Ageing Vulnerability: Causes and Interventions - No. 235 / Edition 1

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Aging at individual and population levels presents one of the greatest challenges to humankind as we begin the 21st century. Throughout the world, older adults are the fasts growing population group. Aging is associated with an increased risk for development of chronic diseases that contribute to morbidity and mortality.
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Product Details

  • ISBN-13: 9780471494386
  • Publisher: Wiley
  • Publication date: 3/28/2001
  • Series: Novartis Foundation Symposia Series , #204
  • Edition number: 1
  • Pages: 292
  • Product dimensions: 6.22 (w) x 9.35 (h) x 0.73 (d)

Meet the Author

Iminosugars may be regarded as glycomimetics, alkaloids, natural products or as potential drugs. This book should therefore interest academic and industrial researchers in various areas such as organic synthesis, carbohydrate chemistry, medicinal chemistry, biochemistry, biotechnology, biology and medical sciences.
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Table of Contents

Introduction 1
The priority of basic research on ageing vulnerability in a comprehensive research agenda on ageing for the 21st century 4
Do alterations in glutathione and iron levels contribute to pathology associated with Parkinson's disease? 11
Specific metal-catalysed protein oxidation reactions in chronic degenerative disorders of ageing: focus on Alzheimer's disease and age-related cataracts 26
Multiple substrates of late-onset dementia: implications for brain protection 49
Ageing of murine small intestinal stem cells 66
Haematopoietic stem cell ageing 85
Identification of genes involved in cell senescence and immortalization: potential implications for tissue ageing 105
Ageing and cancer: the telomere and telomerase connection 116
Ageing and the immune system 130
Mechanisms of age-related bone loss 150
The old heart: operating on the edge 172
Pharmaceutical intervention of advanced glycation endproducts 202
The anti-ageing action of dietary restriction 221
Mitochondrial DNA mutations in disease and ageing 234
A mitochondrial paradigm for degenerative diseases and ageing 247
Index of contributors 273
Subject index 275
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