After Dolly: The Uses and Misuses of Human Cloning

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A brave, moral argument for cloning and its power to fight disease.

A timely investigation into the ethics, history, and potential of human cloning from Professor Ian Wilmut, who shocked scientists, ethicists, and the public in 1997 when his team unveiled Dolly—that very special sheep who was cloned from a mammary cell. With award-winning science journalist Roger Highfield, Wilmut explains how Dolly launched a medical revolution in which ...
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More About This Book

Overview

A brave, moral argument for cloning and its power to fight disease.

A timely investigation into the ethics, history, and potential of human cloning from Professor Ian Wilmut, who shocked scientists, ethicists, and the public in 1997 when his team unveiled Dolly—that very special sheep who was cloned from a mammary cell. With award-winning science journalist Roger Highfield, Wilmut explains how Dolly launched a medical revolution in which cloning is now used to make stem cells that promise effective treatments for many major illnesses. Dolly's birth also unleashed an avalanche of speculation about the eventuality of cloning babies, which Wilmut strongly opposes. However, he does believe that scientists should one day be allowed to combine the cloning of human embryos with genetic modification to free families from serious hereditary disease. In effect, he is proposing the creation of genetically altered humans. 20 illustrations.
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Editorial Reviews

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Dolly, the most renowned wooly creature in history, owes her fame and indeed her existence to Ian Wilmut's scientific team, who cloned her in 1996. The breakthrough not only made Dolly the world's most celebrated sheep; it also unleashed reams of media debates about the ethics and possibilities of cloning. Now Wilmut and Daily Telegraph science editor Roger Highfield tackle questions even more complicated than those asked then, including the very plausible creation of genetically altered humans. Their book is sure to rekindle the flames of controversy.
Publishers Weekly
In 1997 the world was surprised to learn that scientists had cloned the first mammal, a sheep named Dolly. The lead scientist for the project, carried out at the Roslin Institute in Scotland, was Ian Wilmut, who in this engrossing book tells how he and his colleagues made their breakthrough. Many people were excited about the potential medical advances that cloning presented; others were convinced it was a step toward eugenics and human cloning. Wilmut, assisted by Highfield, science editor of Britain's Daily Telegraph, argues passionately that cloning will revolutionize medicine and-perhaps a little too optimistically after the South Korean cloning scandal-that scientists can be relied on to behave. He explains why a blastocyst, the 200 cells present a few days after fertilization, is not an embryo and should be permitted in medical research. But Wilmut opposes the use of genetic enhancement to create "designer babies." The author is a bit defensive at times, but he explains his positions clearly so readers on both sides of this contentious issue will be able to re-examine and clarify their own convictions. 20 b&w illus. (June 12) Copyright 2006 Reed Business Information.
Library Journal
In a useful follow-up to his The Second Creation: Dolly and the Age of Biological Control, coauthored with Keith Campbell and Colin Tudge, Wilmut, the Scottish scientist who unveiled Dolly the cloned sheep, and science writer Highfield survey the complex, interdisciplinary, and still evolving science of therapeutic cloning, including addressing the recent South Korean stem cell fraud scandal. Despite the furor over Dolly, lessons learned in the years since show that even genetically identical sheep have distinct physiologies and personalities. In addition, the social and medical implications of the work building on Dolly's legacy have profound implications, not yet fully understood or appreciated, although in the authors' opinion, replacing deceased children or pets with "identical" clones isn't going to happen. In addition, Wilmut provides useful glimpses of the attractions, challenges, and frustrations of scientific careers. Recommended for all science collections, as we all need to try to keep up with these complex and important issues. [See Prepub Alert, LJ 2/1/06.] Mary Chitty, Cambridge Healthtech Inst., Newton, MA Copyright 2006 Reed Business Information.
Kirkus Reviews
This book from the "father" of the world's first cloned animal ranges from autobiography to medical history to an extensive discussion of the policies and ethical issues raised by Dolly. An undistinguished student when he arrived at agricultural college, Wilmut became fascinated there with embryology. He landed a summer job at an animal research station, supervised by leaders in reproductive science. That launched him into decades of work: freezing and thawing embryos; inserting genes to get animals to express useful drugs ("pharming"); and finally producing Dolly. Assisted by Daily Telegraph science editor Highfield, Wilmut graphically describes the process of transferring DNA from a mammary-gland cell of an adult ewe to an egg denuded of its nucleus, then implanting the embryo into a surrogate sheep; these pages are among the book's high points. But no one should conclude that "now we can do it so much better and faster," the authors aver. Although now more common, cloning is still a daunting process. Wasted eggs, failed pregnancies and deformed offspring reveal how complex and subtle are the steps in reproduction. For these reasons, Wilmut concludes that human cloning is not only unethical, but also impractical. He argues instead for creating blastocysts, the hollow, days-old spheres of cells lined with embryonic stem cells. These would make it possible, for example, to study hereditary diseases, to test treatments for them, maybe even to correct the defects that cause them. "A blastocyst is not a person," the authors passionately contend. They hope that gradual growth in knowledge, the generation of useful applications and sheer familiarity with the science (here they make an aptcomparison with in vitro fertilization technology) might bring around the naysayers, especially if strict regulation assures the highest ethical standards. The how of cloning, beautifully told by optimists who believe that wise heads and good science will justify the whys.
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Product Details

  • ISBN-13: 9780393060669
  • Publisher: W W Norton & Co Inc
  • Publication date: 6/12/2006
  • Edition description: 1ST
  • Pages: 256
  • Product dimensions: 5.80 (w) x 8.30 (h) x 1.20 (d)

Meet the Author

Ian Wilmut, formerly of the Roslin Institute in Scotland where Dolly was cloned, is now a professor at the University of Edinburgh and has given evidence and testimony to governmental agencies, Congress, and the United Nations. Roger Highfield is the science editor of The Daily Telegraph in Britain and the author of several books.
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Table of Contents

1 Cloning the cloner 36
2 A brief history of cloning 58
3 Dollymania 102
4 Farmyard clones 137
5 Cloning for my father 162
6 Is a blastocyst a person? 198
7 Why we should not clone babies 223
8 Designer babies 249
9 Beyond human cloning 272
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