Against Depression [NOOK Book]


In his landmark bestseller Listening to Prozac, Peter Kramer revolutionized the way we think about antidepressants and the culture in which they are so widely used. Now Kramer offers a frank and unflinching look at the condition those medications treat: depression. Definitively refuting our notions of "heroic melancholy," he walks readers through groundbreaking new research—studies that confirm depression's status as a devastating disease and suggest pathways toward resilience. Thought-provoking and enlightening,...
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Against Depression

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In his landmark bestseller Listening to Prozac, Peter Kramer revolutionized the way we think about antidepressants and the culture in which they are so widely used. Now Kramer offers a frank and unflinching look at the condition those medications treat: depression. Definitively refuting our notions of "heroic melancholy," he walks readers through groundbreaking new research—studies that confirm depression's status as a devastating disease and suggest pathways toward resilience. Thought-provoking and enlightening, Against Depression provides a bold revision of our understanding of mood disorder and promises hope to the millions who suffer from it.

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Editorial Reviews

From Barnes & Noble
Author Peter Kramer wants to give depression a bad name. The author of Listening to Prozac thinks that our culture has suffered from a centuries-long romance with sadness. Refuting claims that depression is a source of soulfulness and creativity, he identifies it as a debilitating disease that plagues millions of Americans. More important, he describes the latest scientific findings about depression and explains their implications for treating this grim malady.
Natalie Angier
Kramer presents a sustained case that depression, far from enhancing cognitive or emotional powers, essentially pokes holes in the brain, killing neurons and causing key regions of the prefrontal cortex -- the advanced part of the brain, located just behind the forehead -- to shrink measurably in size. He lucidly explains a wealth of recent research on the disease, citing work in genetics, biochemistry, brain imaging, the biology of stress, studies of identical twins. He compares the brain damage from depression with that caused by strokes. As a result of diminished blood flow to the brain, he says, many elderly stroke patients suffer crippling depressions.
David Brown
In his new book, Peter D. Kramer examines depression with a cool, intelligent and sympathetic eye. The author of the wildly popular Listening to Prozac , he is a practicing psychiatrist who sees depression and its human cost nearly every working day. He asks two interesting questions: If we could eradicate depression, would we? And if we did, would we lose anything of value?
— The Washingon Post
Publishers Weekly
What is depression really, and how does society define it? Kramer, a famed psychiatrist and author of the 1993 bestseller Listening to Prozac, says he has written "an insistent argument that depression is a disease, one we would do well to oppose wholeheartedly." In making his argument, Kramer examines the cultural roots of notions about depression and underscores the gap between what we know scientifically and what we feel about the illness. Kramer traces depression from Hippocrates through the Renaissance and Romantic "cult of melancholy" to advances in medicine, psychiatry and psychotherapy, and at last to the disease we now know it to be. Kramer's curiosity drives the book forward as he ponders why we value artwork and literature built on despair: "certain of our aesthetic and intellectual preferences have been set by those who suffer... deeply." The book maintains the perfect balance between science and human interest, as the author details both psychiatric studies and personal experience. A comparison of the biochemical workings of depression with the physical and observable symptoms serves as an intellectual trip for readers and provides a thorough exploration of what Kramer dubs "the most devastating disease known to humankind." The book is rich with questions that engage the reader in an active dialogue: Why is society captive to depression's charm? And will this infatuation change with the emergence of more evidence regarding depression's severely disabling effects? Kramer leaves off with these questions to ponder. Resolute but not preachy, this book is an important addition to the growing public health campaign against depression. As for how we should definedepression-perhaps it's best understood by its opposite: "A resilient mind, sustained by a resilient brain and body."
Copyright 2005 Reed Business Information.
Library Journal
In his best-selling Listening to Prozac, psychiatrist Kramer (Brown Univ.) explored the social implications of psychotropic personality change; he did not address the actual effects of these drugs on the severely depressed, yet he was constantly asked, "What if van Gogh (or, in Denmark, Kierkegaard) had been given antidepressants?"-the suggestion being that depression, or the depressive personality, is important to the production of works of genius. This led to the present book, which examines the question, "If we could eradicate depression so that no human being ever suffered it again, would we?" His answer is a resounding yes; depression is a major cause of distress with no redeeming value. In the process, he argues that the idea of "heroic melancholy" is simply a way our culture has developed to cope with a disorder that we can't cure-analogous to the way that tuberculars were once thought to be especially sensitive and creative. Along the way, Kramer offers an excellent summary of current biochemical theories of depression. Highly recommended for both public and academic libraries. —Ann Hughes, Neill P.L., Pullman, WA
Copyright 2005 Reed Business Information.
Kirkus Reviews
A heartfelt argument that depression is not, as many would have it, a source of heroic melancholy and artistic genius, but, rather, a pathological condition that should, if possible, be eradicated. When Kramer (Clinical Psychiatry/Brown Univ.) made public appearances after publication of his best-selling Listening to Prozac (1993), audiences persistently challenged him with questions like, "What if Prozac had been available in van Gogh's time?" The assumption that suffering from mental illness is a prerequisite to genius and that humanity would be the poorer if depression were conquered is anathema to Kramer. Instead, he asserts, it is "the most devastating disease known to humankind," and to back up his claim he cites some astonishing statistics: $40 billion in lost productivity in the United States, for example, or 3 percent of GDP. In a wide-ranging essay that draws on his own life and on his years of treating patients, he explores the gap between common perceptions of depression and the scientific understanding of it. In the first of three parts here, "What It Is to Us," he looks at the charm of depression and its erotic power, at the way people are drawn to such precursors of depression as moodiness, passivity and vulnerability. In "What It Is," he reviews research in biological psychiatry and neuroscience that links depression to frank abnormalities in the nervous system, including problems in stress responses, repair of cells in critical brain regions, and small or malfunctioning hippocampus glands. Finally, in "What It Will Be," Kramer envisions a world without depression and lists benefits of its eradication. Without depression to fear, he says, we would be free to be quirky andneurotic, to take risks more openly and to love more generously-and we'd still have art and artists. While not predicting that depression will be eliminated anytime soon, Kramer brings hope to those afflicted by it. A clear, valuable exposition of the progress researchers are making in understanding an all-too-common disease. Author tour
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Product Details

