Advances in Ocular Toxicology / Edition 1

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Editorial Reviews

Doody's Review Service
Reviewer: John W. Chandler, MD, FACS (University of Washington School of Medicine)
Description: This is a compendium of the presentations, discussions, and workshops of the Fifth Congress of the International Society of Ocular Toxicology held in late 1996.
Purpose: The editors and organizers arranged the meeting around themes including ocular drug metabolism, the ocular pathophysiological effects of nitric oxide, regulatory issues related to alternative methods of toxicity testing, and a workshop on alternative in vivo and in vitro toxicity testing. The subject matter is important and the papers are informative.
Audience: The book's contents are of interest to ocular toxicologists, pharmaceutical industry professionals, and regulatory officials. The contributors are leaders in these groups.
Features: The book is primarily composed of text and figures. The references in most of the articles are current and pertinent. The discussions are compiled from tape recordings at the meeting and are a positive addition to the book.
Assessment: For persons with an interest in any aspect of ocular toxicology or pharmacology, this book is a useful source of information.
John W. Chandler
This is a compendium of the presentations, discussions, and workshops of the Fifth Congress of the International Society of Ocular Toxicology held in late 1996. The editors and organizers arranged the meeting around themes including ocular drug metabolism, the ocular pathophysiological effects of nitric oxide, regulatory issues related to alternative methods of toxicity testing, and a workshop on alternative in vivo and in vitro toxicity testing. The subject matter is important and the papers are informative. The book's contents are of interest to ocular toxicologists, pharmaceutical industry professionals, and regulatory officials. The contributors are leaders in these groups. The book is primarily composed of text and figures. The references in most of the articles are current and pertinent. The discussions are compiled from tape recordings at the meeting and are a positive addition to the book. For persons with an interest in any aspect of ocular toxicology or pharmacology, this book is a useful source of information.
Booknews
Developed around the themes of ocular drug metabolism, the ocular pathophysiological effects of nitric oxide, and government issues relating to the use of alternative methods for toxicity testing. A workshop also compared in-vitro with in-vivo models and different animal models. Among the 24 specific topics are the role in inflammation of cytochrome P450 and arachidonic acid metabolism in the corneal epithelium, a possible explanation and preventive measures for corneal damage following continuous infusion in rats, a preliminary report on the barotoxic effects on morphology and the viability of trabecular cells, the experimental implantation of devices for electrical retinal stimulation in rabbits, and characterizing immortalized lens epithelial cells as a potential in-vitro alternative model for the cellular toxicity and the efficacy evaluations of ocular drug candidates. Annotation c. by Book News, Inc., Portland, Or.

3 Stars from Doody
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Product Details

  • ISBN-13: 9780306456145
  • Publisher: Springer US
  • Publication date: 5/28/1997
  • Series: The Language of Science Series
  • Edition description: 1997
  • Edition number: 1
  • Pages: 276

Table of Contents

Welcome and Opening of Congress 1
1 Cytochrome P450 and Arachidonic Acid Metabolism in the Corneal Epithelium: Role in Inflammation 3
2 The Effects of 12(R)HETE and Its Metabolite 8(R)HHDTrE on Corneal Endothelial Function 21
3 Protein-Thiol Mixed Disulfides and Thioltransferase in the Lens: A Review 27
4 Corneal Lesions in Beagle Dogs Given Oral 5-Ethynyluracil Followed by 5-Fluorouracil 47
5 Corneal Damage following Continuous Infusion in Rats: Possible Explanation and Preventative Measures 55
6 Ultraviolet Light-Induced Damage in Rabbit Corneal Epithelial Cells in Vitro: Protection with Absorption Filters 63
7 The Effects of ad Libitum (AL) Overfeeding and Moderate Dietary Restriction (DR) on the Incidence of Spontaneous Corneal Dystrophy in Control Sprague-Dawley (SD) Rats 73
8 Barotoxic Effects on Morphology and Viability of Trabecular Cells: A Preliminary Report 81
9 Topical Fluorescein Application Can Induce Iritis and Glaucoma: An Unusual Case Report 87
10 Ocular Toxicity of Sodium Diethylthiocarbamate, DDTC, in the Beagle Dog 93
11 Do Therapeutic Doses of Ethambutol Cause Optic Nerve Toxicity? 97
12 Testing of Ocular Viscoelastics by Injection into the Rabbit Vitreous: Historical Control Data Resulting from Various Dosing Techniques 103
13 Effects of Antiviral Agents on Retinal Function in Vertebrate Retina 107
14 Experimental Implantation of Devices for Electrical Retinal Stimulation in Rabbits: Preliminary Results 113
15 Nitric Oxide in Ocular Inflammation 121
16 Role of Nitric Oxide in Vascular Dysfunction Associated with Ocular Diseases 133
17 Effects of the Inhibition of Nitric Oxide Synthase and Lipoxygenase on the Development of Endotoxin-Induced Uveitis 151
18 Evaluation of Two Rabbit Ocular Implantation Models Using Polymethylmethacrylate Intraocular Lenses 159
19 Characterization of Immortalized Lens Epithelial Cells as a Potential in Vitro Alternative Model for the Cellular Toxicity and the Efficacy Evaluations of Ocular Drug Candidates 169
20 Immortalization and Characterizations of Rabbit Corneal Epithelial Cell Lines as Potential in Vitro Alternative Models for Evaluating the Cellular Toxicity of Ocular Drug Candidates 181
21 Comparison of Some in Vitro Measurements of Membrane Damage to Corneal Epithelial Cells 193
22 Computer-Assisted Evaluation of Iris Color Changes in Primate Toxicity Studies 203
23 Workshop on in Vitro versus in Vivo Models for Ocular Toxicity Testing 207
24 Toxicity Testing for Ocular Drug Products 261
Participants 269
Index 273
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