Advances in Enzymology and Related Areas of Molecular Biology, Mechanism of Enzyme Action / Edition 1

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Overview

Biological catalysis plays a dominant role both in fermentation and industrial process chemistry. This collection of chapters, written by a well-known biochemist and enzymologist, should serve as an invaluable reference to those investigators seeking to optimize the application of enzymatic catalysis for commercial purposes.

The book contains predominantly black-and-white illustrations, with some color illustrations.

Biological catalysis plays a dominant role both in fermentation and industrial process chemistry. This collection of chapters, written by a well-known biochemist and enzymologist, should serve as an invaluable reference to those investigators seeking to optimize the application of enzymatic catalysis for commercial purposes.

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Editorial Reviews

Doody's Review Service
Reviewer: Eugene A Davidson, PhD (Georgetown University School of Medicine)
Description: This is the latest volume in a well established series covering various topics in enzymology.
Purpose: The purpose is to provide information to investigators seeking to optimize the application of enzymatic catalysis for commercial purposes.
Audience: The articles are somewhat limited in scope and will appeal only to investigators in the direct areas covered.
Features: In the initial article, new interpretations of kinetic data are discussed, using mathematical tools based on the classic Michaelis-Menten equation. A key enzyme in purine biosynthesis, adenylosuccinate synthase, is analyzed in terms of recent x-ray data. Additional chapters cover nucleoside kinases, NAD synthesis, pyrophosphate hydrolysis, and aspects of glutathione biosynthesis. A nostalgic addition is the inclusion of a paper originally published by Britton Chance in 1943 on rapid reaction kinetics.
Assessment: The quality of the articles is high, although the failure to impose a generally accepted citation format (i.e., complete titles and pagination) is a drawback. I commend the inclusion of the Chance paper since it serves to remind the reader of the important contributions made in this area before the advent of crystallography, recombinant protein production, and heavy automation.
Eugene A. Davidson
This is the latest volume in a well established series covering various topics in enzymology. The purpose is to provide information to investigators seeking to optimize the application of enzymatic catalysis for commercial purposes. The articles are somewhat limited in scope and will appeal only to investigators in the direct areas covered. In the initial article, new interpretations of kinetic data are discussed, using mathematical tools based on the classic Michaelis-Menten equation. A key enzyme in purine biosynthesis, adenylosuccinate synthase, is analyzed in terms of recent x-ray data. Additional chapters cover nucleoside kinases, NAD synthesis, pyrophosphate hydrolysis, and aspects of glutathione biosynthesis. A nostalgic addition is the inclusion of a paper originally published by Britton Chance in 1943 on rapid reaction kinetics. The quality of the articles is high, although the failure to impose a generally accepted citation format (i.e., complete titles and pagination) is a drawback. I commend the inclusion of the Chance paper since it serves to remind the reader of the important contributions made in this area before the advent of crystallography, recombinant protein production, and heavy automation.
Booknews
Describes mechanistic inquiries of enzyme catalysis. Authors have been requested to concentrate on work achieved in their laboratory, allowing sufficient opportunity to divulge the hypotheses and scaffolding of logic that led them to new insights on the action of a particular enzyme. Topics include nucleoside monophosphate kinases, enzymes of glutathione synthesis, enzymology of NAD+ synthesis, and mechanism of MuT pyrophosphohydrolase. Of interest to researchers in the molecular life sciences, as well as enzymologists, pharmacologists, and medicinal chemists. Annotation c. Book News, Inc., Portland, OR (booknews.com)

2 Stars from Doody
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Product Details

Table of Contents

Classics in Enzymology: The Kinetics of the Enzyme-Substrate Compound of Peroxidase (B. Chance).

Rethinking Fundamentals of Enzyme Action (D. Northrop).

Adenylosuccinate Synthetase: Recent Developments (R. Honzatko, et al.).

Nucleoside Monophosphate Kinases: Structure, Mechanism, and Substrate Specificity (H. Yan & M.-D. Tsai).

Enzymology of NAD?+ Synthesis (G. Magni, et al.).

Solution Structure and Mechanism of MutT Pyrophosphohydrolase ( A. Mildvan, et al.).

The Enzymes of Glutathione Synthesis: gamma-Glutamylcysteine Synthetase (O. Griffith & R. Mulcahy).

Indexes.

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