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Advances in Immunology

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Advances in Immunology presents current developments as well as comprehensive reviews in immunology. Articles in this volume address topics such as protein degradation and the generation of MHC class I-presented peptides, proteolysis and antigen presentation by MHC Class II molecules, cytokine memory of T-helper lymphocytes, Ig gene hypermutation, generalization of single immunological experiences by idiotypically mediated clonal connections, and aging of the immune system. Edited and authored by the foremost ...
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Overview

Advances in Immunology presents current developments as well as comprehensive reviews in immunology. Articles in this volume address topics such as protein degradation and the generation of MHC class I-presented peptides, proteolysis and antigen presentation by MHC Class II molecules, cytokine memory of T-helper lymphocytes, Ig gene hypermutation, generalization of single immunological experiences by idiotypically mediated clonal connections, and aging of the immune system. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

Audience: Immunologists, infectious disease researchers, and hematologists.

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Editorial Reviews

John A. Robinson
This is a serial collection of monographs on controversial or new important developments in immunology. Whenever an immunologist has a pressing need to "get educated" on a specific topic, the hope is fervent that the area of interest has been selected for publication in a recent Advances. If it has, the hunt has ended, because here is the source that provides all the new and old data, new perspectives, conflicting questions, and current and comprehensive citation lists! It would appeal to both basic and clinical immunologists. The editors have been careful to select writers for each topic that are experts in the field of interest and write with clarity. This is an essential component in all immunology libraries.
From The Critics
Reviewer: Marion C. Cohen, PhD(SUNY Downstate Medical Center)
Description: This is a volume in Advances in Immunology, a series of well regarded reviews on contemporary issues in immunology. Each volume consists of five to eight reviews that are usually on topics not related to one another but are on matters of current interest. These reviews are generally very detailed with extensive reference lists.
Purpose: There is no preface or introduction to the book but one could well argue that this series is so well known that none is necessary. One can only assume that the purpose of each review is to provide a detailed look at the background as well as the current information available on a particular topic. This goal is generally met.
Audience: The book seems to be intended primarily for researchers both at the beginning and advanced levels. Each volume in the series provides background information that is useful for anyone who needs to know more about a particular topic. The editor and associate editors are highly regarded immunologists and the contributors of the individual chapters are experts in the areas about which they are writing.
Features: In this volume, as in the others, a wide variety of topics is covered. Some are broad such as a chapter on mouse models of allergic airways disease while others, although detailed, are more focused. An example of the latter is a chapter on the role of Btk and BLNK in B cell development. A nice feature is the use of subheadings so that one can more easily access specific information. An extensive reference list is provided for each chapter. These are as up-to-date as possible given the fact that information for any important contemporary topic is constantly expanding. There is an index but since the subjects of each chapter vary, its utility is somewhat limited.
Assessment: This volume represents a format that has worked well for many years. The reviews are always useful and detailed with excellent reference sections. Although the number of review articles or journals devoted to reviews is increasing, the reviews found in this book are remarkably lengthy and detailed. They continue to provide an excellent source of information.
Booknews
Volume 44 in this highly respected series considers: diversity of the immunoglobulin gene superfamily, genetically engineered antibody molecules, antinuclear antibodies, interleukin-1 and its biologically related cytokines, molecular and cellular events of T cell development, molecular biology and function of CD4 and CD8, lymphocyte homing. Annotation c. Book News, Inc., Portland, OR (booknews.com)
From the Publisher
PRAISE FOR THE SERIES
"The series which all immunologists need."
—THE PHARMACEUTICAL JOURNAL
"Advances in Immunology must find itself among the most active volumes in the libraries of our universities and institutions."
—SCIENCE
"Deserves a permanent place in biomedical libraries as an aid in research and in teaching."
—JOURNAL OF IMMUNOLOGICAL METHODS
"A provocative and scholarly review of research."
—JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
"Provides an extremely valuable source of reference and many stimulating ideas...the main repository of information in a rapidly developing subject."
—THE LANCET
"Provides unrivaled value in both academic and fiscal terms and should be purchased by hard pressed librarians as a major priority to be jealously defended."
—JOURNAL OF MEDICAL MICROBIOLOGY
"A very valuable serial publication...no serious student of immunology can afford to be without it."
—ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

3 Stars from Doody
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Product Details

  • ISBN-13: 9780120224401
  • Publisher: Elsevier Science & Technology Books
  • Publication date: 5/28/1987
  • Series: Serial Publication Ser.
  • Pages: 456

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A Leader in Immunology
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Table of Contents

Contributors
Protein Degradation and the Generation of MHC Class I-Presented Peptides
Protein Degradation 2
Antigen Presentation 21
Proteolysis and Antigen Presentation by MHC Class II Molecules
Protease Activity in Antigen-Presenting Cells 73
Proteolytic Digestion of Ii 87
Proteolytic Control of Vesicle Biogenesis and Class II Trafficking through the Endocytic Pathway 92
The Role of Ii in Regulating the Proteolytic Activities of APCs 94
Antigen Processing 96
Cytokine Memore of T Helper Lymphocytes
Cytokine Signals in the Induction of T Cell Cytokine Memore 117
Key Transcription Factors in the Induction and Maintenance of Cytokine Memory 122
Role of the Antigen-Presenting Cell in the Induction of Cytokine Memory 130
T Cell Receptor Signals in the Induction of Cytokine Memory 133
Epigenetic Modifications of Cytokine Genes 138
Stability and Plasticity of Cytokine Memory 145
Cytokine Memory as Part of T Cell Differentiation Programs 149
Cytokine Memory of Memory T Cells 154
Ig Gene Hypermutation: A Mechanism Is Due
Mismatch Repair 183
The "Nickase" 186
The Role of Transcription 187
Hypermutation Is Generated by a DNA Polymerase 188
Error-Prone DNA Polymerases 191
More DNA Polymerases 194
Targeting to Non-Ig Genes 195
AID 195
Generalization of Single Immunological Experiences by Idiotypically Mediated Clonal Connections
Idiotypic Transformation of Single Immunological Experiences in the Adult 204
Transfer of Maternal Immunological Experience to the Offspring 223
The Aging of the Immune System
The Biological Aging Process 243
The Aging of the Immune System 248
The Consequences of Immune Senescence 263
Modes of Intervention 268
Index 285
Contents of Recent Volumes 293
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