Advances in Bladder Research

Overview

The aim of Bladder Research Congress, San Francisco, California, April 23-25, 1998, was to provide a forum for authoritative investigators who are actively involved in the various disciplines which define the leading edges of bladder research. It is important for such investigators to continue to meet regularly for the purpose of discussing the latest developments in their individual fields, to analyze the significance of current research, to discuss new tactics for unresolved problems, to critically evaluate ...

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Paperback (Softcover reprint of the original 1st ed. 1999)
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Overview

The aim of Bladder Research Congress, San Francisco, California, April 23-25, 1998, was to provide a forum for authoritative investigators who are actively involved in the various disciplines which define the leading edges of bladder research. It is important for such investigators to continue to meet regularly for the purpose of discussing the latest developments in their individual fields, to analyze the significance of current research, to discuss new tactics for unresolved problems, to critically evaluate current theories, and to develop new theories and approaches as needed. The two and a half day meeting was organized into five half day sessions, with each session encompassing one of five topics: (1) Epithelial-Mesenchymal Interactions; (2) Ex­ tracellular Matrix and Muscle; (3) Nerves and Pharmacology; (4) Infection and Immunol­ ogy; and (5) Oncology. Each session was introduced by a moderator followed by five to six invited expert speakers with time for extensive interaction from the participants. Two late-afternoon poster sessions allowed further interactions between investigators. This book documents the proceedings of the Bladder Research Congress. It is organ­ ized into the five half-day sessions of the meeting with moderators overview and an edited transcription of discussions that followed each presentation. I would like to thank Sarah Burke and the Office of Continuing Medical Education, USCF; Joanne Hayward, Editorial Assistant; and Miriam Escamilla, Administrative Assis­ tant. I hope you find this resource useful. Laurence S. Baskin, M.D.

The book contains black-and-white illustrations.

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Editorial Reviews

Booknews
This volume is organized to represent the five half-day sessions that comprised the International Bladder Research Congress held in April 1998 in San Francisco, California, each covering one of five topics: epithelial-mesenchymal interactions; extracellular matrix and muscle; nerves and pharmacology; infection and immunology; and oncology. The 36 contributions also include two poster sessions and an edited transcription of discussions and question-and-answer sessions that followed each presentation. Contributors come from hospitals in the US, the UK, Europe, and Japan. Annotation c. Book News, Inc., Portland, OR (booknews.com)
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Product Details

  • ISBN-13: 9781461371472
  • Publisher: Springer US
  • Publication date: 4/30/2013
  • Series: Advances in Experimental Medicine and Biology Series, #462
  • Edition description: Softcover reprint of the original 1st ed. 1999
  • Edition number: 1
  • Pages: 493
  • Product dimensions: 7.00 (w) x 10.00 (h) x 1.03 (d)

Table of Contents

Section I. Epithelial-Mesenchymal Interactions in the Bladder
Overview of Epithelial-Mesenchymal Interactions in the Bladder 3
1. Uroplakins as Markers of Urothelial Differentiation 7
2. Urothelial Tissue Regulation: Unraveling the Role of the Stroma 19
3. Creation of Bladder Tissue in Vitro and in Vivo: A System for Organ Replacement 31
4. Reconstruction of the Urinary Bladder by Auto-Augmentation, Enterocystoplasty, and Composite Enterocystoplasty 43
5. Epithelial-Mesenchymal Interactions in the Bladder: Implications for Bladder Augmentation 49
6. Serosal Thickening, Smooth Muscle Cell Growth, and Phenotypic Changes in the Rabbit Bladder Wall during Outflow Obstruction and Regeneration 63
7. Replicative Senescence in Human Uroepithelial Cells 83
8. Ultrastructural Smooth Muscle Ontogeny of the Rat Bladder 93
Discussion: Epithelial-Mesenchymal Interactions in the Bladder 103
Section II. Muscle and Extracellular Matrix in the Bladder
Overview of Muscle and Extracellular Matrix in the Bladder 117
9. Fetal Bladder Physiology 121
10. Developmental Aspects of the Contractile Smooth Muscle Component in Small Intestinal Submucosa Regenerated Urinary Bladder 129
11. Contractile Protein Changes in Urinary Bladder Smooth Muscle following Outlet Obstruction 137
12. Calcium Ion Homeostasis in Urinary Bladder Smooth Muscle 155
13. Cyclooxygenase-2: A Key Regulator of Bladder Prostaglandin Formation 171
14. Role of Angiotensin II in Bladder Smooth Muscle Growth and Function 183
15. New Concepts on the Normal and Abnormal Developing Bladder 193
16. Biochemical and Physiological Characterization of the Urinary Bladder in Ehlers-Danlos Syndrome 201
17. The Role of Collagen in Bladder Filling 215
Discussion: Muscle and Extracellular Matrix in the Bladder 225
Section III. Nerves and Pharmacology in the Bladder
Overview of Nerves and Pharmacology in the Bladder 237
18. Pathways for Relaxation of Detrusor Smooth Muscle 241
19. Maturation of Bladder Reflex Pathways during Postnatal Development 253
20. Subcellular Distribution of Free Fatty Acids, Phospholipids, and Endogenous Lipase Activity of Rabbit Urinary Bladder Smooth Muscle and Mucosa 265
21. Effects of Glutamate Receptor Antagonists on Lower Urinary Tract Function in Conscious Unanesthetized Rats 275
22. Observations from the Spontaneously Hypertensive Rat: Insight into NGF Regulation and Noradrenergic Hyper-Innervation in the Lower Urinary Tract 283
23. Role of Na[superscript +]-K[superscript +]-ATPase Activity in Regulation of Detrusor Contractility and Diabetic Bladder Dysfunction 293
24. Restoration of Bladder Function in Spastic Neropathic Bladder Using Sacral Deafferentation and Different Techniques of Neurostimulation 303
Discussion: Nerves and Pharmacology 311
Section IV. Infection, Immunology, and Interstitial Cystitis in the Bladder
Overview of Infection, Immunology, and Interstitial Cystitis in the Bladder 323
25. Pathophysiology of Bacterial Cystitis 325
26. Role of Vaginal Colonization in Urinary Tract Infections (UTIs) 339
27. Host Factors in Susceptibility to Urinary Tract Infections 351
28. Induction of Nitric Oxide Synthase with Urinary Tract Infections 359
29. Interferon Alpha for the Treatment of Superficial Bladder Cancer 371
Discussion: Infection, Immunology, and Interstitial Cystitis in the Bladder 387
Section V. Cancer of the Bladder
Overview of Cancer of the Bladder 395
30. Urokinase (u-PA) and the u-PA Receptor: Modulation of in Vitro Invasiveness of Human Bladder Cancer Cell Lines 399
31. The Role of Matrix Metalloproteinases in an in Vitro Model of Bladder Tumor Invasion 413
32. DNA Methylation in Development of Bladder Cancer 419
33. Cellular Proliferation and Cell-Cell Cycle Regulatory Proteins as Prognostic Markers for Transitional Cell Carcinoma of the Bladder 425
34. Urothelial Differentiation and Bladder Cancer 437
35. Complexity, Retinoid-Responsive Gene Networks, and Bladder Carcinogenesis 449
36. Tumor Cell Motility: A Novel Therapeutic Target in Bladder Carcinoma, Experimental and Clinical Results 469
Discussion: Cancer of the Bladder 477
Index 485
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