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This volume provides an in-depth view on the current state of research and clinical application of intravenous anaesthesia. It is divided into three sections with subjects on pharmacokinetic and dynamic modelling of anaesthetic action, monitoring and clinical application of intravenous anaesthesia and on the determination and meaning of effect sites of anaesthetic action. This volume is of great interest and education value to all professionals in the science of clinical application of intravenous anaesthesia.
Pharmacokinetic and Dynamic Modelling. 1. Basic Pharmacokinetics Principles for Intravenous Anaesthesia; F. Engbers. 2. Basic Concepts of Recirculatory Pharmacokinetic Modelling; M. Reekers, F. Boer, J. Vuyk. 3. Recirculatory Pharmacokinetics. Which Covariates Affect the Pharmacokinetics of Intravenous Anaesthetics? T. Henthorn. 4. Modelling of Drug Interactions; C. Minto, J. Vuyk. 5. Age Related Changes of PK/PD of Intravenous Anaesthetics; T. Schnider. 6. The Clinical Application of Pharmacokinetic and Dynamic Models; V. Billard. 7. Gender Differences in Morphine Pharmacokinetics and Respiratory Dynamics; E. Sarton, R. Romberg, A. Dahan. 8. Influence of Intravenous Anaethetics on the Control of Breathing; A. Dahan, D. Nieuwenhuis, E. Olofsen.
Monitoring and Clinical Application of Intravenous Anaesthesia. 9. Bispectral Index Monitoring and Intravenous Anaesthesia; J. Vuyk, M. Mertens. 10. Auditory Evoked Potential Monitoring as Research and Clinical Tool; S. Schraag, G. Kenny. 11. PET-Scanning of Anaesthetic Action; P. Fiset. 12. The Development and Future Of TCI; I. Glen. 13. Awareness 1960 - 2002, Explicit Recall of Events during General Anaesthesia; R. Sandin. 14. Sedation for Locoregional Anaesthesia; A. Holas. 15. Target Controlled Infusion in Children; X. Viviand. 16. Remifentamil for Cardiac Surgery; L. Barvais, N. Sutcliffe.
Effect Sites Of Analgesic And Anaesthetic Action. 17. The NMDA-Receptor: Beyond Anaesthetic Action; F. Sureda, J. Mallol. 18. Pharmacology and Clinical Action Of COX-2 Selective Inhibitors; J. Bovill. 19. Neuromodulatory Action of the Endocannabinoids; L. de Petrocellis, T. Bisogno, V. di Marzo. 20. Effect Sites of Neuromuscular Blocking Agents and the Monitoring of Clinical Muscle Relaxation; C. Meistelman. 21. Effect Site Modelling and its Application in TCI; E. Mortier, M. Struys. 22. Remifentanil: from Pharmacological Properties to Clinical Practice; F. Servin. 23. Advances in Regional Anaesthesia and Analgesia; A. Borgeat, G. Ekatodramis. 24. Ketamine, Revival of a Versatile Intravenous Anaesthetic; J. Raeder.