Advances in Enzyme Regulation

Overview

Stepping ahead of the general front, Volume 41 in the series Advances in Enzyme Regulation moves the studies of mammalian enzymic and metabolic regulation forward.

This volume was dedicated on the centenary of his birth to Sir Hans A. Krebs who gave the Special Symposium lectures for 15 years. George Weber spoke on the joint work he carried out in Oxford with Krebs and his associates, entitled "Cancer and Clinical Targeting."

Much of the ...

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Overview

Stepping ahead of the general front, Volume 41 in the series Advances in Enzyme Regulation moves the studies of mammalian enzymic and metabolic regulation forward.

This volume was dedicated on the centenary of his birth to Sir Hans A. Krebs who gave the Special Symposium lectures for 15 years. George Weber spoke on the joint work he carried out in Oxford with Krebs and his associates, entitled "Cancer and Clinical Targeting."

Much of the Symposium centered on novel aspects of signal transduction, including Inositol Signaling and on phosphatidylinositol 3'kinase and kinase B. The Special Symposium Lecture was given on Inositol Lipid Signaling in the Nucleus.
The location and regulation of protein kinases were discussed.
Clinical aspects of enzyme regulation were presented featuring studies on dihydrophyrimidine dehydrogenase, development, citrullinemia and human melanoma heparanase.

Drug targeting and resistance were reviewed featuring etoposide and tumor vasculature. Regulation of pyruvate dehydrogenase kinase and abrogration of cytokine-dependency were analyzed. Challenging results on mRNA stability and apoptosis were presented covering cyclooxygenase-2 inhibitors, lysosomal cathepsins, human breast tumors and actin reorganization. The contents listed below provide a complete overview of topics and speakers.

AIMS AND SCOPE

This internationally acclaimed series reports progress at the cutting edge in the strategic area of regulation at the molecular level. In an integrated presentation of original papers, leading scientists, Nobel Prize winners and other outstanding experts from many countries review the best research produced each year and evaluate what is newest and what promises to be the most important in clinical and basic investigations. The volumes serve as guideposts and beacons for investigators in planning research and teaching students in basic and clinical fields of endeavour. These books advance the general front of studies on metabolic regulation and the understanding of the molecular biology of control of gene expression by hormones, drugs and growth factors in cancer cells and in clinical situations of diabetes, inborn errors of metabolism and neoplasia.

Review of Volume 33: "Careful consideration and planning have been invested in the crafting of this volume, and George Weber may feel well satisfied with the final result ...... the book succeeds in its aim to be a source of information and inspiration, and a laboratory and teaching companion.", Clinical Oncology

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Product Details

  • ISBN-13: 9780080438634
  • Publisher: Elsevier Science
  • Publication date: 2/28/2001
  • Pages: 544

Table of Contents

Acknowledgements
List of Participants
Re-examination of the Significance of Nuclear Localization of PLC[beta]1 in the Likelihood of its Involvement in Neoplastic Cell Growth 1
The Termination of PI3K Signalling by SHIP1 and SHIP2 Inositol 5-Phosphatases 15
Inhibitors of Diverse Metabolic Steps Cause Increased Apoptosis in Deoxyadenosine-Resistant Mouse Leukemia L1210 Cells That Lack p53 Expression: Convergence at Caspase-3 Activation 29
Targeting Signal Transduction 47
Utilization of the Promoter Region of the Midkine Gene as a Tool to Drive Therapeutic Genes in a Tumor Specific Manner 57
Opportunities for Studying Cancer by Metabolomics: Preliminary Observations on Tumors Deficient in Hypoxia-Inducible Factor 1 67
Structural and Mechanistic Aspects of Phosphoinositide C[gamma] Regulation 77
Phospholipase C[delta]4: From Genome Structure to Physiological Function
Activation of PI(4)P 5-Kinase by Small G Proteins 107
Importance of Phase 2 Gene Regulation in Protection against Electrophile and Reactive Oxygen Toxicity and Carcinogenesis 121
Ferritin Regulation by Oxidants and Chemopreventive Xenobiotics 135
The Regulation of Adipocyte Metabolism and Gene Expression by Interleukin-11 153
A Comprehensive Model for the Allosteric Regulation of Class Ia Ribonucleotide Reductase 167
Raf Kinases in Lung Tumor Development 183
Interaction of Cofilin with Serine Phosphatases PP1 and PP2A in Normal and Neoplastic Human T Lymphocytes 197
Regulation of Cell Survival by Atypical Protein Kinase C Isozymes 213
Regulation of Cytosolic Phospholipase A[subscript 2] Translocation 229
On the Mechanism Coupling Phospholipase C[gamma]1 to the B- and T-Cell Antigen Receptors
Interpretive Proteomics - Finding Biological Meaning in Genome and Proteome Databases 271
Clostridum Perfringens Iota-Toxin, ADP-Ribosyl-transferase: Structure and Mechanism of Action 361
Dissection of Signal-Regulated Transcriptional Modules by Signaling Pathway Interference in Oncogene-Transformed Cells 379
New Cysteine Protease Inhibitors in Physiological Secretory Fluids and their Medical Significance 393
At the Nucleus of the Problem: Nuclear Proteins and Disease 411
Author Index 445
Subject Index 457
Contents of Recent Volumes 467
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