Advances in Cancer Research / Edition 1

Advances in Cancer Research / Edition 1

by George F. Vande Woude
     
 

ISBN-10: 012006667X

ISBN-13: 9780120066674

Pub. Date: 01/28/1995

Publisher: Elsevier Science & Technology Books

Advances in Cancer Research provides invaluable information on the exciting and fastmoving field of cancer research. Here, once again, outstanding and original reviews are presented and include:

Insights into the Evolution of Lymphomas induced by Epstein-Barr Virus

Recent Advances in the Research of Hepatitis B Virus-Related Hepatocellular Carcinoma:

…  See more details below

Overview

Advances in Cancer Research provides invaluable information on the exciting and fastmoving field of cancer research. Here, once again, outstanding and original reviews are presented and include:

Insights into the Evolution of Lymphomas induced by Epstein-Barr Virus

Recent Advances in the Research of Hepatitis B Virus-Related Hepatocellular Carcinoma: Epidemiologic and Molecular Biological Aspects

The ATM-Chk2 and ATR-Chk1 Pathways in DNA Damage Signaling and Cancer

microRNAs in Cancer: From Bench to Bedside

Product Details

ISBN-13:
9780120066674
Publisher:
Elsevier Science & Technology Books
Publication date:
01/28/1995
Pages:
328
Product dimensions:
6.00(w) x 9.00(h) x (d)

Table of Contents

Insights into the Evolution of Lymphomas Induced by Epstein-Barr Virus David Vereide Bill Sugden

I EBV and its Extensive Presence in Lymphomas 2

II Tumor Cells Differ in Their Dependence on EBV 6

III A Model for EBV-Induced Lymphomagenesis 9

IV Conclusion 14

References 15

Recent Advances in the Research of Hepatitis B Virus-Related Hepatocellular Carcinoma: Epidemiologic and Molecular Biological Aspects Jia-Horng Kao Pei-Jer Chen Ding-Shinn Chen

I Introduction 22

II Factors Associated with HCC Development in Patients with Chronic HBV Infection 26

III Viral Factors in HBV-Related HCC 27

IV Nonviral Factors in HBV-Related HCC 44

V Primary Prevention of HBV-Related HCC 45

VI Molecular Carcinogenesis of HBV-Related HCC 46

VII Genetic Variations and HCC: Virus and Host Perspectives 50

VIII Conclusions 60

References 61

The ATM-Chk2 and ATR-Chk1 Pathways in DNA Damage Signaling and Cancer Joanne Smith Lye Mun Tho Naihan Xu David A. Gillespie

I Introduction 74

II Activation of the ATM-Chk2 and ATR-Chk1 DNA Pathways 75

III Checkpoint Functions of the ATM-Chk2 and ATR-Chk1 Pathways 79

IV The Three Rs of Damage Signaling: Resection, Recombination, and Repair 84

V ATM-Chk2 and ATR-Chk1 Pathway Alterations in Cancer 87

VI Exploiting Homologous Recombinational Repair (HRR) Defects for Cancer Therapy 92

VII DNA Damage Signaling as a Barrier to Tumorigenesis 95

VIII Checkpoint Suppression as a Therapeutic Principle 97

IX Future Perspectives 102

References 104

microRNAs in Cancer: From Bench to Bedside Maria Angelica Cortez Cristina Ivan Peng Zhou Xue Wu Mircea Ivan George Adrian Calin

I Introduction 114

II Alterations of miRNA Expression in Cancer 115

III Causes of miRNA Expression Variations 117

IV Pathways Involving miRNA Alterations 126

V Clinical Applications 136

VI Concluding Remarks 143

References 144

Index 159

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