Adoptive Immunotherapy: Methods and Protocols / Edition 1

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Overview

Experts from various fields contributed to this comprehensive collection of state-of-the-art methods for adoptive immunotherapy. Adoptive transfer of tailored antigen-specific immune cells and/or optimally designed immunological effector molecules is an elegant and promising approach to establish or restore protective immune responses. Recent technical advances and specific methods from the areas of dendritic cell therapy, generation of antigen-specific cytotoxic T cells, and anti-tumor treatment with specific antibodies have been compiled, with a an emphasis on preclinical and clinical applications.

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Editorial Reviews

Doody's Review Service
Reviewer: Marion C. Cohen, PhD (SUNY Downstate Medical Center)
Description: This book, part of a series entitled Methods in Molecular Medicine, is a compendium of techniques that are currently being used to develop new treatment strategies that take advantage of what we currently know about the human immune system. Within the series, the format of each chapter generally consists of a discussion of the principle(s) involved in the technique, a list of reagents and equipment, step-by-step laboratory instructions, and tips on troubleshooting and avoiding known pitfalls. Each chapter also has a reference list.
Purpose: According to the editors, the purpose is to provide a collection of state-of-the-art techniques to effectively study the adoptive transfer of tailored antigen-specific immune cells for application to human diseases. While there are many methods books available, this one provides carefully described protocols as well as accompanying notes that give hints on troubleshooting and avoiding possible pitfalls. Thus, the book is a useful addition to the library of a researcher who is trying to develop clinical protocols for treatment.
Audience: The editors suggest that a wide variety of basic scientists and clinicians will benefit from this book. Rather than focusing on the target audience, it is perhaps more important that the techniques that are discussed are applicable to many fields including hematology, oncology, molecular medicine, clinical immunology, biotechnology, molecular immunology, immunology, cell biology, biochemical methods, and biomathematics. The authors of each chapter are experts in the techniques they discuss.
Features: The book presents protocols to be used to study dendritic cells, T cells, monoclonal antibodies, bone marrow transplantation for both clinical and preclinical studies. The chapters relating to these individual topics are grouped together and there is a logical flow to the order of the chapters. In addition to the methods chapters, there are several chapters that do not describe actual techniques but describe clinical applications of these cells and reagents. The figures seem to be appropriate for each chapter. All are black and white and, while color is always nice, they convey the information adequately. Each chapter has a list of references. The latest citation is 2004 and there are relatively few of these.
Assessment: This is a useful techniques book to have in the laboratory. The methods seem well described and the section of notes — the little helpful hints that rarely show up in this kind of book — is a very nice touch. If a laboratory is focused on immunotherapy, this book would make a nice addition to its library.
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Product Details

  • ISBN-13: 9781588294067
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 11/30/2004
  • Series: Methods in Molecular Medicine Series , #109
  • Edition description: 2005
  • Edition number: 1
  • Pages: 500
  • Product dimensions: 6.20 (w) x 9.30 (h) x 1.30 (d)

Table of Contents

Exploiting Dendritic Cells for Active Immunotherapy of Cancer and Chronic Infection

David O'Neill and Nina Bhardwaj

A Mathematical Approach for Optimizing Dendritic Cell-Based Immunotherapy

Gennady Bocharov, Neville J. Ford, and Burkhard Ludewig

Delivery of Tumor Antigens to Dendritic Cells Using Biodegradable Microspheres

Ying Waeckerle-Men, Bruno Gander, and Marcus Groettrup

RNA Transfection of Dendritic Cells

Frank Grünebach, Martin R. Müller, and Peter Brossart

Isolation and Generation of Clinical-Grade Dendritic Cells Using the CliniMACS System

John D. M. Campbell, Christoph Piechaczek, Gregor Winkels, Edith Schwamborn, Daniela Micheli, Sonja Hennemann, and Jürgen Schmitz

Generation of Clinical Grade Monocyte-Derived Dendritic Cells Using the CliniMACS System

Thomas Putz, Hubert Gander, Reinhold Ramoner, Claudia Zelle-Rieser, Andrea Rahm, Walter Nussbaumer, Georg Bartsch, Lorenz Höltl, and Martin Thurnher

