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From The CriticsReviewer: Omer Iqbal, MD, FACC, FESC (Loyola University Medical Center)
Description: This valuable resource on the biochemical basis of antibiotic resistance discusses recent concepts of resistance related to a complex series of multidrug efflux transporters and multidrug efflux pumps, most importantly the resistance-nodulation-division (RND) family of bacterial efflux pumps.
Purpose: Because of the extraordinary importance of antibiotic resistance in modern medicine, this book is the first of a series on recent advances in the biochemical basis of antibiotic resistance.
Audience: It is written for students and researchers in molecular biology, biochemistry, and enzymology as well as scientists interested in the discovery of an enzyme, its properties, and its applications. In my opinion, even clinicians specializing in infectious diseases would find this book of immense help.
Features: Each of the seven chapters is written by noted experts. The first chapter covers the structure and mechanism of RND-type multidrug efflux pumps considered to be the most important phenomenon of bacterial resistance, which the second chapter concentrates on the inducers of RND efflux pump activation and inhibitors of bacterial efflux pumps serving as multilevel controls. The third chapter details current concepts of the structure of tripartite RND transporters vital to the pathogenicity of important human pathogens such as Escherichia coli, Campylobacter, and Neisseria. The fourth chapter covers the largest and structurally most diverse group of secondary membrane transport proteins, the major facilitator superfamily (MFS) group, and its role in the pathogenicity of gram-positive and gram-negative bacteria, while the fifth chapter discusses efflux pumps as an important mechanism for quinolone resistance. The sixth chapter is a genomic update on xenobiotic efflux in bacteria and fungi. The last chapter provides a survey of oxidative paracatalytic reactions catalyzed by enzymes that generate carbanionic intermediates and the implications for ROS production, cancer etiology, and neurodegenerative diseases. The book is well illustrated with both black-and-white and color illustrations.
Assessment: With its discussion of current concepts of the biochemical basis of antibiotic resistance and its impact on modern medicine, this book will appeal to students, researchers, scientists, and clinicians interested in the areas of enzymology and mechanism of bacterial resistance.