Advances in Hematopoietic Stem Cell Transplantation and Molecular Therapy / Edition 1

by Rainer Haas, Ralf Kronenwett, Georg Sczakiel

Overview

Blood stem cell transplantation has become an established therapeutic option in the treatment of malignant diseases. At the same time molecular therapeutic approaches (i.e. gene therapy) are promising alternatives to the classical treatment of cancer. The proceedings give an overview of the biology of hematopoietic progenitor cells, peripheral stem cell transplantation in patients with hematological malignancies, recent developments in molecular diagnosis and gene therapeutic concepts, and show that successful future developments require cooperative research connecting basic science with clinical application.

Product Details

ISBN-13:	9783642468384
Publisher:	Springer Berlin Heidelberg
Publication date:	04/04/2012
Series:	Recent Results in Cancer Research , #144
Edition description:	Softcover reprint of the original 1st ed. 1998
Pages:	150
Product dimensions:	6.10(w) x 9.25(h) x 0.01(d)

About the Author

Haas, Rainer (Univ of Heidelberg); Kronenwett, Ralf (German Cancer Research Centre); Sczakiel, Georg (Univ of Heidelberg)

The contributors represent the specialties of internal medicine, hematology and oncology, pathology, immunology, and medical genetics. Most are from universities, hospitals, and research institutes in Germany, Italy, France, the U.S., Canada, Scotland, and the U.K. Institutions prominently represented include Univ of Heidelberg, Univ of Oxford, and German Cancer Research Center-Heidelberg.

Table of Contents

Mobilization and Selection of CD34+Cells.- Autologous Stem Cell Transplantation for Chronic Myeloid Leukemia.- Autologous Stem Cell Transplantation.- Peripheral Blood Progenitor Cell Transplantation.- Molecular Monitoring of Residual Disease.- Delineation of Genomic Regions in Chromosome Band 7q22 Commonly Deleted in Myeloid Leukemias.- Molecular Cytogenic Analysis of Low-Grade B-Cell Neoplasias: A Comparative Genomic Hybridization Study.- Applications of Gene Transfer in Hematologic Malignancy.- Dendritic Cells for Somatic Gene Therapy.- Construction of Immunogenetic Tumor Cell Surfaces by Somatic Gene Transfer.- Adeno-associated Virus Type 2 Vector for Transduction of Hematopoietic Cells.- Protection of Hematopoietic Stem Cells from Chemotherapy-Induced Toxicity by Multidrug-Resistance 1 Gene Transfer.- Regulated Gene Expression After Retroviral Vector-Mediated Delivery of Cancer-Relevant Therapeutic Genes.- Specific bcr-abl Directed Antisense Nucleic Acids and Ribozymes: A Tool for The Treatment of Chronic Myelogenous Leukemia?.- The Use of Ribozymes in Gene Therapy Approaches to AIDS.- Subject Index.-