Adenoviral Transduction of Dendritic Cells

Rienk Offringa, Kitty Kwappenberg, Martijn Rabelink, Delphine Rea, and Rob Hoeben

Generation of Autologous Peptide- and Protein-Pulsed Dendritic Cells for Patient-Specific Immunotherapy

David O'Neill and Nina Bhardwaj

Phenotypical and Functional Characterization of Clinical-Grade Dendritic Cells

I. Jolanda M. de Vries, Gosse J. Adema, Cornelis J. A. Punt, and Carl G. Figdor

Dendritic Cells in Clinical Trials for Multiple Myeloma

Volker L. Reichardt and Peter Brossart

Identification of Tumor-Associated Autoantigens With SEREX

Özlem Türeci, Dirk Usener, Sandra Schneider, and Ugur Sahin

Application of Proteomics and Protein Analysis for Biomarker and Target Finding for Immunotherapy

Petra Weingarten, Petra Lutter, Andreas Wattenberg, Martin Blueggel, Sonja Bailey, Joachim Klose, Helmut E. Meyer, and Christoph Huels

Isolation and Expansion of Tumor-Reactive Cytotoxic T-Cell Clones for Adoptive Immunotherapy

Helga Bernhard, Burkhard Schmidt, Dirk H. Busch, and Christian Peschel

Tracking Adoptively Transferred Antigen-Specific T-Cells With Peptide/MHC Multimers

Norbert Meidenbauer and Andreas Mackensen

Gene Transfer of MHC-Restricted Receptors

Helmut W. H. G. Kessels, Monika C. Wolkers, and Ton N. M. Schumacher

Immunotherapy With CTL Restricted by Nonself MHC

Liquan Gao, Anne-Marie Downs, and Hans J. Stauss

Designing TCR for Cancer Immunotherapy

Ralf-Holger Voss, Jürgen Kuball, Matthias Theobald

Isolation and Expansion of Tumor-Specific CD4+ T-Cells by Means of Cytokine Secretion

Christian Becker

Methods for the Ex Vivo Characterization of Human CD8+ T Subsets Based on Gene Expression and Replicative History Analysis

Nathalie Rufer, Patrick Reichenbach, and Pedro Romero

Regulatory T Cells in Antitumor Therapy: Isolation and Functional Testing of CD4+CD25+ Regulatory T-Cells

Helmut Jonuleit and Edgar Schmitt

Monoclonal Antibody-Based Strategies in Autoimmunity and Transplantation

Lucienne Chatenoud

Producing Bispecific and Bifunctional Antibodies

Dipankar Das and Mavanur R. Suresh

Antibody-Cytokine Fusion Proteins for the Therapy of Cancer

Gustavo Helguera and Manuel L. Penichet

Synthesis and Biological Evaluation of a Paclitaxel Immunoconjugate

Ahmad Safavy and Kevin P. Raisch

Cytotoxic Tumor Targeting With scFv Antibody-Modified Liposomes

Cornelia Marty and Reto A. Schwendener

Intravenous Immunoglobin Treatment for Fibrosis, Atherosclerosis, and Malignant Conditions

Ilan Krause and Yehuda Shoenfeld

Study of T-Cell Costimulatory Blockade In Vivo at a Single Cell Level

Minh Diem Vu and Xian Chang Li

Stem Cell Transplantation: Graft-Mediated Antileukemia Effects

William J. Hogan and Hans Joachim Deeg

Influence of Radiation Prools on Graft-vs-Host Disease Incidence After Bone-Marrow Transplantation in Experimental Models

Sebastian Schwarte and Matthias W. Hoffmann

Induction of Chimerism and Tolerance Using Freshly Purified or Cultured Hematopoietic Stem Cells in Nonmyeloablated Mice

Nikos Emmanouilidis and Christian P. Larsen

Induction of Mixed vs Full Chimerism to Potentiate GVL Effects After Bone-Marrow Transplantation

Markus Y. Mapara and Megan Sykes

Application of Donor Lymphocytes Expressing a Suicide Gene for Early GVL Induction and Later Control of GVH Reactions After Bone-Marrow Transplantation

Attilio Bondanza, Fabio Ciceri, and Chiara Bonini

Index

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