Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis: Volume 1 / Edition 1

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Overview

Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis Volume 3 is vital to professionals and academicians working in drug development and bioengineering. Both basic and clinical scientists will benefit from this work. This book contains chapters by leading researchers in pharmacokinetic/Pharmacodynamic modeling and will be of interest to anyone involved with the application of pharmacokinetic and pharmacodynamics to drug development. The use of mathematical modeling and associated computational methods is central to the study of the absorption, distribution and elimination of therapeutic drugs (pharmacokinetics) and to understanding how drugs produce their effects (pharmacodynamics). From its inception, the field of pharmacokinetics and pharmacodynamics has incorporated methods of mathematical modeling, simulation and computation in an effort to better understand and quantify the processes of uptake, disposition and action of therapeutic drugs. These methods for pharmacokinetic/pharmacodynamic systems analysis impact all aspects of drug development. In vitro, animal and human testing, as well as drug therapy are all influenced by these methods. Modeling methodologies developed for studying pharmacokinetic/pharmacodynamic processes confront many challenges. This is related in part to the severe restrictions on the number and type of measurements that are available from laboratory experiments and clinical trials, as well as the variability in the experiments and the uncertainty associated with the processes themselves. The contributions are organized in three main areas: Mechanism-Based PK/PD, Pharmacometrics and Pharmacotherapy. Both professionals and academics will profit from this extensive work.
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Editorial Reviews

Booknews
The movement and effect of drugs in bodies is explored in 17 papers covering the physiological and biochemical basis, mathematical models, estimation and control, and measurement and delivery. Theoretical and experimental approaches are included. Annotation c. Book News, Inc., Portland, OR (booknews.com)
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Product Details

  • ISBN-13: 9780306440281
  • Publisher: Springer US
  • Publication date: 11/1/2007
  • Edition description: 1991
  • Edition number: 1
  • Pages: 211
  • Product dimensions: 10.00 (w) x 7.00 (h) x 0.56 (d)

Table of Contents

Preface
Physiological modeling of the small intestine in drug absorption 3
Intracellular metabolism of Lamivudine 33
Mechanism-based pharmacodynamic modeling for prediction of exposure response 49
Mechanism-based PK/PD modeling of Digoxin : role of receptor heterogeneity and postreceptor events 67
Pharmacodynamics and pharmacogenomics of corticosteroids : microarray studies 85
Bayesian inference in physiologically-based pharmacokinetic modeling : application to anticancer drug development 105
Monte Carlo parametric expectation maximization (MC-PEM) method of analyzing population pharmacokinetic/pharmacodynamic data 135
Application of Markov chain Monte Carlo methods to inverse problems in PK/PD 165
Regenerative Markov chain Monte Carlo methods for pharmacokinetic/pharmacodynamic estimation 179
Vizstruct : a multidimensional visualization algorithm for gene expression 197
Modeling and simulation of effects of adherence, pharmacokinetic, and pharmacodynamic characteristics in development of resistance to HIV regimens in treatment-naive patients 211
Mechanistic PK/PD modeling of antiretroviral therapies in AIDS clinical trials 221
Dose individualization for high-dose anti-cancer chemotherapy 239
Toward model-based chemotherapy treatment design 255
Control of uncertain pharmacodynamic systems 275
Contributors 295
Participants 305
Index 317
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