  • ISBN-13: 9781101201145
  • Publisher: Penguin Group (USA)
  • Publication date: 7/25/2006
  • Sold by: Penguin Group
  • Format: eBook
  • Pages: 368
  • Sales rank: 411,012
  • File size: 898 KB

Meet the Author

Peter D. Kramer, M.D., recently named host of the national, weekly public radio series, The Infinite Mind, is "possibly the best-known psychiatrist in America," as The New York Times put it. Peter Kramer received his M.D. from Harvard and is the best-selling author of Listening to Prozac, Should You Leave?, Spectacular Happiness, and Moments of Engagement. His latest book, Against Depression, will be published in May 2005.

In 2004, two programs of The Infinite Mind hosted by Kramer won top media awards: a Gracie Allen Award from the American Women in Radio and Television for an examination of "Domestic Violence" and a National Mental Health Association Media Award for “Between Two Worlds: Mental Health for Immigrants. Kramer has written for The New York Times Magazine and The New York Times Book Review, The Washington Post Book Review, The Washington Post, the (London) Times Literary Supplement and U.S. News&World Report, among other publications. He lives in Providence, Rhode Island, where he is Clinical Professor of Psychiatry and Human Behavior at Brown University, and has a private practice.

Visit Dr. Peter D. Kramer on the web: 

The Infinite Mind:

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Table of Contents


What It Is to Us
1. The Final Memoir
2. Return
3. What If
4. Ambivalence
5. Altogether
6. Charm
7. More Charm
8. Eros
9. Obvious Confusion: Three Vignettes

What It Is
10. Altogether Again
11. Getting There
12. Magnitude
13. Extent
14. Convergence
15. Resilience
16. Here and Now

What It Will Be
17. The End of Melancholy
18. Art
19. The Natural
20. Alienation
21. After Depression

Notes Index

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Customer Reviews

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Sort by: Showing 1 – 9 of 5 Customer Reviews
  • Anonymous

    Posted November 22, 2007

    A reviewer

    I'm a big fan of Peter Kramer's books, especially Listening to Prozac, which is a psychopharmacological classic. Against Depression does not disappoint either, and in it he dispels the modern notion that depression should be held in esteem and even romanticized. He instead sees depression as simply an ugly, biological disease of the brain, that can also have negative effects on the rest of the body. He cites evidence that depression can be associated with damage to the brain, which is a frightening possibility. On the other hand, it should be noted that within the last decade or so it has been shown that the adult human brain can generate new neurons, so perhaps the brain can heal itself from potential damage due to depression. A mild criticism: perhaps Dr. Kramer should draw a distinction between someone who's a bit melancholic and wistful--where these two traits may be viewed as appealing by some--and someone with overt major depression, including sleep disturbance and other highly unpleasant symptoms. The former person may not have anything truly 'wrong' with his brain, whereas the latter probably does. Overall, a very well written book, with a philosophical bent, that should appeal to anyone interested in depression.

    5 out of 5 people found this review helpful.

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