Advances in Chromatographic Techniques for Therapeutic Drug Monitoring / Edition 1

Hardcover (Print)
Buy New
Buy New from
Used and New from Other Sellers
Used and New from Other Sellers
from $107.20
Usually ships in 1-2 business days
(Save 46%)
Other sellers (Hardcover)
  • All (8) from $107.20   
  • New (5) from $107.20   
  • Used (3) from $160.75   


For drugs with a narrow therapeutic index, therapeutic drug monitoring methods are essential for patient management. Although immunoassays are commercially available for many drugs and most laboratories use these assays for routine therapeutic monitoring, they have many limitations which hinder their efficacy. Providing practical guidelines for implementing preferred gas and liquid chromatographic methods, Advances in Chromatographic Techniques for Therapeutic Drug Monitoring is a comprehensive reference describing the theory and application of therapeutic drug monitoring in clinical laboratories.

Edited by a distinguished authority in the field and containing contributions from a variety of experts, the book discusses preanalytical variables, the pitfalls of immunoassays, tandem mass spectrometry, issues related to pain management and herbal supplements, and therapeutic drug monitoring for a range of medications, including:

  • Anticonvulsants
  • Digitalis
  • Cardioactive drugs
  • Antidepressants
  • Immunosuppressants
  • Anti-cancer drugs
  • Vancomycin and aminoglycosides
  • Antibiotics
  • Antiretroviral drugs
  • Nonnarcotic analgesics
  • Anti-inflammatory drugs

Examing older and newer drugs, the book contains detailed discussions on the rationale for therapeutic drug monitoring of each class of drugs, along with their basic pharmacology and toxicology. An extensive list of references is provided at the end of each chapter so that those interested in implementing a new drug assay can find the most appropriate method for the intended drug.

Read More Show Less

Editorial Reviews

From the Publisher
…This excellent book reviews not only those drugs for which chromatographic techniques have long been used, but also drugs for which therapeutic monitoring is newer (e.g., antiretroviral agents, immunosuppressive drugs, antineoplastic compounds, antidepressant drugs, analgesics, cardioactive drugs, and antibiotics). … Edited by a distinguished authority on therapeutic drug monitoring, this book should serve as both an invaluable reference for analytical toxicologists and a practical guide for laboratory physicians and scientists who are involved in the monitoring of therapeutic agents.
—From the Foreword, David N. Bailey, Vice Chancellor for Health Affairs, Dean of the School of Medicine, and Professor of Pathology & Laboratory Medicine, University of California, Irvine, USA

… a valuable reference for experienced clinical laboratory professionals, as well as an opportunity to inform a new generation of scientists and clinicians of the future potential and growing importance of clinical TDM.
—Michael Hodsdon in Future Science, May 2010, vol. 2, no. 5

Read More Show Less

Product Details

  • ISBN-13: 9781420067583
  • Publisher: CRC Press
  • Publication date: 10/6/2009
  • Edition number: 1
  • Pages: 475
  • Product dimensions: 7.20 (w) x 10.00 (h) x 1.20 (d)

Meet the Author

Dr. Amitava Dasgupta is a Professor of Pathology and Laboratory Medicine at the University of Texas Health Sciences Center at Houston. He is also the Director of Clinical Chemistry, Toxicology, and Point of Care Services at the Memorial-Hermann Hospital Laboratories at the University of Texas Medical School at Houston. He received his PhD in chemistry from Stanford University and completed his fellowship in clinical chemistry from the University of Washington at Seattle. He is certified in both clinical chemistry and toxicology by the American Board of Clinical Chemistry. Dr. Dasgupta’s major research interest is in the field of therapeutic drug monitoring and he has published 175 papers and numerous reviews and has edited four books. He is on the editorial board of American Journal of Clinical Pathology, Archives of Pathology and Laboratory Medicine, Therapeutic Drug Monitoring, Clinica Chimica Acta, and Journal of Clinical Laboratory Analysis.

Read More Show Less

Table of Contents

Introduction to Therapeutic Drug Monitoring and Chromatography, A. Dasgupta

Preanalytical Variables and Therapeutic Drug Monitoring, V. Bush

Immunoassays for Therapeutic Drug Monitoring: Pitfalls and Limitations, P. Datta and A. Dasgupta

Introduction to Tandem Mass Spectrometry, G. L. Hortin

Analytical Support of Classical Anticonvulsant Drug Monitoring beyond Immunoassay: Application of Chromatographic Methods, J. Juenke and G. McMillin

Clinical Practice of Therapeutic Drug Monitoring of New Anticonvulsants, M. D. Krasowski

Chromatographic Techniques in the Therapeutic Drug Monitoring of New Anticonvulsants, C. L. H. Snozek and L. J. Langman

Problems with Digoxin Immunoassays, A. Dasgupta

Liquid Chromatography Combined with Immunoassay as a Reference Method for Analysis of Digitalis, E. P. Womack, R. Valdes, and S. A. Jortani

Chromatographic Methods for Analysis of Cardioactive Drugs, R. W. McLawhon

Immunoassays for Tricyclic Antidepressants: Unsuitable for Therapeutic Drug Monitoring?, M. D. Krasowski, M. G. Siam, and S. Ekins

Chromatographic Techniques for the Analysis of Antidepressants, U. Garg

Pharmacokinetics and Therapeutic Drug Monitoring of Immunosuppressants, K. A. Kelly and A. W. Butch

Analysis of Immunosuppressants by Liquid Chromatography or Liquid Chromatography with Mass Spectrometry, K. N. Eaton

Therapeutic Drug Monitoring in Cancer Patients: Application of Chromatographic Techniques, A. Dasgupta

Therapeutic Drug Monitoring of Vancomycin and Aminoglycosides with Guidelines, R. Dean and A. Dasgupta

Chromatographic Methods for Analysis of Antibiotics, R. W. McLawhon

Need for Therapeutic Drug Monitoring of Antiretroviral Medications in HIV Infection, N. Y. Rakhmanina and J. N. van den Anker

Chromatographic Techniques for Therapeutic Drug Monitoring of Antiretroviral Drugs, A. Dasgupta

Chromatography in Therapeutic Drug Monitoring of Nonnarcotic Analgesics and Anti-inflammatory Drugs, U. Garg

Therapeutic Drug Monitoring in Pain Management: Application of Chromatography and Mass Spectrometry, C. L. H. Snozek and L. J. Langman

Investigation of Drug–herb Interactions: Application of various Chromatographic Techniques for Analysis of Active Components of Herbal Supplements, A. Dasgupta

Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star


4 Star


3 Star


2 Star


1 Star


Your Rating:

Your Name: Create a Pen Name or

Barnes & Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation


  • - By submitting a review, you grant to Barnes & and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Terms of Use.
  • - Barnes & reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)