Aging and the Heart: A Post-Genomic View / Edition 1

by Josï Marïn-Garcïa, M.J. Goldenthal, G.W. Moe

Overview

In this book, the genetic and molecular basis of cardiovascular aging is examined in detail and a comprehensive assessment given of the bioenergetics changes occurring in human and animal models of cardiac aging. Both current diagnostic and future therapeutic modalities are presented, giving this book a dual-pronged approach. Cardiac aging, like aging in general, is a complex process involving numerous cellular and molecular changes. This book sheds new light on the phenomenon.

Product Details

ISBN-13:	9780387740713
Publisher:	Springer US
Publication date:	12/19/2007
Edition description:	2008
Pages:	568
Product dimensions:	7.01(w) x 10.00(h) x 0.05(d)
Age Range:	3 Months

Table of Contents

Preface.- Section I. Introduction to A Post-Genomic View of Aging and the Aging Heart: Post-Genomic View of Aging: Definitions, Theories and Observations.- Overview of Cardiovascular Aging.- Section II. Methodologies, Cardiac Phenotypes And Adaptation: Molecular and Cellular Methodologies.- Molecular And Cellular Phenotypes of Cardiac Aging.- Section III. Aging of the Cardiovasculature and Related Systems: Aging of the Vasculature.- Aging of Cardiovascular-Related Systems.- Section IV. Cardiovascular Diseases in Aging: Cardiomyopathy and Heart Failure in Aging.- Atherosclerosis, Hypertension and Aging.- Metabolic Syndrome, Diabetes and Cardiometabolic Risks in Aging.- Gender and Cardiovascular Aging.- Cardiac Dysrhythmias and Channelopathies in Aging.- Section V. Genetics: Genetics of Life Span: Lessons from Model Organisms.- Profiling the Aging Cardiovascular System: Transcriptional, Proteomic, SNP, Gene Mapping and Epigenetics Analysis.- Section VI. Therapies: Translational Research: Pharmacogenomics, Gene and Cell-Based Therapy in the Aging Cardiovascular System.- Nutrition and Exercise in Cardiovascular Aging: Metabolic and Pharmacological Interventions.- Section VII. The Future of Aging Research: Aging and the Frontier ahead.- Glossary.- Index.

Editorial Reviews

Reviewer: Arindam Banerjee, M.D.(Ochsner Clinic Foundation)
Description: This is a comprehensive review of basic science research in the field of aging in the context of clinically relevant cardiovascular disorders.
Purpose: The purpose is to provide an understanding of the biochemical, molecular, and genetic aspects of cardiovascular aging.
Audience: It is intended for both basic scientists and clinicians with at least some experience in biochemistry, molecular and cell biology, and genetics who are interested in cardiovascular aging.
Features: The book covers the mechanisms of aging in the context of many clinically relevant cardiovascular disorders, including hypertension, atherosclerosis and myocardial infarction, heart failure, and arrhythmias. It also offers an introduction to gene and cell-based therapies as well as the direction of future research. The best features of this book are its comprehensiveness, with its numerous sources of research, and its integration of basic science research into relevant clinical topics. A major shortcoming is the chapter organization, which makes it somewhat difficult to navigate the vast amount of information.
Assessment: This is an excellent, comprehensive review of the mechanisms of cardiovascular aging.

Doody's Review Service

From the reviews:

"A comprehensive and authoritative book about cardiac senescence in the postgenomic period. … The book is extensively referenced and thoroughly researched. The bibliographies provided after each chapter are exhaustive, and the end of the book includes an ample glossary section defining the plethora of acronyms used throughout." (M. Saleem Seyal, JAMA, Vol. 300 (9), 2008)

“This is a comprehensive review of basic science research in the field of aging in the context of clinically relevant cardiovascular disorders. … It is intended for both basic scientists and clinicians with … some experience in biochemistry, molecular and cell biology, and genetics who are interested in cardiovascular aging. … The best features of this book are its comprehensiveness, with its numerous sources of research, and its integration of basic science research into relevant clinical topics.” (Arindam Banerjee, Doody’s Review Service, January, 2010)

From the Publisher

Reviewer: Arindam Banerjee, M.D.(Ochsner Clinic Foundation)
Description: This is a comprehensive review of basic science research in the field of aging in the context of clinically relevant cardiovascular disorders.
Purpose: "The purpose is to provide an understanding of the biochemical, molecular, and genetic aspects of cardiovascular aging. "
Audience: It is intended for both basic scientists and clinicians with at least some experience in biochemistry, molecular and cell biology, and genetics who are interested in cardiovascular aging.
Features: The book covers the mechanisms of aging in the context of many clinically relevant cardiovascular disorders, including hypertension, atherosclerosis and myocardial infarction, heart failure, and arrhythmias. It also offers an introduction to gene and cell-based therapies as well as the direction of future research. The best features of this book are its comprehensiveness, with its numerous sources of research, and its integration of basic science research into relevant clinical topics. A major shortcoming is the chapter organization, which makes it somewhat difficult to navigate the vast amount of information.
Assessment: This is an excellent, comprehensive review of the mechanisms of cardiovascular aging.