Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis: Volume 1 / Edition 1

Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis: Volume 1 / Edition 1

by Marcos Briano
     
 

Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis Volume 3 is vital to professionals and academicians working in drug development and bioengineering. Both basic and clinical scientists will benefit from this work. This book contains chapters by leading researchers in pharmacokinetic/Pharmacodynamic modeling and will be of interest to anyone… See more details below

Overview

Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis Volume 3 is vital to professionals and academicians working in drug development and bioengineering. Both basic and clinical scientists will benefit from this work. This book contains chapters by leading researchers in pharmacokinetic/Pharmacodynamic modeling and will be of interest to anyone involved with the application of pharmacokinetic and pharmacodynamics to drug development. The use of mathematical modeling and associated computational methods is central to the study of the absorption, distribution and elimination of therapeutic drugs (pharmacokinetics) and to understanding how drugs produce their effects (pharmacodynamics). From its inception, the field of pharmacokinetics and pharmacodynamics has incorporated methods of mathematical modeling, simulation and computation in an effort to better understand and quantify the processes of uptake, disposition and action of therapeutic drugs. These methods for pharmacokinetic/pharmacodynamic systems analysis impact all aspects of drug development. In vitro, animal and human testing, as well as drug therapy are all influenced by these methods. Modeling methodologies developed for studying pharmacokinetic/pharmacodynamic processes confront many challenges. This is related in part to the severe restrictions on the number and type of measurements that are available from laboratory experiments and clinical trials, as well as the variability in the experiments and the uncertainty associated with the processes themselves. The contributions are organized in three main areas: Mechanism-Based PK/PD, Pharmacometrics and Pharmacotherapy. Both professionals and academics will profit from this extensive work.

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Product Details

ISBN-13:
9780306440281
Publisher:
Springer US
Publication date:
11/01/2007
Edition description:
1991
Pages:
212
Product dimensions:
10.00(w) x 7.00(h) x 0.56(d)

Related Subjects

Table of Contents

Preface
Physiological modeling of the small intestine in drug absorption3
Intracellular metabolism of Lamivudine33
Mechanism-based pharmacodynamic modeling for prediction of exposure response49
Mechanism-based PK/PD modeling of Digoxin : role of receptor heterogeneity and postreceptor events67
Pharmacodynamics and pharmacogenomics of corticosteroids : microarray studies85
Bayesian inference in physiologically-based pharmacokinetic modeling : application to anticancer drug development105
Monte Carlo parametric expectation maximization (MC-PEM) method of analyzing population pharmacokinetic/pharmacodynamic data135
Application of Markov chain Monte Carlo methods to inverse problems in PK/PD165
Regenerative Markov chain Monte Carlo methods for pharmacokinetic/pharmacodynamic estimation179
Vizstruct : a multidimensional visualization algorithm for gene expression197
Modeling and simulation of effects of adherence, pharmacokinetic, and pharmacodynamic characteristics in development of resistance to HIV regimens in treatment-naive patients211
Mechanistic PK/PD modeling of antiretroviral therapies in AIDS clinical trials221
Dose individualization for high-dose anti-cancer chemotherapy239
Toward model-based chemotherapy treatment design255
Control of uncertain pharmacodynamic systems275
Contributors295
Participants305
Index317

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