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Doody's Review ServiceReviewer: Valerie L. Ng, PhD MD(Alameda County Medical Center/Highland Hospital)
Description: This comprehensive book covers all testing occurring in a conventional hematology clinical laboratory ("wet hematology").
Purpose: The purpose is to provide a comprehensive book on the best practices for laboratory hematology, with full consideration of increasing diversity of testing, automation, cost containment, and accountability.
Audience: This book is intended for practicing hematologists and clinical laboratory scientists and other technical staff working in a clinical hematology laboratory. This book will also be useful to directors of hematology laboratories and clinical laboratories, laboratory medicine/clinical pathology residents, and anyone else interested in clinical hematology laboratory practice.
Features: There are six major sections in this book — peripheral blood counts, hemoglobinometry, hemoglobin variants, erythrocyte sedimentation, hematopoietic factors, and coagulation testing. Each section covers in depth the technology underlying multiple methods, required quality control, and standardization with national and international guidelines and/or regulations. References for each chapter are extensive. The section on coagulation testing is excellent. The chapter on standardization and control of oral anticoagulation testing is exceptional, in that the reader has in one place all the instructions, statistical theory and protocol for determining local sensitivity indexes for chronic anticoagulation therapy! The chapter on automated cell counters is also excellent and has a well reasoned discussion on setting limits to minimize the number of specimens for microscopic review. In contrast, there is uneven coverage of molecular hematology diagnostic tests. For example, there is no mention of molecular testing for thalassemia or hemoglobinopathy, yet there is a nice discussion (and algorithm) for hypercoagulability evaluations (including molecular and functional coagulation tests). Finally, and surprising for a hematology book, this book is entirely in black and white. No photomicrographs are to be found, and examples of laboratory data (e.g., hemoglobin electrophoresis) are reproduced in black and white. I miss the color!
Assessment: This is a nice reference book for technical staff and directors of clinical hematology laboratories.