extrapolation of data from transatlantic experiences. Surgical aspects are well represented. That six chapters address liver assist devices reflects rekindled trends in research rather than new approaches with proven efficacy and practical feasibility. Hepatectomy alone is out of favor. Instead, one chapter heralds auxiliary liver transplantation as a significant advance likely to gain credibility as a bridge to potential spontaneous regeneration of native liver while optimizing the supply of donor organs.
Assessment: This book is a landmark in the field and worthy of monograph status. Many citations pay homage to the pioneering work of King's College and other devotees. Future editions could be enriched by acknowledging the contributions of healthcare teams who have dedicated lives and careers to acute liver failure, as well as their "significant others."

3 Stars from Doody
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Product Details

  • ISBN-13: 9780521188944
  • Publisher: Cambridge University Press
  • Publication date: 3/3/2011
  • Edition description: Reissue
  • Pages: 336
  • Product dimensions: 7.00 (w) x 9.90 (h) x 0.90 (d)

Table of Contents

Preface
Foreword
Acknowledgments
Contributors
1 Classification and clinical syndromes of acute liver failure 1
2 Viral hepatitis and acute liver failure 10
3 Drug hepatoxicity as a cause of acute liver failure 19
4 Acetaminophen-induced acute liver failure 32
5 Unusual causes of acute liver failure 43
6 Pediatric aspects of acute liver failure 53
7 Role of cytokines and immune mechanisms in acute liver failure 67
8 Pathology of acute liver failure 79
9 Hepatocyte replication and liver regeneration 93
10 Medical management of acute liver failure 115
11 Circulatory derangements, monitoring, and management: heart, kidney, and brain 132
12 Brain edema and intracranial hypertension in acute liver failure 144
13 Management of infection in acute liver failure 158
14 Prognosis and consideration of transplantation 173
15 Liver transplantation in patients with acute liver failure: the European experience 186
16 Transplantation for acute liver failure: the American experience 201
17 Auxiliary liver transplantation 211
18 Extracorporeal liver support: historical background and critical analysis 223
19 Hepatocyte culture and bioreactor design for liver support systems 245
20 Clinical experience with an extracorporeal liver assist device 255
21 Treatment of acute liver failure by high volume plasmapheresis 267
22 Dialysis/adsorption techniques for acute liver failure 278
23 Hepatocyte transplantation in liver failure and inherited metabolic disorders 285
Index 301
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