Adverse Drug Interactions: A Handbook for Prescribers

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Overview

This handy, portable book provides information on potential adverse effects when prescribing two or more drugs for simultaneous use, organised by drug class in a convenient, user-friendly format. Interactions that are likely to give rise to life-threatening conditions and which must therefore be completely avoided are clearly highlighted. Less threatening, but nonetheless important, interactions necessitating practical measures such as frequent monitoring and advice to patients are also detailed.

Presented in tabular form for ease of reference, the book also provides a brief summary of the mechanism underlying a particular interaction, alternative drugs lacking the same reactions that may be considered, and instructions for monitoring patients when adverse affects occur.

This book is an essential companion for the physician, nurse prescriber and pharmacist in the clinical setting and an invaluable reference for medical students.

  • Portable guide covering all major drug groups
  • At-a-glance tabular format
  • Use of complex pharmacological terminology minimised for the non-specialist
  • All advice supported by appropriate evidence
  • Also includes potential interactions with over the counter medications, herbal remedies, dietary supplements, food, and alcohol
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Editorial Reviews

From the Publisher
There are not many comprehensive books that address this common problem [adverse drug interactions] and as one of the early works, this is an excellent start. This is valuable as a desk reference for every clinician's desk and for every hospital nursing station.
Doody's Review Service
Doody's Review Service
Reviewer: Vincent F Carr, DO, MSA, FACC, FACP (Uniformed Services University of the Health Sciences)
Description: This book uses a tabular format to depict the interactions that may occur when prescribing a number of different medications.
Purpose: The authors note the number of hospitalizations and deaths that occur annually because of drug interactions and medication overdosages as their reason for providing this excellent, concise reference. Clearly, a book such as this is needed, and the authors have developed a format that is easy to use.
Audience: This would be valuable for all clinicians. To their credit, the authors have generally stayed with generic medicine names to avoid the confounding problems of referring to trade or proprietary medication names. This decision makes the book useful to both U.K. and U.S. clinicians.
Features: The format is primarily tabular, with sections based upon general usage categories, e.g. anticancer and immunomodulating drugs; anticoagulants; antidiabetic drugs; etc. This is a very useful delineation that I found very easy to use, based upon what I intended to prescribe. At the beginning of each section, there are some general considerations regarding the class of medications, but not to the depth where it becomes tedious. The tables are the meat of the book.
Assessment: There are not many comprehensive books that address this common problem and as one of the early works, this is an excellent start. This is valuable as a desk reference for every clinician's desk and for every hospital nursing station.
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Product Details

  • ISBN-13: 9780340927694
  • Publisher: Taylor & Francis
  • Publication date: 3/15/2009
  • Series: A Hodder Arnold Publication Series
  • Pages: 849
  • Product dimensions: 5.10 (w) x 7.70 (h) x 1.20 (d)

Meet the Author

Lakshman Karalliedde DA FRCA
Visiting Senior Lecturer, Department of Public Health Sciences, King's College London School of Medicine;
Consultant Medical Toxicologist, Health Protection Agency, London, UK

Simon F. J. Clarke DA FRCS(Ed) FCEM
Consultant Emergency Medicine Physician,
Frimley Park NHS Foundation Trust, UK;
Honorary Consultant Medical Toxicologist,
Chemical Hazards and Poisons Division (London),
Health Protection Agency, UK

Ursula Collignon BPharm MRPharmS
Senior Pharmacist, Guy's & St Thomas' NHS Foundation Trust
London, UK

Janaka Karalliedde MBBS MRCP
Clinical Lecturer in Diabetes and Endocrinology, King's College London School of Medicine, King's College London, UK

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Table of Contents

Cardiovascular drugs
Introduction
Aliskiren
Antiarrhythmics
Antihypertensives and heart failure drugs
Antiplatelet drugs
Beta-blockers
Calcium channel blockers
Cardiac glycosides
Diuretics
Ivabradine
Lipid-lowering drugs
Nitrates
Peripheral vasodilators
Potassium channel activators
Selective phosphodiesterase inhibitors
Sympathomimetics

Drugs acting on the nervous system
Introduction
Antidementia drugs
Antidepressants
Antiemetics
Antiepileptics
Antimigraine drugs
Antiobesity drugs
Antiparkinson's drugs
Antipsychotics
Anxiolytics and hypnotics
CNS stimulants
Drug dependence therapies
Drugs used to treat neuromuscular diseases and movement disorders

Anticancer and immunomodulating drugs
Introduction
Cytotoxics
Hormones and hormone antagonists
Other immunomodulating drugs

Anticoagulants
Introduction
Anticoagulants - oral
Anticoagulants - parenteral
Thrombolytics

Anitdiabetic drugs
Introduction
Insulin
Metformin
Sulphorylureas
Other diabetic drugs

Other endocrine drugs
Bisphosphonates
Danazol
Desmopressin
Diazoxide
Dutasteride
Female sex hormones
Gestrinone
Glucagon
Nandrolone
Somatropin (growth hormone)
Steroid replacement therapy
Strontium ranelate
Testosterone
Thyroid hormones
Trilostane

Analgesics
Introduction
Acetaminophen
Nefopam
Non-steroidal anti-inflammatory drugs (NSAIDs)
Opioids
Paracetamol

Muscoskeletal drugs
Introduction
Antigout drugs
Drugs treating inflammatory arthropathies
Drugs affecting bone metabolism
Skeletal muscle relaxants

Anaesthetic drugs
Introduction
Anaesthetics - general
Anaesthetics - local
Anticholinesterases
Antimuscarinics
Benzodiazepines
Dantrolene
Muscle relaxants - depolarizing and non-depolarizing
Opioids

Drugs to treat infections
Introduction
Antibiotics - aminoglycosides
Antibiotics - beta-lactams
Antibiotics - macrolides
Antibiotics - penicillins
Antibiotics - quinolones
Antibiotics - rifamycins
Antibiotics - sulphonamides
Antibiotics - tetracyclines
Other antibiotics
Antifungal drugs
Antimalarials
Other antiprotozoals
Antivirals - antiretrovirals
Antivirals - other

Drugs acting on the gastrointestinal tract
Introduction
Antacids
Antidiarrhaeals
Antiemetics
Antimuscarinics
Drugs affecting bile
Drugs used to treat inflammatory bowel disease
H2 receptor blockers
Pancreatin
Proton pump inhibitors
Sucralfate
Tripotassium dicitratobismuthate

Respiratory drugs
Introduction
Antihistamines
Bronchodilators
Doxapram
Leukotriene receptor antagonists

Metabolic drugs
Agalsidase
Laronidase
Penicillamine
Sodium phenylbutyrate
Trientine

Drugs used in obstetrics and gynaecology
Danazol
Ergometrine
Female hormones
Gestrinone
Mifepristone
Oxytocics
Prostaglandins
Raloxifene
Tibolone

Urological drugs
Urinary retention
Urinary incontinence
Erectile dysfunction
Urinary alkalization

Drugs of abuse
Cannabis
Amphetamines
Ecstasy (MDMA)
Cocaine
Heroin
Hallucinogens
Gamma hydroxybutyric acid

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