AIDS: The Biological Basis, Third Edition / Edition 3

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The award-winning AIDS: The Biological Basis, now in its third edition, has been revised and updated to meet the needs of students, academics and AIDS professionals. While retaining the same successful pedagogical features that made it so effective in previous editions, Dr. Alcamo has added critical, up-to-date information on AIDS and HIV, including: the physiology of the HIV-T cell relationship; the spread of AIDS throughout Africa and Asia; new insights into needle exchange programs; how the viral load has become a key diagnostic tool for tracking HIV infection; the use of zidovudine to control pediatric AIDS; work on the AIDS vaccine; and the use of HAART to control AIDS in adults.

Intro. to what is known about AIDS & HIV, epidemiology, preventing HIV transmission, testing, diagnosis, treatment.

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Editorial Reviews

Doody's Review Service
Reviewer: Marvin J. Bittner, MD, MSc, FACP, FIDSA, FSHEA (Creighton University Medical Center)
Description: Written for an audience with no more technical background than that of the daily newspaper reader, this work updates the 1996 edition in a student-friendly textbook that amounts to a sort of encyclopedia of AIDS.
Purpose: Education in the biological basis of AIDS is the author's goal — and an important one. Advancing toward that goal, he provides clear explanations, engaging descriptions of the significance of research, and wide-ranging explanations of AIDS biology, from "What is a virus?" to "How does a DNA vaccine work?" Frustrating the effort are inaccuracy (Kaposi's sarcoma is said on p. 100 to be described in 1924, but Dr. Kaposi died in 1902) and outdated material (a common pneumonia in AIDS is described on p. 245 as caused by protozoan Pneumocystis carinii and treated preferably with pentamidine — rather than caused by the fungus Pneumocystis jiroveci and treated preferably with trimethoprim-sulfamethoxazole).
Audience: The author seeks an audience ranging from the term paper writer to the physician, and the book will be appropriate for just such a broad audience. Admittedly, the term paper writer may have limited interest in details of needlestick exposure management. Many physicians may know much of the fundamentals, yet learn from the author's lucid descriptions of research, such as the coin-flip strategy (p. 131) for eliciting sexual behavior histories. The author, who died before publication, was a university-level PhD professor of microbiology.
Features: Extensive coverage of AIDS includes history, cause, diagnosis, treatment, prevention, and ongoing research. Many features assist learning. Each chapter has an outline, a list of goals, sidebars with frequently asked questions, sidebars with explanations, numerous illustrations, a concluding summary, review questions (with answers), and references for further reading. Illustrations include patient photos, maps, graphs, and diagrams. The book concludes with an outline for a 10-session course, a pronunciation guide, and a glossary. This book treats AIDS with what has been described as "the signature Alcamo style, which includes a friendly tone, personal writing style, student-friendly organization, and real-world applications."
Assessment: Although outstanding for pedagogical technique, this book's value is impaired by inaccurate, outdated material. I hope that, as with Dr. Alcamo's microbiology text (Pommerville, Alcamo's Fundamentals of Microbiology, 7th Edition (Jones & Bartlett, 2004)), a colleague will update the content and retain the style.

3 Stars from Doody
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Product Details

  • ISBN-13: 9780763702380
  • Publisher: Jones & Bartlett Learning, LLC
  • Publication date: 4/23/2003
  • Edition description: Older Edition
  • Edition number: 3
  • Pages: 340
  • Product dimensions: 7.70 (w) x 9.66 (h) x 0.88 (d)

Table of Contents

1 The AIDS Epidemic 2
The Early Years 3
Origin of the AIDS Epidemic 13
The First Decades and Beyond 21
2 Viruses and HIV 30
Structure of Viruses and HIV 31
Replication of Viruses and HIV 36
The HIV Genome 48
Inhibiting Viruses 51
3 The Immune System and HIV 58
Development of the Immune System 60
Antigens 64
The Immune Process 65
HIV and the Immune System 71
4 Defining and Recognizing AIDS 84
The Case Definition 85
HIV Infection 86
AIDS-Related Complex 90
Acquired Immune Deficiency Syndrome 94
Pediatric AIDS 108
5 The Epidemiology of AIDS 114
AIDS and the Epidemiologist 115
The Spreading Epidemic 117
How AIDS Is Not Transmitted 142
AIDS in Schools and Colleges 144
6 Preventing HIV Transmission 152
Personal Protection 153
Protecting Health Care Workers 162
Protecting Public Safety Workers 172
AIDS Education in the Schools 177
7 HIV Testing and Diagnosis 184
HIV Antibody Tests 185
HIV Antigen (Viral Load) Tests 195
Implications of HIV Testing 202
8 Treating HIV Infection and AIDS 212
General Principles of AIDS Treatment 214
Reverse Transcriptase Inhibitors 220
Other Therapeutic Agents 230
Treating Opportunistic Diseases 245
Drug Development and Testing 247
Alternative Therapies 251
9 An AIDS Vaccine 260
General Vaccine Strategies 262
AIDS Vaccine Strategies 265
A Whole-Virus Vaccine 272
Problems in Vaccine Development 272
Lack of Animal Models 277
Vaccine Trials 279
10 AIDS in Perspective 288
AIDS and Society 289
Caring for the AIDS Patient 305
The Future of AIDS 307
App. A: Answers to Review Questions 316
App. B A Suggested Format for a 10-Session Course: The Biological Basis of AIDS 317
Pronunciation Guide 319
Glossary 321
Index 328
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