Advances in Cancer Research

Advances in Cancer Research

by George F. Vande Woude
     
 

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ISBN-10: 0120066831

ISBN-13: 9780120066834

Pub. Date: 10/28/2001

Publisher: Elsevier Science

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented and include:
• Suppressor and Oncogenic Roles of TGF-

aand Its Signaling Pathways in Tumorigenesis
• Hereditary Diffuse Gastric Disease
• Role of

Overview

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented and include:
• Suppressor and Oncogenic Roles of TGF-

aand Its Signaling Pathways in Tumorigenesis
• Hereditary Diffuse Gastric Disease
• Role of Heparan Sulfate Proteoglycans in Cell Signaling and Cancer
• The Occurrence and Significance of V-Vene Mutations in B Cell-Derived Human Malignancy
• MHC Antigens and Tumor Escape from Immune Surveillance
• Foundations in Cancer Research: The Role of Selection in Progressive Neoplastic Transformation
• ATM: Genomic Stability, Neuronal Development, and Cancer Cross Paths

Product Details

ISBN-13:
9780120066834
Publisher:
Elsevier Science
Publication date:
10/28/2001
Series:
Advances in Cancer Research Series
Pages:
261
Product dimensions:
6.26(w) x 9.36(h) x 0.71(d)

Table of Contents

Insights into the Evolution of Lymphomas Induced by Epstein-Barr Virus David Vereide Bill Sugden

I EBV and its Extensive Presence in Lymphomas 2

II Tumor Cells Differ in Their Dependence on EBV 6

III A Model for EBV-Induced Lymphomagenesis 9

IV Conclusion 14

References 15

Recent Advances in the Research of Hepatitis B Virus-Related Hepatocellular Carcinoma: Epidemiologic and Molecular Biological Aspects Jia-Horng Kao Pei-Jer Chen Ding-Shinn Chen

I Introduction 22

II Factors Associated with HCC Development in Patients with Chronic HBV Infection 26

III Viral Factors in HBV-Related HCC 27

IV Nonviral Factors in HBV-Related HCC 44

V Primary Prevention of HBV-Related HCC 45

VI Molecular Carcinogenesis of HBV-Related HCC 46

VII Genetic Variations and HCC: Virus and Host Perspectives 50

VIII Conclusions 60

References 61

The ATM-Chk2 and ATR-Chk1 Pathways in DNA Damage Signaling and Cancer Joanne Smith Lye Mun Tho Naihan Xu David A. Gillespie

I Introduction 74

II Activation of the ATM-Chk2 and ATR-Chk1 DNA Pathways 75

III Checkpoint Functions of the ATM-Chk2 and ATR-Chk1 Pathways 79

IV The Three Rs of Damage Signaling: Resection, Recombination, and Repair 84

V ATM-Chk2 and ATR-Chk1 Pathway Alterations in Cancer 87

VI Exploiting Homologous Recombinational Repair (HRR) Defects for Cancer Therapy 92

VII DNA Damage Signaling as a Barrier to Tumorigenesis 95

VIII Checkpoint Suppression as a Therapeutic Principle 97

IX Future Perspectives 102

References 104

microRNAs in Cancer: From Bench to Bedside Maria Angelica Cortez Cristina Ivan Peng Zhou Xue Wu Mircea Ivan George Adrian Calin

I Introduction 114

II Alterations of miRNA Expression in Cancer 115

III Causes of miRNA Expression Variations 117

IV Pathways Involving miRNA Alterations 126

V Clinical Applications 136

VI Concluding Remarks 143

References 144

Index 159

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