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From The CriticsReviewer: Eugene A Davidson, PhD (Georgetown University School of Medicine)
Description: This is the latest volume in a well established series covering various topics in enzymology.
Purpose: The purpose is to provide information to investigators seeking to optimize the application of enzymatic catalysis for commercial purposes.
Audience: The articles are somewhat limited in scope and will appeal only to investigators in the direct areas covered.
Features: In the initial article, new interpretations of kinetic data are discussed, using mathematical tools based on the classic Michaelis-Menten equation. A key enzyme in purine biosynthesis, adenylosuccinate synthase, is analyzed in terms of recent x-ray data. Additional chapters cover nucleoside kinases, NAD synthesis, pyrophosphate hydrolysis, and aspects of glutathione biosynthesis. A nostalgic addition is the inclusion of a paper originally published by Britton Chance in 1943 on rapid reaction kinetics.
Assessment: The quality of the articles is high, although the failure to impose a generally accepted citation format (i.e., complete titles and pagination) is a drawback. I commend the inclusion of the Chance paper since it serves to remind the reader of the important contributions made in this area before the advent of crystallography, recombinant protein production, and heavy automation.